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Fanconi Anemia, Complementation Group B 蛋白 (FANCB)

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). 再加上，我们可以发Fanconi Anemia, Complementation Group B 抗体 (44)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
FANCB 2187 Q8NB91
FANCB 237211 Q5XJY6
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FANCB 蛋白 by Origin and Source

Origin 在表达 标记
Human ,
,
Mouse (Murine)

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Human Fanconi Anemia, Complementation Group B (FANCB) interaction partners

  1. We identified a 9154 bp intragenic duplication in FANCB (显示 BRCA2 蛋白), covering the first coding exon 3 and the flanking regions. The duplicated allele gives rise to an aberrant transcript containing exon 3 duplication, predicted to introduce a stop codon in FANCB (显示 BRCA2 蛋白) protein (p.A319*).

  2. Four single nucleotide polymorphisms were identified, three of which were located in untranslated regions of Fanconi anemia group B protein (FANCB) and predicted to be associated with normal function.

  3. Loss-of-function FANCB (显示 BRCA2 蛋白) mutations result in a recognizable, multiple malformation phenotype in hemizygous males for which we propose clinical criteria to aid diagnosis.

  4. Inactivation of FancB (显示 BRCA2 蛋白) may play a role in the pathogenesis of sporadic HNSCC.

  5. Elevated serum FA-2 was associated with bony metastases from breast cancer.

  6. the protein defective in individuals with Fanconi anemia belonging to complementation group B is an essential component of the nuclear protein 'core complex' responsible for monoubiquitination of FANCD2

  7. summary of recent advances in the Fanconi anemia (显示 PALB2 蛋白)-BRCA network with emphasis on the new discovery of FAAP95 as the true FANCB (显示 BRCA2 蛋白) gene [review]

  8. Mutations in FANCB (显示 BRCA2 蛋白) are a cause of X linked VACTERL-H syndrome.

  9. Mus81 (显示 MUS81 蛋白) and FANCB (显示 BRCA2 蛋白) have different roles in repair of DNA damage during replication in human cells

  10. Our results rule out a major contribution of FANCB (显示 BRCA2 蛋白) to hereditary breast cancer.

Mouse (Murine) Fanconi Anemia, Complementation Group B (FANCB) interaction partners

  1. Data suggest that Fanconi anemia complementation group B protein (显示 LEPREL2 蛋白) Fancb(-/y) mouse model for studying the Fanconi anemia (显示 PALB2 蛋白) (FA) pathway not only in germ cell development but also in the maintenance of hematopoietic stem cell (HSC (显示 FUT1 蛋白)) function.

  2. FANCB functions at critical stages of germ cell development and reveal a novel function of the FA pathway in the regulation of H3K9 methylation in the germline.

蛋白简介Fanconi Anemia, Complementation Group B (FANCB)

蛋白简介

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group B. Alternative splicing results in two transcript variants encoding the same protein.

Gene names and symbols associated with FANCB

  • Fanconi anemia complementation group B (FANCB)
  • Fanconi anemia, complementation group B (Fancb)
  • BC022692 蛋白
  • FA2 蛋白
  • FAAP90 蛋白
  • FAAP95 蛋白
  • FAB 蛋白
  • FACB 蛋白

Protein level used designations for FANCB

Fanconi anemia group B protein , Fanconi anemia-associated polypeptide of 95 kDa , Fanconi anemia group B protein homolog

GENE ID SPECIES
2187 Homo sapiens
237211 Mus musculus
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