anti-Fermitin Family Member 1 (FERMT1) 抗体

FERMT1 encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. 再加上,我们可以发FERMT1 试剂盒 (7)FERMT1 蛋白 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
FERMT1 55612 Q9BQL6
FERMT1 241639 P59113
FERMT1 296179  
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Showing 10 out of 54 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-FERMT1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Human heart 100 μL Log in to see 2至3个工作日
$289.00
详细
Cow 非结合性 WB 100 μL Log in to see 2至3个工作日
$289.00
详细
Cow 非结合性 IHC, IHC (p), WB Human Placenta (formalin-fixed, paraffin-embedded) stained with FERMT1 antibody ABIN364270 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-FERMT1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Log in to see 11至14个工作日
$727.83
详细
非结合性 WB FERMT1 Antibody (Center) (ABIN652858) western blot analysis in Hela,HepG2 cell line lysates (35 µg/lane).This demonstrates the FERMT1 antibody detected the FERMT1 protein (arrow). Western blot analysis of FERMT1 Antibody (Center) (ABIN652858) in mouse stomach tissue lysates (35 µg/lane). FERMT1 (arrow) was detected using the purified polyclonal antibody 400 μL Log in to see 10至11个工作日
$385.00
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Cow 非结合性 WB 50 μg Log in to see 11至14个工作日
$551.83
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非结合性 WB Detection of URP1 in 20 ug of human lung adenocarcinoma cell line NCI-H322 lysate using ABIN151958. 0.1 mg Log in to see 7至9个工作日
$347.48
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非结合性 WB Western blot analysis in Hela,HepG2 cell line lysates (35ug/lane). Western blot analysis of FERMT1 Antibody in mouse stomach tissue lysates (35ug/lane). 400 μL Log in to see 2至3个工作日
$515.63
详细
非结合性 IHC, IHC (p), WB Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-FERMT1 / Kindlin antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100. 200 μL Log in to see 11至14个工作日
$484.00
详细
非结合性 IP, WB Immunoprecipitation of FERMT1 transfected lysate using anti-FERMT1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with FERMT1 purified MaxPab mouse polyclonal antibody (B01P) . Western Blot analysis of FERMT1 expression in transfected 293T cell line by FERMT1 MaxPab polyclonal antibody.Lane 1: FERMT1 transfected lysate(77.40 KDa).Lane 2: Non-transfected lysate. 100 μL Log in to see 11至12个工作日
$425.71
详细
非结合性 ELISA, WB 50 μg Log in to see 2至3个工作日
$446.88
详细

更多抗FERMT1的相互作用对抗体

Human Fermitin Family Member 1 (FERMT1) interaction partners

  1. Kindlin-1 is mainly expressed in the cytoplasm of normal esophageal squamous epithelium and Esophageal cancer (EC) cells. Kindlin-1 expression is positively correlated with tumor cell differentiation and is higher in stage I tumors. Kindlin-1 expression is higher in non-smoker patients than in smoker patients, and in patients with a family history of EC.

  2. Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin.

  3. we demonstrated that Kindlin-1 promotes CRC progression by recruiting SARA and Smad3 to TbetaRI and thereby activates TGF-beta/Smad3 signaling. Thus, Kindlin-1 is a novel regulator of TGF-beta/Smad3 signaling and may also be a potential target for CRC therapeutics.

  4. Sequence analysis of KIND1 exons in patient 1 revealed a commonly reported homozygous nonsense mutation in exon 6 (c.811C>T;p.R271X). Both Patients 2 and 3 had novel homozygous single nucleotide deletions

  5. KS patients' periodontal disease activity could be taken under control with regular follow-up.

  6. these data define a novel role for Kin1 in microtubule acetylation and stability

  7. keratinocytes derived from KS patients are unable to undergo electrotaxis, and this defect is restored by overexpression of wild-type kindlin-1 but not a W612A mutation that prevents kindlin-integrin binding.

  8. FERMT1 activates the beta-catenin transcriptional activity to promote EMT in CC metastasis.

  9. KIND1 is important not only for keratinocyte proliferation but also for the suppression of UV-induced inflammation and DNA damage.

  10. We show a direct relationship between kindlin-1 abundance and UV-B induced apoptosis in keratinocytes, whereas kindlin-2 overexpression has no compensatory effect.

  11. These results indicate that Kindlin-1 is essential in EGF-induced re-epithelialization in skin wound healing and provide additional rationale for the clinical application of EGF in the treatment of acute wounds.

  12. KS is caused by mutations in the FERMT1 gene. Including the present, more than 60 mutations in FERMT1 have been identified since 2003. In spite of the expanding FERMT1 mutation database, there seems to be a lack of a clear genotype-phenotype correlation in KS

  13. A nonsense mutation in Exon 5 of KIND1 Gene in an Iranian Family may lead to incomplete and non-functional protein products and is pathogenic and has meaningful implications for the diagnosis of patients with Kindler syndrome.

  14. we show that a certain number of KS patients may harbor FERMT1 transcriptional regulatory mutations which are not routinely detected.

  15. Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm, whereas Kindlin-2 is mainly expressed in mesoderm-derived tissues. Likewise, Kindlin-1 was also found highly expressed in endoderm/ectoderm-derived tissues in embryos.

  16. FERMT1 mutation causing Kindler syndrome.

  17. our data suggest that Kindlin-1 could play an important role in hepatocellular carcinoma and might serve as a promising prognostic marker and potential target for hepatocellular carcinoma therapy.

  18. A spectrum of FERMT1 mutations in 13 Iranian families with a diagnosis of Kindler syndrome have been ascertained.

  19. We identified a novel mutation in FERMT1. These data are in agreement with the fact that the majority of KS-causing mutations in FERMT1 lead to premature termination of translation and to loss of kindlin-1 function in Kindler sysndrome

  20. C-terminal LIM domains of migfilin dictate its focal adhesion localization, and these domains mediate an interaction with kindlin in vitro and in cells, demonstrating that kindlin is important for normal migfilin dynamics.

Mouse (Murine) Fermitin Family Member 1 (FERMT1) interaction partners

  1. Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin.

  2. loss of Kindlin-1 leads to an imbalance in the cellular oxidative state, which renders Kindlin-1 deficient cells more prone to the effects of reactive oxygen species generated in response to oxidative stress

  3. these data define a novel role for Kin1 in microtubule acetylation and stability

  4. These results indicate that Kindlin-1 is essential in EGF-induced re-epithelialization in skin wound healing and provide additional rationale for the clinical application of EGF in the treatment of acute wounds.

  5. By modulating its affinity with kindlin, beta3 integrin may be able to locate near the cell edge where it can control beta1 integrin activation and clustering.

  6. Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm. Kindlin-1 was also found highly expressed in endoderm/ectoderm-derived tissues in embryos.

  7. Kindlin-1 controls keratinocyte adhesion through beta1-class integrins and proliferation and differentiation of cutaneous epithelial stem cells via TGF-beta activation and Wnt-beta-catenin signal inhibition.

  8. Kindlin-1 and Kindlin-2 have opposite roles in lung cancers

  9. The genomic organization, gene expression and subcellular localization of murine Kindlins-1 to -3, is described.

  10. Kindlin-1 in mice gives rise to skin atrophy and an intestinal epithelial dysfunction with similarities to human ulcerative colitis.

  11. Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects

Xenopus laevis Fermitin Family Member 1 (FERMT1) interaction partners

  1. Kindlin1 knockdown resulted in developmental delays, gross malformations of the gut and eventual lethality by tadpole stages.

Zebrafish Fermitin Family Member 1 (FERMT1) interaction partners

  1. The rof/kindlin-1 mutant zebrafish provides a unique model system to study epidermal adhesion mechanisms in vivo.

FERMT1 抗原简介

蛋白简介

This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome.

Gene names and symbols associated with FERMT1

  • fermitin family member 1 (FERMT1) 抗体
  • fermitin family member 1 (Fermt1) 抗体
  • fermitin family member 1 S homeolog (fermt1.S) 抗体
  • fermitin family member 1 (fermt1) 抗体
  • fermitin family homolog 1 (LOC100548276) 抗体
  • 5830467P10Rik 抗体
  • C20orf42 抗体
  • DTGCU2 抗体
  • KIND1 抗体
  • Kindlin-1 抗体
  • RGD1306816 抗体
  • si:ch73-22c10.1 抗体
  • UNC112A 抗体
  • URP1 抗体
  • wu:fc32b07 抗体

Protein level used designations for FERMT1

UNC112 related protein 1 , fermitin family homolog 1 , kindlerin , kindlin 1 , kindlin syndrome protein , unc-112-related protein 1 , UNC-112 related protein 1 , fermitin family member 1 , fermitin family homolog 1-like , fc32b07

GENE ID SPECIES
55612 Homo sapiens
241639 Mus musculus
296179 Rattus norvegicus
379119 Xenopus laevis
458088 Pan troglodytes
485775 Canis lupus familiaris
524427 Bos taurus
718297 Macaca mulatta
100407542 Callithrix jacchus
416727 Gallus gallus
100332544 Danio rerio
100466357 Ailuropoda melanoleuca
100492800 Xenopus (Silurana) tropicalis
100548276 Meleagris gallopavo
100051761 Equus caballus
100157961 Sus scrofa
100732971 Cavia porcellus
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