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The protein encoded by DGKA belongs to the eukaryotic diacylglycerol kinase family. 再加上，我们可以发DGKA 抗体 (112) 和 DGKA 试剂盒 (10)和数多这个蛋白质的别的产品。
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Our studies demonstrate that PKD1 (显示 PKD1 蛋白)/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha effect on MVB secretory traffic.
Diacylglycerol kinase alpha establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse.
Ovalbumin (显示 OVA 蛋白)-induced airway inflammation was inhibited after DGKalpha DNA vaccine administation.
Data indicate that combined deletion of dgkzeta (显示 DGKZ 蛋白) and dgkalpha markedly enhances T-cell responses.
The data strongly supported a role for FoxO (显示 FOXO3 蛋白) proteins in promoting high diacylglycerol kinase alpha levels and indicate a mechanism by which diacylglycerol kinase alpha function is downregulated during productive T cell responses.
results suggest that the globular form of adiponectin-induced generation of reactive oxygen species and nitric oxide involves diacylglycerol kinase alpha
DAG kinases (DGKs) alpha and zeta, which terminate DAG-mediated signaling, synergistically inhibit TCR-induced mTOR (显示 FRAP1 蛋白) activation by inhibiting the Ras-Mek1 (显示 MAP2K1 蛋白)/2-Erk (显示 EPHB2 蛋白)/12 pathway
A role for DGK alpha in T cell activation is confirmed by the rapid DGK alpha translocation to the membrane fraction, together with the increase in enzyme activity that follows T cell activation in vivo.
regulated by pi 3 (显示 PI3 蛋白)-kinase activation products
Diacylglycerol kinase alpha is an anergy-associated molecule that negatively regulates Ras in anergic T cells.
An abandoned compound that also inhibits serotonin receptors may have more translational potential as a DGKa inhibitor, but more potent and specific DGKa inhibitors are sorely needed
Decreased DNA methylation (显示 HELLS 蛋白) at this enhancer enables recruitment of the profibrotic transcription factor early growth response 1 (EGR1 (显示 EGR1 蛋白)) and facilitates radiation-induced DGKA transcription in cells from patients later developing fibrosis.
These data indicates the existence of a SDF-1alpha induced DGKalpha - atypical PKC - beta1 integrin signaling pathway, which is essential for matrix invasion of carcinoma cells.
DGKalpha generates phosphatidic acid to drive its own recruitment to tubular recycling endosomes via its interaction with MICAL-L1 (显示 MICALL1 蛋白)
High diacylglycerol kinase alpha expression is associated with glioblastoma.
DGKalpha is involved in hepatocellular carcinoma progression by activation of the MAPK (显示 MAPK1 蛋白) pathway.
DGK-alpha was more highly expressed in CD8 (显示 CD8A 蛋白)-tumor-infiltrating T cellscompared with that in CD8non-tumor kidney-infiltrating lymphocytes.
Antigen-specific CD8 (显示 CD8A 蛋白)-positive T cells from DGKalpha-deficient transgenic mice show enhanced expansion and increased cytokine production after lymphocytic choriomeningitis virus infection, yet DGK (显示 DGKB 蛋白)-deficient memory CD8 (显示 CD8A 蛋白)+ T cells exhibit impaired expansion.
SAP (显示 APCS 蛋白)-mediated inhibition of DGKalpha sustains diacylglycerol signaling, thereby regulating T cell activation
Diacylglycerol kinase alpha is a key regulator of the polarised secretion of exosomes.
the nucleo-cytoplasmic shuttling of DGKalpha is orchestrated by tyrosine phosphorylation by the Src-activated tyrosine kinase c-Abl
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
80 kDa diacylglycerol kinase
, DAG kinase alpha
, diacylglycerol kinase alpha
, diglyceride kinase alpha
, diacylglycerol kinase alpha Flt2-Pr2
, truncated diacylglycerol kinase alpha Flt1-Pr1
, diacylglycerol kinase, alpha 80kDa
, diacylglycerol kinase alpha-like