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Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. 再加上，我们可以发Dynein, Cytoplasmic 1, Light Intermediate Chain 1 蛋白 (5) 和 和数多这个蛋白质的别的产品。
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the DYNC1I1 deficiency, a neuron-specific dynein intermediate chain, causes neuronal atrophy in primary hippocampal neurons.
Light intermediate chain 1 is required for single-cell polarization and directional cell motility.
conserved mechanism of effector interaction with dynein-dynactin necessary for processive motility
This work reveals the structural details of Hook3's interaction with dynein and offers insight into how cargo adaptors form processive dynein-dynactin motor complexes.
although dynein lacking light intermediate chains (LICs) drives microtubule gliding at normal rates, the LICs are required for the formation and maintenance of a bipolar spindle.
using a variety of complementary approaches, our results indicate a novel specific role for the LICs in dynein recruitment to components of the late endocytic pathway.
Rab11a, FIP3 and DLIC-1 form a ternary complex and DLIC-1 colocalises with endogenous FIP3 and Rab11a in A431 cells.
Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress throuh the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores (By similarity).
, cytoplasmic dynein 1 light intermediate chain 1
, dynein light chain A
, dynein light intermediate chain 1, cytosolic
, dynein, cytoplasmic, light intermediate chain 1
, dynein, cytoplasmic, light intermediate polypeptide 1
, dynein light chain-A
, dyenin light chain A