Use your antibodies-online credentials, if available.
FERMT1 encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. 再加上，我们可以发FERMT1 试剂盒 (7) 和 FERMT1 蛋白 (5)和数多这个蛋白质的别的产品。
Showing 10 out of 53 products:
Kindlin-1 is mainly expressed in the cytoplasm of normal esophageal squamous epithelium and Esophageal cancer (EC) cells. Kindlin-1 expression is positively correlated with tumor cell differentiation and is higher in stage I tumors. Kindlin-1 expression is higher in non-smoker patients than in smoker patients, and in patients with a family history of EC.
Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin (显示 PXN 抗体).
we demonstrated that Kindlin-1 promotes CRC (显示 CALR 抗体) progression by recruiting SARA (显示 ZFYVE9 抗体) and Smad3 (显示 SMAD3 抗体) to TbetaRI (显示 TGFBR1 抗体) and thereby activates TGF-beta (显示 TGFB1 抗体)/Smad3 (显示 SMAD3 抗体) signaling. Thus, Kindlin-1 is a novel regulator of TGF-beta (显示 TGFB1 抗体)/Smad3 (显示 SMAD3 抗体) signaling and may also be a potential target for CRC (显示 CALR 抗体) therapeutics.
Sequence analysis of KIND1 exons in patient 1 revealed a commonly reported homozygous nonsense mutation in exon 6 (c.811C>T;p.R271X). Both Patients 2 and 3 had novel homozygous single nucleotide deletions
these data define a novel role for Kin1 in microtubule acetylation and stability
keratinocytes derived from KS patients are unable to undergo electrotaxis, and this defect is restored by overexpression of wild-type kindlin-1 but not a W612A mutation that prevents kindlin-integrin binding.
FERMT1 activates the beta-catenin (显示 CTNNB1 抗体) transcriptional activity to promote EMT (显示 ITK 抗体) in CC metastasis.
KIND1 is important not only for keratinocyte proliferation but also for the suppression of UV-induced inflammation and DNA damage.
We show a direct relationship between kindlin-1 abundance and UV-B induced apoptosis in keratinocytes, whereas kindlin-2 (显示 FERMT2 抗体) overexpression has no compensatory effect.
These results indicate that Kindlin-1 is essential in EGF (显示 EGF 抗体)-induced re-epithelialization in skin wound healing and provide additional rationale for the clinical application of EGF (显示 EGF 抗体) in the treatment of acute wounds.
loss of Kindlin-1 leads to an imbalance in the cellular oxidative state, which renders Kindlin-1 deficient cells more prone to the effects of reactive oxygen species generated in response to oxidative stress
By modulating its affinity with kindlin, beta3 integrin (显示 ITGB3 抗体) may be able to locate near the cell edge where it can control beta1 integrin activation and clustering.
Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm. Kindlin-1 was also found highly expressed in endoderm/ectoderm-derived tissues in embryos.
Kindlin-1 controls keratinocyte adhesion through beta1-class integrins and proliferation and differentiation of cutaneous epithelial stem cells via TGF-beta (显示 TGFB1 抗体) activation and Wnt (显示 WNT2 抗体)-beta-catenin (显示 CTNNB1 抗体) signal inhibition.
Kindlin-1 and Kindlin-2 (显示 FERMT2 抗体) have opposite roles in lung cancers
Kindlin-1 in mice gives rise to skin atrophy and an intestinal epithelial dysfunction with similarities to human ulcerative colitis.
Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects
Kindlin1 knockdown resulted in developmental delays, gross malformations of the gut (显示 GUSB 抗体) and eventual lethality by tadpole stages.
The rof/kindlin-1 mutant zebrafish provides a unique model system to study epidermal adhesion mechanisms in vivo.
This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome.
UNC112 related protein 1
, fermitin family homolog 1
, kindlin 1
, kindlin syndrome protein
, unc-112-related protein 1
, UNC-112 related protein 1
, fermitin family member 1
, fermitin family homolog 1-like