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Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family (By similarity). 再加上，我们可以发ELMO/CED-12 Domain Containing 1 抗体 (33) 和 和数多这个蛋白质的别的产品。
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Data suggest that GPR124 promotes cell adhesion via interaction with Elmo1 (显示 ELMO1 蛋白)-Dock180 (显示 DOCK1 蛋白) and intersectin 1 (显示 ITSN1 蛋白)/2; this constitutes a previously unrecognized heteromeric complex that is putatively involved in GPR124-dependent adhesive/angiogenic responses in vascular endothelial cells. (GPR124 = G-protein coupled receptor 124; Elmo1 (显示 ELMO1 蛋白) = ELMO domain-containing protein 1; Dock180 (显示 DOCK1 蛋白) = dedicator of cytokinesis protein 1 (显示 DOCK1 蛋白) 180 kDa)
The non-opioid sigma-1 receptor (S1R) was identified as a novel effector of GAP activity of ELMOD1-3 proteins as its direct binding to either ELMOD1 or ELMOD2 (显示 ELMOD2 蛋白) resulted in loss of GAP activity.
Elmod1 has relatively high and selective expression in the brain but as of 2014 has not been well-studied with respect to CNS function or disease associations. It is part of the core brain ignorome. Elmod1 has a high cis (显示 CISH 蛋白)-eQTL (显示 EQTN 蛋白) in hippocampus, hypothalamus, striatum. Hearing sensitivity trait in GeneNetwork.org also maps to the region containing Elmod1.
This finding connecting ELMOD1 deficiencies with stereocilia dysmorphologies establishes a link between the Ras superfamily of small regulatory GTPases and the actin cytoskeleton dynamics of hair cell stereocilia.
Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family (By similarity).
ELMO domain containing 1
, ELMO domain-containing protein 1