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DNA helicase that acts as an essential component of the spindle assembly checkpoint. 再加上，我们可以发Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6-Like 蛋白 (3) 和 和数多这个蛋白质的别的产品。
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Human Polyclonal ERCC6L Primary Antibody for WB - ABIN527207
Laulier, Cheng, Stark: The relative efficiency of homology-directed repair has distinct effects on proper anaphase chromosome separation. in Nucleic acids research 2011
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Human Monoclonal ERCC6L Primary Antibody for ELISA, WB - ABIN565778
Leng, Bessuso, Jung, Wang, Qin: Targeting Plk1 to chromosome arms and regulating chromosome compaction by the PICH ATPase. in Cell cycle (Georgetown, Tex.) 2008
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Human Polyclonal ERCC6L Primary Antibody for WB - ABIN527205
Nera, Huang, Lai, Xu: Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions. in Nature communications 2015
These findings suggested that ERCC6L, which is highly expressed in breast cancer, acts as an oncogene (显示 RAB1A 抗体), is involved in breast cancer development and may serve as a novel molecular target for the treatment of breast cancer.
ERCC6L may stimulates cancer cell proliferation by promoting cell cycle through a way of RAB31 (显示 RAB31 抗体)-MAPK (显示 MAPK1 抗体)-CDK2 (显示 CDK2 抗体), and it could be a potential biomarker for cancer prognosis and target for cancer treatment.
Data indicate BEND3 as a new interaction partner for PICH in mitosis, and have defined the residues within a TPR-BEN domain interface that mediate this interaction.
Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex has been reported.
a novel SUMO-dependent regulation of PICH's function on mitotic centromeres, is reported.
PICH and Topo II (显示 TOP2 抗体) cooperate to prevent chromosome missegregation events in mitosis.
PICH is a SUMO-interacting protein and a mitotic SUMO substrate.
PICH binds to BLM (显示 BLM 抗体) and enables BLM (显示 BLM 抗体) localization to anaphase centromeric threads. PICH and BLM (显示 BLM 抗体) unravel centromeric chromatin and keep anaphase DNA threads mostly free of nucleosomes.
the PICH-Plk1 complex plays a critical role in maintaining prometaphase chromosome architecture
the spindle checkpoint failure formerly attributed to the depletion of PICH most likely reflects an off-target effect that causes the lowering of Mad2 (显示 MAD2L1 抗体) transcript and protein.
DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase.
ATP-dependent helicase ERCC6-like
, DNA excision repair protein ERCC-6-like
, Plk1-interacting checkpoint helicase
, SNF2/RAD54 family protein
, excision repair cross-complementing rodent repair deficiency complementation group 6 - like
, excision repair protein ERCC6-like
, tumor antigen BJ-HCC-15
, excision repair cross-complementing rodent repair deficiency complementation group 6-like
, excision repair cross-complementing rodent repair deficiency, complementation group 6-like