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Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.. 再加上，我们可以发ELL2 抗体 (57) 和 和数多这个蛋白质的别的产品。
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These results suggest that ELL2 and its pathway genes likely play an important role in the development and progression of prostate cancer.
Deletion of the Ell2 gene in mice results in loss of Ig secretion from plasma cells and reduced expression of a number of other genes involved in secretion and the unfol (显示 XBP1 蛋白)ded pr (显示 ATF6 蛋白)otein (显示 HSPA5 蛋白) response l (显示 CCNB2 蛋白)ike XBP1, Oc (显示 POU2AF1 蛋白)aB (BOB1, (显示 POU2AF1 蛋白) Pou2af1), cyclin B2 and Ig light chain
The splicing factor hnRNPLL and the transcription elongation factor ELL2 modulate the ratio of secred versus membrane-encoding Ighg2b transcripts at the expense of the secreted isoform.
ELL2 enhanced both polyadenylation and exon skipping with the gene encoding the immunoglobulin heavy-chain complex (Igh) and reporter constructs
Study reports the 2.0-A resolution crystal structure of the human ELL2 C-terminal domain bound to its 50-residue binding site on AFF4 (显示 AFF4 蛋白), the ELLBow. The ELLBow consists of an N-terminal helix followed by an extended hairpin and occupies most of the concave surface of ELL2. This surface is important for the ability of ELL2 to promote HIV-1 Tat (显示 TAT 蛋白)-mediated proviral transcription.
Knockdown of RNA polymerase II elongation factor ELL2 (ELL2) sensitized prostate cancer cells to DNA damage and overexpression of ELL2 protected prostate cancer cells from DNA damage.
Results provide the first evidence that ELL2 is a direct target of miR (显示 MLXIP 蛋白)-299 and increased ELL2 expression and down-regulation of miR (显示 MLXIP 蛋白)-299 are associated with GBM progression and poor prognosis in patients.
Selective expression of the transcription elongation factor (显示 TSFM 蛋白) ELL3 (显示 ELL3 蛋白) in B cells prior to ELL2 drives proliferation and survival
multiple myeloma risk allele harbours a Thr298Ala missense variant in an ELL2 domain required for transcription elongation
Tax (显示 CNTN2 蛋白) transactivates the ELL2 promoter in HTLV-1-infected T-cells.
Loss of ELL2 in B cells results in decreased Igh secretory mRNA and decreased expression of Ig light chain plus genes involved in the unfolded protein response like XBP1 (显示 XBP1 蛋白), ATF6 (显示 ATF6 蛋白), BiP (显示 GDF10 蛋白), cyclin B2 (显示 CCNB2 蛋白), OcaB (BOB1 (显示 POU2AF1 蛋白), Pou2af1 (显示 POU2AF1 蛋白)).
Prostratin and HMBA, two well-studied activators of HIV transcription and latency, enhance ELL2 accumulation and SECs formation largely through decreasing Siah1 (显示 SIAH1 蛋白) expression and ELL2 polyubiquitination.
ELL2 addition regulates mRNA processing by enhancing poly(A) site choice and exon splice-site skipping
Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.
RNA polymerase II elongation factor ELL2
, elongation factor, RNA polymerase II, 2
, elongation factor, RNA polymerase 2, 2
, RNA polymerase II elongation factor ELL2-like
, ELL-related RNA polymerase II, elongation factor
, eleven-nineteen lysine-rich leukemia gene 2