F-Box and Leucine-Rich Repeat Protein 4 蛋白 (FBXL4)

FBXL4 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. 再加上,我们可以发FBXL4 抗体 (40)FBXL4 试剂盒 (12)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
FBXL4 26235 Q9UKA2
FBXL4 269514 Q8BH70
大鼠 FBXL4 FBXL4 313101  
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
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FBXL4 蛋白 by Origin and Source

Origin 在表达 标记
Human ,
,
Mouse (Murine)

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Human F-Box and Leucine-Rich Repeat Protein 4 (FBXL4) interaction partners

  1. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multisystem disease.

  2. Overall, FBXL4 defects account for at least 0.7% (6 out of 808) of subjects suspected to have a mitochondrial disorder, and as high as 14.3% (4 out of 28) in young children with congenital lactic acidosis and clinical features of mitochondrial disease. Including FBLX4 in the mitochondrial diseases panel should be particularly important for patients with congenital lactic acidosis

  3. On clinical indication of mitochondrial encephalomyopathy, sequencing of FBXL4 should be performed, even when the activity levels of the MRC enzymes are normal

  4. A clinical pattern of early-onset encephalopathy, persistent lactic acidosis, profound muscular hypotonia and typical facial dysmorphism should prompt initiation of molecular genetic analysis of FBXL4.

  5. Mutations in FBXL4 are disease causing and establish FBXL4 as a mitochondrial protein (显示 COX6B2 蛋白) with a possible role in maintaining mtDNA integrity and stability.

  6. These data strongly support a role for FBXL4 in controlling bioenergetic homeostasis and mtDNA maintenance.

  7. SKP1 (显示 SKP1 蛋白)-Cul1 (显示 CUL1 蛋白)-F-box and leucine-rich repeat protein 4 (SCF (显示 KITLG 蛋白)-FbxL4) ubiquitin ligase regulates lysine demethylase (显示 MBD2 蛋白) 4A (KDM4A)/Jumonji domain-containing 2A (显示 KDM4A 蛋白) (JMJD2A (显示 KDM4A 蛋白)) protein

Fruit Fly (Drosophila melanogaster) F-Box and Leucine-Rich Repeat Protein 4 (FBXL4) interaction partners

  1. This study uncovered a critical molecular linkage between the circadian clock and the electrical activity of pacemaker neurons and demonstrated that CLOCK-dependent Fbxl4 expression rhythmically downregulates GABAA (显示 GABRg1 蛋白) receptor level to increase the activity of pacemaker neurons and promote wakefulness.

  2. Calmodulin/CAMTA/Fbxl4 may mediate a long-term feedback regulation of the activity of Ca(2 (显示 CA2 蛋白)+)-stimulating G protein-coupled receptor (显示 GPBAR1 蛋白), which could prevent cell damage due to extra Ca(2 (显示 CA2 蛋白)+) influx.

蛋白简介FBXL4

蛋白简介

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least 9 tandem leucine-rich repeats.

Gene names and symbols associated with FBXL4

  • F-box and leucine rich repeat protein 4 (FBXL4)
  • F box and leucine-rich-repeat gene 4 (Fbxl4)
  • F-box and leucine-rich repeat protein 4 (Fbxl4)
  • F-box and leucine-rich repeat protein 4 (fbxl4)
  • F-box and leucine-rich repeat protein 4 (FBXL4)
  • F-box/LRR-repeat protein 4 (LOC551738)
  • F-box and leucine rich repeat protein 4 (fbxl4)
  • F-box/RNI-like superfamily protein (AT4G15475)
  • 4732456I21 蛋白
  • AI836810 蛋白
  • CG1839 蛋白
  • dFbxl4 蛋白
  • Dmel\\CG1839 蛋白
  • FBL4 蛋白
  • FBL5 蛋白
  • FBXL4 蛋白
  • GB14438 蛋白
  • zgc:92297 蛋白

Protein level used designations for FBXL4

F-box/LRR-repeat protein 4 , F-box and leucine-rich repeat protein 4 , CG1839-PA , Fbxl4-PA , F box and leucine-rich-repeat gene 4 , F-box/LRR-repeat protein 4-like , f-box/LRR-repeat protein 4-like

GENE ID SPECIES
26235 Homo sapiens
462894 Pan troglodytes
693683 Macaca mulatta
32378 Drosophila melanogaster
269514 Mus musculus
313101 Rattus norvegicus
421798 Gallus gallus
481932 Canis lupus familiaris
492349 Danio rerio
535452 Bos taurus
551738 Apis mellifera
100027180 Monodelphis domestica
100066051 Equus caballus
100392659 Callithrix jacchus
100457811 Pongo abelii
100468171 Ailuropoda melanoleuca
100549816 Meleagris gallopavo
100552837 Anolis carolinensis
100603611 Nomascus leucogenys
101104499 Ovis aries
827219 Arabidopsis thaliana
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