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Acts as a regulator of the antiangiogenic activity on endothelial cells. 再加上，我们可以发和数多这个蛋白质的别的产品。
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FILIP1L inhibits progression in colorectal cancer by inhibiting tumor cell proliferation and angiogenesis.
Studies have shown that FILIP1L expression is related with inhibition of metastases and chemoresistance of ovarian neoplasm, which is associated with downregulation of EMT through beta-catenin degradation. FILIP1L expression correlates with significantly improved overall survival.
these findings suggest that FILIP1L reduces beta-catenin levels, which may lead to the transcriptional downregulation of WNT target genes such as MMPs, resulting in inhibition of metastasis
down-regulation of FILIP1L associated with DNA methylation is related with the invasive phenotype in various cancers.
In addition, eight genes classified as 'second tier' hits in the original study (PAX7, THADA, COL8A1/FILIP1L, DCAF4L2, GADD45G, NTN1, RBFOX3 and FOXE1) showed evidence of linkage and association in this replication sample.
these findings suggest that downregulation of FILIP1L associated with DNA methylation is related with the invasive phenotype in ovarian cancer and that modulation of FILIP1L expression has the potential to be a target for ovarian cancer therapy.
a novel function for FILIP-1L and a pathway for Hsf1 degradation through the ubiquitin-proteasome system.
GPBP directs myofibril formation through interaction with intracellular downstream effector 130-kDa GPBP-interacting protein
DOC1 might play a role in mediating some of the effects of EMAP-II on endothelial cells
Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor- associated vasculature.
130 kDa GPBP-interacting protein
, 90 kDa GPBP-interacting protein
, GPBP-interacting protein 90
, GPBP-interacting protein of 130 kDa
, downregulated in ovarian cancer 1 81 kDa isoform
, filamin A-interacting protein 1-like
, protein down-regulated in ovarian cancer 1
, downregulated in ovarian cancer 1-like
, protein down-regulated in ovarian cancer 1 homolog
, filamin A interacting protein 1-like