anti-F-Box and WD Repeat Domain Containing 8 (FBXW8) 抗体

FBXW8 encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. 再加上,我们可以发FBXW8 试剂盒 (12)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
FBXW8 26259 Q8N3Y1
FBXW8 304522  
FBXW8 231672 Q8BIA4
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antibodies-online.cn销售最多的anti-FBXW8 抗体

Showing 10 out of 48 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB <b>WB Suggested Anti-FBXW8 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: FBXW8 Antibody [NBP1-84715] - Staining of human cell line A-431 shows positivity in vesicles. Immunohistochemistry-Paraffin: FBXW8 Antibody [NBP1-84715] - Staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells. 0.1 mL Log in to see 7至9个工作日
$491.63
详细
非结合性 EIA, IHC (p), WB FBXW8 Antibody (Center) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. FBXW8 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the FBXW8 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6至8个工作日
$390.50
详细
Bat 非结合性 WB 50 μg Log in to see 7至9个工作日
$551.83
详细
非结合性 FACS, IHC (p), WB FBXW8 Antibody (Center) (ABIN654676) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10至11个工作日
$335.50
详细
Cow 非结合性 WB 50 μg Log in to see 7至9个工作日
$551.83
详细
非结合性 FACS, IHC (p), WB Western blot analysis in Hela cell line lysates (35ug/lane). Western blot analysis in mouse bladder tissue lysates (35ug/lane). 400 μL Log in to see 2至3个工作日
$515.63
详细
小鼠 非结合性 ELISA, WB FBXW8 polyclonal antibody (A01), Lot # UMI10060110QCS1 Western Blot analysis of FBXW8 expression in Hela NE Western Blot detection against Immunogen (37.11 KDa) . 50 μL Log in to see 11至12个工作日
$305.71
详细
非结合性 ELISA, WB 50 μg Log in to see 2至3个工作日
$446.88
详细
非结合性 WB FBXW8 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 2至3个工作日
$473.93
详细

引用最多的anti-FBXW8 抗体

  1. Human Polyclonal FBXW8 Primary Antibody for ELISA, WB - ABIN565252 : Wei, Yang, Chuang, Yang, Kulp, Lu, Lai, Chen: A novel mechanism by which thiazolidinediones facilitate the proteasomal degradation of cyclin D1 in cancer cells. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal FBXW8 Primary Antibody for ICC, IF - ABIN4310808 : Halbach, Stehning, Damrath, Jendrach, Şen, Başak, Auburger: Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated. in PLoS ONE 2015 (PubMed)
    Show all 2 Pubmed References

  3. Cow (Bovine) Polyclonal FBXW8 Primary Antibody for WB - ABIN2786275 : Tsutsumi, Kuwabara, Arai, Xiao, Decaprio: Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice. in Molecular and cellular biology 2008 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal FBXW8 Primary Antibody for FACS, IHC (p) - ABIN654676 : Wang, Chen, Lin, Li, Zhou, Liu, Logsdon, Jin, Abbruzzese, Tan, Wang: The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1. in The Journal of biological chemistry 2014 (PubMed)

更多抗FBXW8的相互作用对抗体

Human F-Box and WD Repeat Domain Containing 8 (FBXW8) interaction partners

  1. FBXW8 and PARK2 (显示 PARK2 抗体) are sequestrated into insolubility by ATXN2 (显示 ATXN2 抗体) PolyQ expansions, but only FBXW8 expression is dysregulated

  2. findings will shed light the role to mechanism of miR (显示 MLXIP 抗体)-218 in regulating JEG-3 cells proliferation via miR (显示 MLXIP 抗体)-218/Fbxw8 axis, and miR (显示 MLXIP 抗体)-218 may serve as a novel potential therapeutic target in human choriocarcinoma in the future

  3. CUL7 (显示 CUL7 抗体)/Fbxw8 ubiquitin ligase-mediated HPK1 (显示 MAP4K1 抗体) degradation revealed a direct link and novel role of CUL7 (显示 CUL7 抗体)/Fbxw8 ubiquitin ligase in the MAPK (显示 MAPK1 抗体) pathway, which plays a critical role in cell proliferation and differentiation.

  4. Dysregulation of Cul7 (显示 CUL7 抗体) and Fbxw8 expression might affect trophoblast turnover in intrauterine growth restriction.

  5. Growth factor-stimulated TBC1D3 (显示 TBC1D3 抗体) ubiquitination and degradation are regulated by its interaction with CUL7 (显示 CUL7 抗体)-Fbw8.

  6. Fbxw8 plays an essential role in the proliferation of human trophoblast cells, especially JEG-3 cells.

  7. FBXW8 plays an essential role in cancer cell proliferation throug (显示 CCND1 抗体)h proteolysis of cyclin D1. It may (显示 CDK1 抗体) present new opportunities to develop therapies targeting destruction of cyclin D1 or its regulator E3 ligase selectively.

  8. FBXW8-CUL7 (显示 CUL7 抗体) complex plays a significant role in growth control

Mouse (Murine) F-Box and WD Repeat Domain Containing 8 (FBXW8) interaction partners

  1. FBXW8 and PARK2 (显示 PARK2 抗体) are sequestrated into insolubility by ATXN2 (显示 ATXN2 抗体) PolyQ expansions, but only FBXW8 expression is dysregulated

  2. mTORC2 (显示 CRTC2 抗体) negatively feeds back to IRS-1 (显示 IRS1 抗体) via control of Fbw8 stability and localization.

  3. our data support the concept that expanded ATXN2 (显示 ATXN2 抗体) undergoes progressive insolubility and affects PABPC1 (显示 PABPC1 抗体) by a toxic gain-of-function mechanism with tissue-specific effects, which may be partially alleviated by the induction of FBXW8.

  4. Depletion of FBXW8 caused a significant accumulation of cyclin D1 (显示 CCND1 抗体), as well as sequestration of CDK1 (显示 CDK1 抗体) in the cytoplasm. This resulted in a severe reduction of cell proliferation.

  5. Cul7 (显示 CUL7 抗体) forms a heterodimeric complex with Cul1 (显示 CUL1 抗体) in a manner dependent on Fbxw8.

  6. FBXW8-CUL7 (显示 CUL7 抗体) complex plays a significant role in growth control

FBXW8 抗原简介

蛋白简介

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with FBXW8

  • F-box and WD repeat domain containing 8 (FBXW8) 抗体
  • F-box and WD repeat domain containing 8 (Fbxw8) 抗体
  • ring finger protein, transmembrane 2 (RNFT2) 抗体
  • F-box and WD-40 domain protein 8 (Fbxw8) 抗体
  • 4930438M06Rik 抗体
  • FBW6 抗体
  • FBW8 抗体
  • Fbx29 抗体
  • FBXO29 抗体
  • FBXW6 抗体

Protein level used designations for FBXW8

F-box and WD-40 domain protein 8 , F-box and WD-40 domain-containing protein 8 , F-box only protein 29 , F-box/WD repeat-containing protein 8 , F-box protein FBX29

GENE ID SPECIES
486288 Canis lupus familiaris
26259 Homo sapiens
787118 Bos taurus
304522 Rattus norvegicus
100728842 Cavia porcellus
101108081 Ovis aries
231672 Mus musculus
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