anti-EF-Hand Domain Family, Member D2 (EFHD2) 抗体

May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity). 再加上,我们可以发EF-Hand Domain Family, Member D2 试剂盒 (10)EF-Hand Domain Family, Member D2 蛋白 (6)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
EFHD2 79180 Q96C19
EFHD2 298609 Q4FZY0
EFHD2 27984  
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Showing 10 out of 47 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-EFHD2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Human Lung 100 μL Log in to see 2至3个工作日
$289.00
详细
山羊 非结合性 ELISA, WB ABIN185311 (0.1µg/ml) staining of human lymph node lysate. Primary incubation was 1 hour. Detected by chemiluminescence. ABIN185311 (0.3µg/ml) staining of paraffin embedded human tonsil. Microwaved antigen retrieval with citrate buffer pH6, HRP-staining. Positive cells A) in the interfollicular area and surrounding a vessel, B) in proximity of the epithelial criptae. 100 μg Log in to see 6至7个工作日
$358.02
详细
山羊 非结合性 IHC (p), IHC, ELISA, WB ABIN250320 (0.03µg/ml) staining of Human Thymus lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. ABIN250320 (0.3?g/ml) staining of paraffin embedded Human Tonsil. Microwaved antigen retrieval with citrate buffer pH6, HRP-staining. Positive cells A) in the interfollicular area and surrounding a vessel, B) in proximity of the epithelial criptae. 0.1 mg Log in to see 7至9个工作日
$485.88
详细
非结合性 WB 50 μg Log in to see 7至9个工作日
$551.83
详细
Cow 山羊 非结合性 ELISA, IHC, IHC (p), WB 100 μg Log in to see 7至9个工作日
$610.50
详细
非结合性 IHC, IHC (p), WB Western Blot: EFHD2 Antibody [NBP2-13947] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Human cell line RT-4 Immunohistochemistry-Paraffin: EFHD2 Antibody [NBP2-13947] - Staining of human lymph node shows strong cytoplasmic positivity in a subset of non-germinal center cells. 0.1 mL Log in to see 10至13个工作日
$491.63
详细
非结合性 IHC, IHC (fro), WB Western Blot: EFHD2 Antibody [NBP1-31134] - Western blot analysis of EFHD2 Antibody on: A:H1299 10% SDS PAGE diluted at 1:1000 0.1 mL Log in to see 8至11个工作日
$514.63
详细
非结合性 ELISA, IHC, IHC (p), WB Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 11至14个工作日
$484.00
详细
山羊 非结合性 IHC (p), WB   0.1 mg Log in to see Available
$462.00
详细
非结合性 EIA, IHC (p), WB Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 6至8个工作日
$390.50
详细

引用最多的anti-EF-Hand Domain Family, Member D2 抗体

  1. Human Polyclonal EFHD2 Primary Antibody for IHC (p), IHC - ABIN250320 : Ferrer-Acosta, Rodríguez-Cruz, Orange, De Jesús-Cortés, Madera, Vaquer-Alicea, Ballester, Guinel, Bloom, Vega: EFhd2 is a novel amyloid protein associated with pathological tau in Alzheimer's disease. in Journal of neurochemistry 2013 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal EFHD2 Primary Antibody for ELISA, WB - ABIN185311 : Vuadens, Rufer, Kress, Corthésy, Schneider, Tissot: Identification of swiprosin 1 in human lymphocytes. in Proteomics 2004 (PubMed)
    Show all 3 Pubmed References

更多抗EF-Hand Domain Family, Member D2的相互作用对抗体

Human EF-Hand Domain Family, Member D2 (EFHD2) interaction partners

  1. Data demonstrate that EFhd2 shows unique structural and biological features as an EF-hand containing F-actin bundling protein. For F-actin bundling activity, structural stabilization of the EF-hand domains was found to occur in the presence of Ca2 (显示 CA2 抗体)+. The core region of EFhd2 maintains its structure in the absence of Ca2 (显示 CA2 抗体)+ ; however, changes in local conformational flexibility reduce F-actin bundling activity of EFhd2.

  2. Phosphorylation at Ser183 of EFhd2 causes changes in the local conformational dynamics and the surface charge distribution of the actin-binding site, resulting in a re-coordination of the actin-binding sites in the dimer structure.

  3. The results imply that EFhd2's physiological and/or pathological function could be regulated by its phosphorylation state.

  4. EFhd2 is involved in the control of synapse development and maintenance and is linked to dementia.

  5. Swiprosin-1 localizes to microvilli-like membrane protrusions and lamellipodia and exhibits actin-binding activity.

  6. Swiprosin-1 is involved in regulating the accessibility of F-actin to cofilin (显示 CFL1 抗体) through the clustering of F-actin and the activity of Swiprosin-1 is highly dependent on its phosphorylation status at Ser183

  7. EFhd2 may play an important role in the pathobiology of tau-mediated neurodegeneration.

  8. the human Shu complex (hSWS1.SWSAP1 (显示 SWSAP1 抗体)) has an evolutionarily conserved function in homologous recombination

  9. Its predominant presence in CD8 (显示 CD8A 抗体) lymphocytes suggests that swiprosin-1 may be involved in functions that are important for cytotoxic lymphocytes.

  10. These results suggest that swiprosin-1 is a PKC-beta (显示 PRKCB 抗体) I/eta-inducible gene and it modulates mast cell activation through NF-kappaB (显示 NFKB1 抗体)-dependent pathway.

Mouse (Murine) EF-Hand Domain Family, Member D2 (EFHD2) interaction partners

  1. These results indicate that swiprosin-1 in the vestibular nuclei is a critical determinant of the susceptibility to motion sickness.

  2. this study shows that EFhd2/swiprosin-1 regulates LPS (显示 TLR4 抗体)-induced macrophage recruitment via enhancing actin polymerization and cell migration

  3. These results show that EFhd2 is not essential for platelet function in mice indicating that other cytoskeletal adaptors may functionally compensate its loss.

  4. EFhd2 is a neuronal protein that interferes with kinesin-mediated transport.

  5. a role is found for EFhd2 as a negative regulator of germinal center-dependent humoral type 2 immunity, with implications for the generation of IgE.

  6. Swiprosin-1 is involved in regulating the accessibility of F-actin to cofilin (显示 CFL1 抗体) through the clustering of F-actin and the activity of Swiprosin-1 is highly dependent on its phosphorylation status at Ser183

  7. Characterized EFhd2's calcium binding activity. Results showed mutations of a conserved aspartate on either EF-hand motif disrupted calcium binding activity, indicating that these motifs work in pair as a functional calcium binding domain.

  8. EFhd2 may play an important role in the pathobiology of tau-mediated neurodegeneration.

  9. Swip-1 (显示 WSB1 抗体) provides a membrane scaffold that is required for the Syk (显示 SYK 抗体)-, SLP-65 (显示 BLNK 抗体)-, and PLCgamma2 (显示 PLCG2 抗体)-dependent BCR (显示 BCR 抗体)-induced calcium flux.

  10. study shows that swiprosin-1 may regulate lifespan and BCR (显示 BCR 抗体) signaling thresholds in immature B cells

EF-Hand Domain Family, Member D2 (EFHD2) 抗原简介

蛋白简介

May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity). Plays a role as negative regulator of the canonical NF-kappa-B-activating branch (By similarity). Controls spontaneous apoptosis through the regulation of BCL2L1 abundance (By similarity).

Gene names and symbols associated with EFHD2

  • EF-hand domain family member D2 (EFHD2) 抗体
  • EF-hand domain family, member D2 (Efhd2) 抗体
  • EF-hand domain family member D2 (efhd2) 抗体
  • EF-hand domain family member D2 L homeolog (efhd2.L) 抗体
  • EF hand domain containing 2 (Efhd2) 抗体
  • EF-hand domain family, member D2 (efhd2) 抗体
  • 2600015J22Rik 抗体
  • AA408606 抗体
  • D4Wsu27e 抗体
  • EFHD2 抗体
  • MGC131292 抗体
  • si:dkey-72l14.9 抗体
  • SWS1 抗体
  • wu:fb80e07 抗体

Protein level used designations for EFHD2

EF hand domain containing 2 , EF hand domain family, member D2 , EF-hand domain-containing protein D2 , swiprosin 1 , swiprosin-1 , EF-hand domain family, member D2

GENE ID SPECIES
79180 Homo sapiens
298609 Rattus norvegicus
430669 Gallus gallus
496711 Xenopus (Silurana) tropicalis
514259 Bos taurus
694155 Macaca mulatta
735013 Xenopus laevis
747200 Pan troglodytes
100345208 Oryctolagus cuniculus
27984 Mus musculus
100380618 Salmo salar
571114 Danio rerio
607254 Canis lupus familiaris
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