Eukaryotic Translation Initiation Factor 4 Gamma, 1 蛋白 (EIF4G1)

The protein encoded by EIF4G1 is a component of the multi-subunit protein complex EIF4F. 再加上,我们可以发Eukaryotic Translation Initiation Factor 4 Gamma, 1 抗体 (175)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
EIF4G1 1981 Q04637
大鼠 EIF4G1 EIF4G1 287986  
EIF4G1 208643 Q6NZJ6
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
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EIF4G1 蛋白 by Origin and Source

Origin 在表达 标记
Human , , ,
, ,
Mouse (Murine)

引用最多的Eukaryotic Translation Initiation Factor 4 Gamma, 1 蛋白

  1. Human EIF4G1 Protein expressed in HEK-293 Cells - ABIN2720102 : Liberman, Gandin, Svitkin, David, Virgili, Jaramillo, Holcik, Nagar, Kimchi, Sonenberg: DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation. in Nucleic acids research 2015 (PubMed)

  2. Human EIF4G1 Protein expressed in Wheat germ - ABIN1352615 : Arif, Jia, Mukhopadhyay, Willard, Kinter, Fox: Two-site phosphorylation of EPRS coordinates multimodal regulation of noncanonical translational control activity. in Molecular cell 2009 (PubMed)

更多Eukaryotic Translation Initiation Factor 4 Gamma, 1 (EIF4G1)互动伙伴

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 4 Gamma, 1 (EIF4G1) interaction partners

  1. The structures of eIF4E-eIF4G complexes reveal an extended interface to regulate translation initiation.

  2. Phosphorylation of 4E-BP1 impairs the competition with eIF4G for eIF4E binding.

  3. The eIF4G knockdown did not affect male fertility.

  4. Data show that in the early embryo dFMRP associates specifically with Caprin, and with eIF4G, a key regulator of translational initiation.

  5. A novel eIF4G homolog, Off-schedule, couples translational control to meiosis and differentiation in Drosophila spermatocytes.

Arabidopsis thaliana Eukaryotic Translation Initiation Factor 4 Gamma, 1 (EIF4G1) interaction partners

  1. eIFiso4G expression is required to regulate violaxanthin de-epoxidase expression and to support photosynthetic activity.

  2. coordinated and selective recruitment of eIF4E and eIF4G factors at a very early step in potyvirus infection

Human Eukaryotic Translation Initiation Factor 4 Gamma, 1 (EIF4G1) interaction partners

  1. MET-eIF4G1-HIF-1alpha pathway is further supported by a co-occurrence of their expression.

  2. Lack of regulation of the interaction between the eIF4E/eIF4G subunits of the translation initiation factor complex eIF4F is a hallmark of cancer. The inhibitor 4EGI-1 binds to eIF4E, thereby preventing association with eIF4G through an allosteric mechanism. Binding of 4EGI-1 perturbs native correlated motions and increases correlated fluctuations in part of the eIF4G binding site.

  3. The polymorphism of the rs200221361 may have no association with the occurrence of Parkinson disease in Uygur and Han people of Xinjiang.

  4. Epstein-Barr Virus protein EB2 first is recruited to the mRNA cap structure in the nucleus and then interacts with the proteins eIF4G and PABP to enhance the initiation step of translation.

  5. EIF4G1 overexpression is associated with non-small cell lung cancers.

  6. High EIF4G expression is associated with malignant peripheral nerve sheath tumors and vestibular schwannomas.

  7. The structures of eIF4E-eIF4G complexes reveal an extended interface to regulate translation initiation.

  8. The study indicates that the EIF4G1 mutation is rare in Taiwan, which is consistent with other reports from Asia. Ethnicity could have a great influence on EIF4G1 in Parkinson's disease.

  9. the IRES of encephalomyocarditis virus (EMCV) interacts with the HEAT-1 domain of eukaryotic initiation factor 4G (eIF4G).

  10. Data show that targeting translation initiation (TI) factors eIF4E/eIF4GI reduces migration and epithelial-to-mesenchymal transition (EMT), both essential for metastasis, thereby underscoring the potential of TI targeting in non-small cell lung cancer (NSCLC) therapy.

  11. EIF4G1 mutations are not related to Parkinson's disease

  12. VPS35 D620N and EIF4G1 R1205H mutations are not a common cause of Parkinson disease in the Greek population.

  13. This study is the first to directly assess the relative contribution of eIF4F components to the expressed cellular proteome, transcription factors, microRNAs, and phenotype in multiple myeloma

  14. EIF4GI shares this activity and also interacts with eIF1.

  15. the C-terminal extension (motif 3) is critical to 4E-BP1-mediated cell cycle arrest and it partially overlaps with the binding site of 4EGI-1

  16. EIF4G1 is neither a strong nor a common risk factor for Parkinson's disease: evidence from large European cohorts.

  17. This study therefore implicates c-Myc as a potential regulator of the cancer-promoting effects of equol via up-regulation of eIF4GI and selective initiation of translation on mRNAs that utilize non-canonical initiation, including certain oncogenes

  18. Knockdown of eIF4GI was deleterious to myeloma cells phenotype and expression of specific molecular targets (SMAD5/ERalpha/HIF1alpha/c-Myc).

  19. Its mutation is not a common cause of familial Parkinson's disease.

  20. in a generic cell model, new insights into the mechanisms whereby the FSH receptor controls translation have been gained. Rapamycin-sensitive eIF4G phosphorylation at the 5' cap may be a surrogate for the classical exchange between eIF4G and 4E-BP1.

Mouse (Murine) Eukaryotic Translation Initiation Factor 4 Gamma, 1 (EIF4G1) interaction partners

  1. Our studies reveal unexpected genetic and functional interactions between VPS35 and EIF4G1, two seemingly unrelated PD genes, and functionally connect them to alpha-synuclein pathobiology in yeast, worms, and mouse.

  2. Disruption of insulin receptor (IR) expression in beta cells has a direct impact on the expression of the convertase enzyme carboxypeptidase E (CPE) by inhibition of the eukaryotic translation initiation factor Eif4g1.

  3. Data indicate that MNK2 plays a unique role, not shared by its closest paralog MNK1, in limiting protein translation through its negative effect on eIF4G Ser1108 phosphorylation and p70S6K activation.

  4. expression of 3e5 diminishes eIF4G interaction with eIF3 and causes abnormal gene expression at the translational level.

  5. findings assign NAD(P)H quinone-oxydoreductase 1 an original role in the regulation of mRNA translation via the control of eIF4GI stability by the proteasome.

  6. downregulated expression in T cells following treatment with bis(tri-n-butylin)oxide (TBTO), an immunotoxic organotin compound

  7. eIF4G binding to Mnk is inhibted by Mnk1 phosphorylation by caspase-activated Pak2/gamma-PAK

  8. Comparison of the p53-induced patterns of eIF4GI and 4E-BP1 dephosphorylation and cleavage with those caused by the mammalian target of rapamycin inhibitor rapamycin

  9. These findings suggest that the ability of cells to rephosphorylate 4E-BP1, resynthesise eIF4GI and restore the rate of protein synthesis after inactivation of p53 is an important aspect of recovery following the relief of physiological stress.

  10. interactions between Pdcd4 and components of the translation initiation complex, namely, the RNA helicase eIF4A and the scaffolding protein eIF4G

  11. analysis of cells of eIF4GIf molecules lacking either the PABP-binding site, the eIF3-binding site, the middle domain eIF4A-binding site, or the C-terminal segment that includes the second eIF4A-binding site

  12. Poly(A) binding protein (PABP) is identified as an Msi1-binding protein, and Msi1 competes with eIF4G for PABP binding.

蛋白简介Eukaryotic Translation Initiation Factor 4 Gamma, 1 (EIF4G1)

蛋白简介

The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.

Gene names and symbols associated with EIF4G1

  • eukaryotic translation initiation factor 4 gamma 1 (EIF4G1)
  • eukaryotic translation initiation factor 4G (eIF4G)
  • eukaryotic translation initiation factor 4 gamma, 1a (eif4g1a)
  • eukaryotic translation initiation factor 4 gamma 1 (LOC704923)
  • eukaryotic translation initiation factor 4 gamma, 1 S homeolog (eif4g1.S)
  • eukaryotic translation initiation factor 4G (EIF4G)
  • eukaryotic initiation factor (EIF4G)
  • eukaryotic translation initiation factor 4 gamma (eIF4g)
  • eukaryotic translation initiation factor 4 gamma (Eif4g)
  • eukaryotic translation initiation factor 4 gamma, 1 (Eif4g1)
  • eukaryotic translation initiation factor 4, gamma 1 (Eif4g1)
  • CG10811 蛋白
  • CUCUMOVIRUS MULTIPLICATION 2 蛋白
  • CUM2 蛋白
  • DDBDRAFT_0217646 蛋白
  • DDBDRAFT_0217647 蛋白
  • DDBDRAFT_0234257 蛋白
  • DDB_0217646 蛋白
  • DDB_0217647 蛋白
  • DDB_0234257 蛋白
  • deIF4G 蛋白
  • Dmel\\CG10811 蛋白
  • E030015G23Rik 蛋白
  • eIF-4G 蛋白
  • EIF-4G1 蛋白
  • EIF4F 蛋白
  • eif4g 蛋白
  • EIF4G1 蛋白
  • eIF4GI 蛋白
  • eukaryotic translation initiation factor 4G 蛋白
  • NV18824 蛋白
  • p200 蛋白
  • p220 蛋白
  • PARK18 蛋白
  • wu:fb50a05 蛋白
  • wu:fc60b06 蛋白

Protein level used designations for EIF4G1

eukaryotic translation initiation factor 4 gamma 1 , CG10811-PA , CG10811-PB , CG10811-PC , Eukaryotic-initiation-factor-4G , eIF-4G , eIF4G-PA , eIF4G-PB , eIF4G-PC , eukaryotic initiation factor 4G , translation initiation factor , translation initiation factor eIF4G , eukaryotic translation initiation factor 4 gamma, 1 , fb50a05 , eukaryotic initiation factor , eukaryotic translation initiation factor 4 gamma , eukaryotic translation initiation factor 4 gamma 1-like , EIF4-gamma , eIF-4-gamma 1 , eucaryotic translation initiation factor 4G , eIF-4G 1 , eIF-4G1

GENE ID SPECIES
449528 Sus scrofa
100033975 Equus caballus
43839 Drosophila melanogaster
424953 Gallus gallus
460888 Pan troglodytes
572435 Danio rerio
704923 Macaca mulatta
733162 Xenopus laevis
825194 Arabidopsis thaliana
5718605 Chlamydomonas reinhardtii
8246969 Micromonas sp. RCC299
8619923 Dictyostelium discoideum AX4
9688587 Micromonas pusilla CCMP1545
100083863 Ornithorhynchus anatinus
100115514 Nasonia vitripennis
100391519 Callithrix jacchus
100470670 Ailuropoda melanoleuca
1981 Homo sapiens
100009384 Oryctolagus cuniculus
287986 Rattus norvegicus
208643 Mus musculus
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