Flavin Containing Monooxygenase 3 蛋白 (FMO3)

Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. 再加上,我们可以发FMO3 抗体 (88)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
FMO3 2328 P31513
FMO3 14262 P97501
FMO3 84493 Q9EQ76
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
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FMO3 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

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Human Flavin Containing Monooxygenase 3 (FMO3) interaction partners

  1. Finally, understanding the binding mode of methimazole and indole could be advantageous for development of hFMO3 inhibitors, currently investigated as a possible treatment strategy for atherosclerosis

  2. Report developmental regulation of hepatic FMO3 expression.

  3. the involvement of flavin-containing monooxygenase-3 (FMO3) and cytochrome P450 enzymes (CYPs) in Busulphan metabolic pathway, is reported.

  4. FMO3 protein abundance is significantly associated with age, gender, and genotype

  5. FMO3 Variant is associated with chronic kidney disease.

  6. Study tested the genetic effects of three FMOs genes (FMO1, FMO3, and FMO6P) on nicotine dependence by performing targeted sequencing on 2,852 nicotine-dependent and nondependent smokers; identified significant association signals for gene FMO1 and FMO6P

  7. The two FMO3 mutants were in close linkage disequilibrium and might play an important role in the pharmacokinetics of sulindac in Chinese healthy male volunteers.

  8. mechanism of hFMO3 which could be valuable not only for screening of new chemical entities but more significantly for designing of novel inhibitors of this important Phase I drug metabolising enzyme.

  9. Olanzapine clearance was not affected by CYP2D6 or FMO3 genotypes or smoking behavior as a single factor under the present conditions because olanzapine clearance is mediated by multiple enzymes involved in two major and one minor pathways

  10. Oxidative stress-responsive transcription factor NRF2 is not indispensable for the human hepatic Flavin-containing monooxygenase-3 (FMO3) gene expression in HepG2 cells

  11. FMO3 gene polymorphism E158K is a significant predictor of predisposition to chronic heart disease in women.

  12. FMO3 is centrally involved in the pathogenesis of atherosclerosis by regulating cholesterol metabolism and insulin resistance. [Review]

  13. FMO3 expression is increased in obese/insulin resistant patients.

  14. These results suggest that genetic polymorphism in the human FMO3 gene may lead to changes of drug interactions for N- or S-oxygenations of xenobiotics and endogenous substances.

  15. Effect of two-linked mutations of the FMO3 gene on itopride metabolism in Chinese healthy volunteers

  16. Three polymorphisms were found in intronic regions of FMO3 in a child with trimethylaminuria and in her parents and a brother. The parents and brother showed no symptoms.

  17. Comparisons of genotype and phenotype reveal that severe trimethylaminuria is caused by loss of function mutations in FMO3

  18. results show that FMO3 E158K and POR A503V polymorphisms are minor sources of nicotine metabolism variation, insufficient to appreciably alter smoking.

  19. CYP3A4 and FMO3 are the major enzymes responsible for the metabolism of teneligliptin in humans.

  20. FMO3 (rs2266780) was in complete linkage disequilibrium with FMO6.

Cow (Bovine) Flavin Containing Monooxygenase 3 (FMO3) interaction partners

  1. Fishy off-flavor in cow's milk is caused by a nonsense mutation (R238X) in FMO3, found to be surprisingly common (q = 0.155) in the Swedish Red and White breed of dairy cattle.

Mouse (Murine) Flavin Containing Monooxygenase 3 (FMO3) interaction partners

  1. Diabetes induced the expression of both Fmo3 and ICAM expression and possible vascular impairment through enteric dysbiosis. Diabetes-induced Fmo3 and ICAM expression could be reversed by pJNK inhibition or by correcting enteric dysbiosis.

  2. The suppression of FMO3 metabolism related to reversible S-nitrosyl modifications of iNOS-derived NO in type 1 allergic mice.

  3. knockdown or genetic deletion of the TMAO-producing enzyme flavin-containing monooxygenase 3 (FMO3) confers protection against obesity in mice.

  4. FMO3 can contribute to the regulation of glucose metabolism in the liver by reducing lipid-induced endoplasmic reticulum stress and the expression of PEPCK, independently of insulin signal transduction.

  5. FMO3 is increased in obese/insulin resistant male mice and necessary for expression of FoxO1.

  6. Fmo3 expression and function plays a role in protecting the liver from acetaminophen-induced toxicity.

  7. a major role for FMO3 in modulating glucose and lipid homeostasis

  8. Report temporal changes in hepatic Fmo3 gene expression under different conditions all known to cause hepatic oxidative stress.

  9. Report selective modulation of hepatic cytochrome P450 and flavin monooxygenase 3 expression during citrobacter rodentium infection in SCID mice.

  10. The functional activity of Fmo3 was determined.

蛋白简介FMO3

蛋白简介

Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.

Gene names and symbols associated with FMO3

  • flavin containing monooxygenase 3 (FMO3)
  • flavin containing monooxygenase 3 (fmo3)
  • flavin containing monooxygenase 3 L homeolog (fmo3.L)
  • flavin containing monooxygenase 3 (Fmo3)
  • AW111792 蛋白
  • dJ127D3.1 蛋白
  • FM03 蛋白
  • FMOII 蛋白
  • MGC107820 蛋白
  • TMAU 蛋白

Protein level used designations for FMO3

dimethylaniline monooxygenase [N-oxide-forming] 3 , flavin containing monooxygenase 3 , FMO 3 , FMO II , FMO form 2 , dimethylaniline oxidase 3 , hepatic flavin-containing monooxygenase 3 , hepatic flavin-containing monooxygenase-3 , trimethylamine monooxygenase , flavin-containing monooxygenase 3 , FMO 1D1 , flavin-containing monooxygenase FMO3 , flavin-containing monooxygenase form 3

GENE ID SPECIES
100171678 Pongo abelii
548424 Xenopus (Silurana) tropicalis
447265 Xenopus laevis
2328 Homo sapiens
403603 Canis lupus familiaris
281167 Bos taurus
100009065 Oryctolagus cuniculus
14262 Mus musculus
84493 Rattus norvegicus
457505 Pan troglodytes
574244 Macaca mulatta
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