Fasciculation and Elongation Protein zeta 1 (Zygin I) 蛋白 (FEZ1)

FEZ1 is an ortholog of the C. 再加上,我们可以发FEZ1 抗体 (65)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
FEZ1 9638 Q99689
FEZ1 235180 Q8K0X8
FEZ1 81730 P97577
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FEZ1 蛋白 by Origin and Source

Origin 在表达 标记
Human ,
,
Mouse (Murine)

Rat (Rattus)

更多Fasciculation and Elongation Protein zeta 1 (Zygin I) (FEZ1)互动伙伴

Human Fasciculation and Elongation Protein zeta 1 (Zygin I) (FEZ1) interaction partners

  1. FEZ1 promotes HIV-1 infection in non-neuronal cells via direct binding to the capsid and kinesin-1 to move the virus into the cell nucleus.

  2. SCOC forms a stable homogeneous complex with the coiled coil domain of FEZ1. SCOC dimerization and the SCOC surface residue R117 are important for this interaction.

  3. Studies indicate that FEZ1 (fasciculation and elongation protein zeta 1), SCOCO (short coiled-coil protein) and kinesins (kinesin heavy chain) are involved in biological transport process.

  4. Short Disrupted-in-Schizophrenia (DISC)1 splice variants show reduced or no binding to NDEL1 and phosphodiesterase (PDE)4B proteins but fully interact with FEZ1 and GSK3beta.

  5. FEZ1 operates as a kinesin adaptor for the transport of Stx, with cargo loading and unloading being regulated by protein kinases.

  6. The data of this study suggested that FEZ1 may play important roles in human astrocytes, and that mood stabilizers might exert their cytoprotective and mood-stabilizing effects by inducing FEZ1 expression in astrocytes.

  7. Genetic association analysis of two independent cohorts of schizophrenia patients and healthy controls reveals an epistatic interaction between FEZ1 and disrupted in schizophrenia (DISC)1.

  8. FEZ2 interacted with 59 proteins and that of these only 40 interacted with FEZ1.

  9. Demonstrated the formation of an intermolecular disulfide bond through FEZ1 Cys-133, which appears to be essential for dimerization.

  10. Studies indicate that suppression of FEZ1 expression in cultured embryonic neurons causes deficiency of neuronal differentiation.

  11. Data report that NEK1 and CLASP2 colocalize with FEZ1 in a perinuclear region in mammalian cells, and observed that coiled-coil interactions occur between FEZ1/CLASP2 and FEZ1/NEK1 in vitro.

  12. interacts with NBR1 protein

  13. FEZ1 is an interacting partner of DISC1. The interaction of DISC1 and FEZ1 is associated with direct FEZ1 binding to F-actin.

  14. E4B serves as a ubiquitin ligase for FEZ1 and thereby regulates its function but not its degradation

  15. A modest association between FEZ1 and Schizophrenia was found.

  16. FEZ1 promotes neurite extension through its interaction with microtubules, and agnoprotein facilitates JCV propagation by inducing the dissociation of FEZ1 from microtubules

  17. the C-terminal regions of FEZ1, and especially its coiled-coil region, are involved in its dimerization, its heterodimerization with FEZ2, and in the interaction with 10 of the identified interacting proteins

  18. Binding of JIP1 and FEZ1 to Kinesin-1 is sufficient to activate the motor for microtubule binding and motility.

  19. We concluded that the missense mutation Asp123Glu of the FEZ1 gene is unlikely to play a substantial role in the genetic susceptibility to schizophrenia.

  20. Data suggest that FEZ1 has an important centrosomal function and supply new mechanistic insights to the formation of flower-like nuclei, which are a phenotypical hallmark of human leukemia cells.

Mouse (Murine) Fasciculation and Elongation Protein zeta 1 (Zygin I) (FEZ1) interaction partners

  1. Phosphorylation of FEZ1 by MARK regulates its function in presynaptic protein trafficking.

  2. Dendrite growth depends on degradation of FEZ1 regulated by Cdc20/APC.

  3. Fezzeta-1 interacts with disrupted in schizophrenia (DISC)1 to synergistically regulate dendritic growth of newborn neurons in the adult mouse hippocampus.

  4. Fez1 is mainly expressed in cortical layers V and VI, not in gamma-aminobutyric acid neurons but in pyramidal neurons, the projection neurons of the cerebral cortex. Immunohistochemistry also shows that Fez1 is expressed in deep layers of the neocortex.

  5. investigated the role of FEZ1 in brain development and the pathogenesis of schizophrenia by generating mice that lack Fez1

Zebrafish Fasciculation and Elongation Protein zeta 1 (Zygin I) (FEZ1) interaction partners

  1. fez1 is crucial for establishing regional subdivisions within the diencephalon and may also play a role in the development of the telencephalon and hypothalamus.

蛋白简介FEZ1

蛋白简介

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.

Gene names and symbols associated with FEZ1

  • fasciculation and elongation protein zeta 1 (FEZ1)
  • fasciculation and elongation protein zeta 1 (zygin I) (Fez1)
  • fasciculation and elongation protein zeta 1 (Fez1)
  • fasciculation and elongation protein zeta 1 (zygin I) (fez1)
  • fasciculation and elongation protein zeta 1 L homeolog (fez1.L)
  • fez1 蛋白
  • UNC-76 蛋白
  • UNC76 蛋白
  • wu:fj14c12 蛋白
  • xfez1 蛋白
  • zgc:73258 蛋白

Protein level used designations for FEZ1

fasciculation and elongation protein zeta-1 , zygin I , zygin-1 , protein kinase C-binding protein Zeta1 , zygin 1 , fasciculation and elongation protein zeta 1 (zygin I) , fasciculation and elongation protein zeta 1 L homeolog

GENE ID SPECIES
9638 Homo sapiens
235180 Mus musculus
81730 Rattus norvegicus
511751 Bos taurus
406705 Danio rerio
444249 Xenopus laevis
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