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FTO is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of FTO is not known.
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FTO rs9939609 is associated with obesity risk and LTL in this study, where this association is only observed at higher, but not lower, FTO methylation levels of participants. Our data suggest association of multiple factors, including FTO methylation level, may be involved in one of several mechanisms underlying the commonly reported obesity risk of this FTO polymorphism.
This study indicates that FTO expression may have an important role in promoting the occurrence of gastric cancer (GC), and it may be an vital molecular marker in the diagnosis and prognosis of GC patients
Mediterranean Diet adherence can be useful for prevention or treatment of obesity phenotypes in subjects with FTO risk alleles.
FTO increased the lipid accumulation in hepatocytes by increasing nuclear translocation of SREBP1c (显示 SREBF1 ELISA试剂盒) and SREBP1c (显示 SREBF1 ELISA试剂盒) maturation, thus improving the transcriptional activity of lipid droplet-associated protein (显示 PLIN1 ELISA试剂盒) CIDEC (显示 CIDEC ELISA试剂盒).
Two FTO variants, found in 14 affected individuals from three families, were also associated with leanness in these patients with Delayed Puberty. One variant (p.Leu44Val) demonstrated altered demethylation activity of the mutant protein in vitro. Mutations in genes implicated in body mass and timing of puberty in the general population may contribute to the pathogenesis of self-limited delayed puberty.
The aggregation analysis revealed a higher correlation between siblings than between parent-offspring pairs representing the role of genetic factors in metabolic syndrome (MetS). In addition, the conditional logistic model with covariates showed that the linkage results between HDL_C and three markers, FTO (rs1558902 and rs7202116) and CETP (显示 CETP ELISA试剂盒)(rs1864163) were significant.
genetic association studies in population of adolescents in the United States: Data suggest that an SNP in FTO (rs9939609) is associated with adolescent overweight/obesity and obesogenic appetitive traits (decreased satiety responsiveness and increased food responsiveness) in the population studied.
This meta-analysis provides additional support for a significant interaction between FTO, depression and BMI, indicating that depression increases the effect of FTO on BMI.
children at risk for obesity possessing the obesity risk polymorphism (FTO rs9939609) exhibited stronger responses to food commercials in the nucleus accumbens (NAcc) than children not at risk. Similarly, children at a higher genetic risk for obesity possessing the obesity risk polymorphism (FTO rs9939609) demonstrated larger NAcc volumes.
Variations within FTO may be predictors of fatty liver disease in HIV-infected patients independently of metabolic factors.
Mutations in genes implicated in body mass and timing of puberty in the general population may contribute to the pathogenesis of self-limited delayed puberty. Fto+/- mice displayed a significantly delayed timing of pubertal onset as well.
FTO demethylase (显示 MBD2 ELISA试剂盒) activity is essential for normal bone development and mineralization, a previously unreported FTO function.
FTO is critically involved in insulin (显示 INS ELISA试剂盒) defects-related Alzheimer's disease.
This is the first study revealing the presence of a parallel increase in expressions of FTO and HNRNPK (显示 HNRNPK ELISA试剂盒) proteins. This increase may codictate the metabolic changes occurring in the cell and may attribute a significance to HNRNPK (显示 HNRNPK ELISA试剂盒) in FTO-associated transformations.
Contextual fear conditioning decreased FTO levels in neurons from the hippocampus.
The involvement of mTOR (显示 FRAP1 ELISA试剂盒)-PGC-1alpha (显示 PPARGC1A ELISA试剂盒) pathway in the connection between FTO and muscle differentiation is displayed.
In vivo experiments revealed that Fto(-/-) and Fto(+/-) mice were more susceptible to thiopurine-induced myelosuppression than wild-type mice.
propose that PKCbeta acts to suppress the degradation of FTO protein and reveals the associated role of PKCbeta and FTO in adipogenesis, suggesting a new pathway that affects the development of obesity and metabolic diseases
the results of this study indicate that the effects of FTO-associated SNPs on energy homeostasis are due in part to the effects of these genetic variations on hypothalamic FTO, RPGRIP1L (显示 RPGRIP1L ELISA试剂盒), and possibly other genes.
FTO may have a deleterious role in hepatic cells during lipotoxic conditions, and up-regulation of FTO may contribute to the increased liver damage in non-alcoholic steatohepatitis
Studied role of FTO alpha-ketoglutarate dependent dioxygenase (FTO) in adipogenesis of intramuscular adipocytes.
In this study, the authors characterise the nucleotide variability and haplotype diversity of the porcine fat mass and obesity-associated (FTO) gene in breeds having different predispositions to fat deposition traits.
In pig, the FTO gene influences back fat depth in the commercial populations.
This study will provide clues for obtaining a better understanding of the porcine FTO gene function.
The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits in the Italian Duroc pigs (P < 0.01) and in the commercial pigs.
The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs.
34 FTO polymorphisms revealed significant association of FTO variants with lean meat percentage in Simmental and Brown cattle breeds.
association signals not only provided evidence for at least two causative mutations in the FTO locus with a functional effect on milk but also milk protein (显示 CSN2 ELISA试剂盒) yield
Haplotype frequencies and linkage disequilibrium (LD) coefficients of FTO single nucleotide polymorphisms in three Chinese indigenous cattle breeds were analyzed.
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.
alpha-ketoglutarate-dependent dioxygenase FTO
, fat mass and obesity-associated protein
, protein fto
, protein fatso
, fat mass and obesity associated protein
, Protein fatso