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CDT2/RAMP 蛋白

(Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL))

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).

recommended

CDT2/RAMP Protein (AA 1-730) (Strep Tag) (ABIN3092255)

Crystallography grade DTL 宿主: 人宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB

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recommended

CDT2/RAMP Protein (AA 1-729) (Strep Tag) (ABIN3134980)

Crystallography grade DTL 宿主: 小鼠宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB

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recommended

CDT2/RAMP Protein (GST tag,His tag) (ABIN5505614)

DTL 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD

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CDT2/RAMP 蛋白 by Grade

Find CDT2/RAMP 蛋白 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

CDT2/RAMP 蛋白 by Origin

Find CDT2/RAMP 蛋白 for a variety of species such as anti-Human CDT2/RAMP, anti-Mouse CDT2/RAMP. The species listed below are among those available. Click on a link to go to the corresponding products.

CDT2/RAMP 蛋白 by Source

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CDT2/RAMP 蛋白 by 蛋白类型

Here you can find CDT2/RAMP 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

CDT2/RAMP 蛋白 by 应用范围

Find CDT2/RAMP 蛋白 validated for a specific application such as ELISA, SDS, WB, AbP. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular CDT2/RAMP 蛋白

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

CDT2/RAMP Protein (AA 1-730) (Strep Tag)

Reactivity Human

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3092255

Quantity 1 mg

Datasheet Datasheet

CDT2/RAMP Protein (AA 1-729) (Strep Tag)

Reactivity Mouse

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3134980

Quantity 1 mg

Datasheet Datasheet

CDT2/RAMP Protein (GST tag,His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN5505614

Quantity 50 μg

Datasheet Datasheet

Aliases for CDT2/RAMP 蛋白

denticleless E3 ubiquitin protein ligase homolog (DTL) 蛋白
denticleless E3 ubiquitin protein ligase (Dtl) 蛋白
denticleless E3 ubiquitin protein ligase homolog (Dtl) 蛋白
denticleless E3 ubiquitin protein ligase homolog S homeolog (dtl.S) 蛋白
denticleless E3 ubiquitin protein ligase homolog (Drosophila) (dtl) 蛋白
2810047L02Rik 蛋白
5730564G15Rik 蛋白
cb151 蛋白
CDT2 蛋白
cdt2 蛋白
cdt2-a 蛋白
chunp6871 蛋白
DCAF2 蛋白
dcaf2 蛋白
L2DTL 蛋白
l2dtl 蛋白
RAMP 蛋白
Ramp 蛋白
ramp 蛋白
RGD1310439 蛋白
wu:fb54b02 蛋白

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CDT2/RAMP 蛋白 by Grade

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CDT2/RAMP 蛋白 by Source

CDT2/RAMP 蛋白 by 蛋白类型

CDT2/RAMP 蛋白 by 应用范围

Popular CDT2/RAMP 蛋白

Aliases for CDT2/RAMP 蛋白

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