anti-Deleted in Azoospermia-Like (DAZL) 抗体

The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. 再加上,我们可以发DAZL 蛋白 (11)DAZL 试剂盒 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
DAZL 1618 Q92904
DAZL 680486  
DAZL 13164 Q64368
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antibodies-online.cn销售最多的anti-DAZL 抗体

Showing 10 out of 101 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-DAZL Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:12500  Positive Control:  721_B cell lysate 100 μL Log in to see 2至3个工作日
$289.00
详细
大鼠 山羊 非结合性 ELISA, WB ABIN185441 (0.1µg/ml) staining of human ovary lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. ABIN185441 (1µg/ml) staining of Rat Testes lysate (35µg protein in RIPA buffer). Detected by chemiluminescence. 100 μg Log in to see 6至7个工作日
$429.84
详细
Cow 非结合性 WB Host:  Rabbit  Target Name:  DAZL  Sample Type:  Stomach tumor lysates  Antibody Dilution:  1.0ug/ml Host:  Mouse  Target Name:  DAZL  Sample Tissue:  Mouse Brain  Antibody Dilution:  1ug/ml 100 μL Log in to see 2至3个工作日
$289.00
详细
山羊 非结合性 IHC (p), IHC, ELISA, WB ABIN250853 (0.1ug/ml) staining of Human Ovary lysate (35ug protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Immunohistochemistry-Paraffin: DAZL Antibody [ABIN250853] - Stainingof paraffin embedded Mouse Testis. 0.1 mg Log in to see 7至9个工作日
$488.73
详细
Cow 山羊 非结合性 EIA, IHC (p), WB   0.1 mg Log in to see 4至8个工作日
$462.00
详细
非结合性 WB WB Image DAZL antibody detects DAZL protein by western blot analysis. Whole cell extracts (30 μg) and Mouse tissue extracts (50 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with DAZL antibody , diluted at a dilution of 1:1000. 100 μL Log in to see 3至4个工作日
$466.18
详细
非结合性 ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: DAZL Antibody [NBP1-85306] - Staining of human cell line A-431 shows positivity in cytoplasm. Western Blot: DAZL Antibody [NBP1-85306] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY400541) 0.1 mL Log in to see 10至13个工作日
$494.38
详细
非结合性 WB 50 μg Log in to see 11至14个工作日
$551.83
详细
Cow 山羊 非结合性 ELISA, WB 100 μg Log in to see 11至14个工作日
$610.50
详细
非结合性 IHC, IHC (p), WB Immunohistochemistry-Paraffin: DAZL Antibody [NBP1-85307] - Staining of human testis shows distinct positivity in cells in seminiferus ducts. Western Blot: DAZL Antibody [NBP1-85307] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY400541) 0.1 mL Log in to see 10至13个工作日
$494.38
详细

引用最多的anti-DAZL 抗体

  1. Human Polyclonal DAZL Primary Antibody for IHC (p), IHC - ABIN250853 : Hermann, Sukhwani, Lin, Sheng, Tomko, Rodriguez, Shuttleworth, McFarland, Hobbs, Pandolfi, Schatten, Orwig: Characterization, cryopreservation, and ablation of spermatogonial stem cells in adult rhesus macaques. in Stem cells (Dayton, Ohio) 2007 (PubMed)
    Show all 9 Pubmed References

  2. Cynomolgus Monoclonal DAZL Primary Antibody for IF, IHC (p) - ABIN2473235 : Fabre, Bureau, Pouliquen, Lorans: Binding sites for human interleukin 1 alpha, gamma interferon and tumor necrosis factor on cultured fibroblasts of normal cornea and keratoconus. in Current eye research 1991 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal DAZL Primary Antibody for IF (p), IHC (p) - ABIN1385600 : Zhang, Zhao, Zhang, Hao, Yu, Min, Li, Ma, Chen, Yi, Tang, Meng, Liu, Wang, Shen, Zhang: Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable. in Chemosphere 2018 (PubMed)

  4. Dog (Canine) Polyclonal DAZL Primary Antibody for ELISA, WB - ABIN547486 : Cauffman, Van de Velde, Liebaers, Van Steirteghem: DAZL expression in human oocytes, preimplantation embryos and embryonic stem cells. in Molecular human reproduction 2005 (PubMed)

  5. Human Polyclonal DAZL Primary Antibody for ICC, IF - ABIN4304346 : Djureinovic, Fagerberg, Hallström, Danielsson, Lindskog, Uhlén, Pontén: The human testis-specific proteome defined by transcriptomics and antibody-based profiling. in Molecular human reproduction 2014 (PubMed)

更多抗DAZL的相互作用对抗体

Human Deleted in Azoospermia-Like (DAZL) interaction partners

  1. computational analysis of free energy change due to this point mutation using GROMOS96 indicated decreased stability of the DAZL protein. The N109T variant in an infertile male population may provide a genetic marker for mutational analysis of DAZL

  2. Data suggest that DAZL may be one such factor in human female fertility

  3. Through the translational regulation of novel RNA targets SMC1B and TEX11, DAZL may have a key role in regulating chromosome cohesion and DNA recombination; two processes fundamental in determining oocyte quality and whose establishment in foetal life may support lifelong fertility.

  4. hypermethylation of DAZL and BOULE promoters in human sperm is associated with human infertility

  5. data can be used to further elucidate the role of NANOS3 and DAZL in germ cell development both in vitro and in vivo

  6. DAZL was not expressed either in normal cultures or lesions from cervixes with papillomavirus infections and cervical intraepithelial neoplasia.

  7. analysis demonstrated that SNP260 of DAZL did not contribute to oligo/azoospermia while SNP386 was correlated to male infertility

  8. Neither the A260G nor the A386G polymorphism of DAZL appeared to be involved in male infertility.

  9. analysis of T12A and T54A polymorphisms role in the development of male infertility (Meta-Analysis)

  10. demonstrate that Boll is also transiently expressed during oogenesis in the fetal mouse ovary, but is simultaneously co-expressed within the same germ cells as Dazl

  11. Abnormal DNA methylation of the DAZL promoter might represent an epigenetic marker of male infertility.

  12. Amniotic fluid-derived stem cells (AFSc) seem to express Nodal, Nanog and DAZL and it speculated that the regulation of self-renewal in AFSc could be similar as in human embryonic stem cells.

  13. The A260G and A386G polymorphisms of the DAZL gene are not correlated with astheno-teratozoospermia-induced male infertility in the Han Chinese population.

  14. study identified the core promoter of the DAZL gene; also provided preliminary evidence for the role of a novel SNP of the DAZL gene promoter in spermatogenic failure

  15. overexpression of VASA and or DAZL, in both embryonic and induced pluripotent stem cells promoted differentiation into primordial germ cells, and maturation and progression through meiosis was enhanced.

  16. results showed no significant differences in the frequency of DAZL AG (P = 0.58) and MTHFR CT (P = 0.44) between oligozoospermic infertile men and controls

  17. These results suggest that incorrect epigenetic marks in germline gene DAZL may be correlated with male gametogenic defects.

  18. 386A-->G was significantly correlated with sperm count (P<0.0001) and motility (P<0.005) and 584+28c-->t was marginally correlated with sperm morphology.

  19. expression of spermatogenic phenotypes of partial AZFc deletions is independent of the variations in DAZL and BOULE in the Han population

  20. Dazl contributes to the differentiation of embryonic stem cells into germ cells.

Zebrafish Deleted in Azoospermia-Like (DAZL) interaction partners

  1. Cortical depth and differential transport of vegetally localized dorsal and germ line determinants, Wnt8a, grip2a, and Dazl, in the zebrafish embryo have been presented.

  2. that DAZL specifically binds the HuB 3'UTR and protects the message from degradation and/or enhances HuB translation, leading to the germ cell specific expression of HuB protein.

  3. DAZL relieves miRNA-mediated repression of germline mRNAs by controlling poly(A) tail length in zebrafish

  4. Data show that DAZ-like protein directly promotes the translation of the target mRNAs in vertebrates.

Cow (Bovine) Deleted in Azoospermia-Like (DAZL) interaction partners

  1. The methylation profile of DAZL gene promoter in bull spermatozoa in an attempt to speculate its role in cross-bred cattle subfertility was studied.

  2. analysis of genomic structure and transcript variants of the bovine DAZL gene

Xenopus laevis Deleted in Azoospermia-Like (DAZL) interaction partners

  1. The dynamic intracellular localization suggests that Dazl is a multifunctional protein regulating RNA metabolism required for Xenopus germline development

  2. Daz- and pumilio-like genes are asymmetrically localized in Pelophylax (Rana) oocytes and are expressed during early spermatogenesis.

  3. Dazl has the ability to stimulate translation and function at the level of translation initiation.

Mouse (Murine) Deleted in Azoospermia-Like (DAZL) interaction partners

  1. The 3'-UTR-dependent suppression of DAZL in mouse follicular oocytes is required for the progression of normal pre-implantation development.

  2. Down-regulated expression of Sox9 and Dazl may play important roles in MBP-induced testis injury.

  3. DAZL and CPEB1 regulate mRNA translation during oocyte maturation.

  4. findings demonstrate that DAZL associates with mRNA of Tet1, a catalyst of 5-hydroxylation of methyl-cytosine, and enhances Tet1 mRNA translation; DAZL enhances TET1-mediated cytosine hydroxymethylation in embryonic stem cells that are actively reprogramming to a pluripotent ground state

  5. Both yeast and mouse contain an RNA-binding protein, Rim4 and DAZL, respectively, that functions in translation and forms SDS-resistant aggregates during gametogenesis.

  6. Our findings strengthen the importance of RA and Dazl in the meiotic transition, provide important details about the Stra8 pathway, and open avenues to investigate early meiosis through analysis of Rec8 induction and function

  7. Data indicate that the germ cell-specific RNA binding protein DAZL limits both pluripotency and somatic differentiation in nascent primordial germ cells (PGCs).

  8. demonstrate that Boll is also transiently expressed during oogenesis in the fetal mouse ovary, but is simultaneously co-expressed within the same germ cells as Dazl

  9. Studies indicate that in Dazl-Knockout mice, cord/tubule-like structures, OSE invaginations and clusters of steroidogenic cells became increasingly prominent with age, but these abnormal structures remained benign.

  10. alternative splicing of exon8 of mDazl leads to the generation of the novel splice variant, Dazl-Delta8.

  11. DAZL was translocated to stress granules upon heat stress. Furthermore, stress granule assembly was significantly diminished in the early male germ cells of Dazl-knockout mice. DAZL induced the sequestration of signaling molecules such as RACK.

  12. structures suggest that the number of DAZL molecules bound to GUU triplets in the 3'-UTR provides a method for modulating the translation of a target RNA

  13. If DAZL expression is reduced, then follicles can grow to the late follicular stage despite declining levels of circulating FSH, leading to more follicles ovulating and increased litter size.

  14. Licensing of gametogenesis, dependent on RNA binding protein DAZL, as a gateway to sexual differentiation of fetal germ cells.

  15. CPEB1 regulates Dazl post-transcriptionally, and that DAZL is essential for meiotic maturation and embryonic cleavage

  16. Stra8 and Dazl are highly expressed in premeiotic germ cells that do not undergo further differentiation in aged mouse ovaries.

  17. Dazl contributes to the differentiation of embryonic stem cells into germ cells.

  18. Dazl is a master gene controlling germ cell differentiation and that ectopic expression of Dazl promotes the dynamic differentiation of mouse ES cells into gametes in vitro.

  19. Mouse DAZL protein can bind to 3'UTR of mTex19.1 mRNAs and may repress mTex19.1 expression at the translational level.Confirmed by both electrophoretic mobility shift assay and translation assay in Zebrafish embryo detecting the luciferase activity.

  20. Data show that EBs expressed Oct-4, OTR, OT, and DAZL.

Pig (Porcine) Deleted in Azoospermia-Like (DAZL) interaction partners

  1. cloning & characterization of the Deleted in AZoospermia Like (pDAZL) gene; pDAZL gene might be a good candidate gene of litter size trait & provides some marker information for marker-assisted selection.

  2. DNA methylation may suppress DAZL expression in somatic cells by interfering with Sp1 binding.

  3. The porcine DAZL coding sequence is highly homologous to those reported for the human and mouse cDNAs, and DAZL expression increases during oocyte maturation.

  4. MK is able to maintain a proliferative PGC phenotype mediated by the suppression of DAZL in early germ cells

  5. DAZL enhances in vitro derived porcine germ cell formation and meiosis.

  6. DAZL c.570+385 A>G and DAZL c.735+150 C>A locus were the potential molecular markers for improving the sperm quality traits in pigs.

DAZL 抗原简介

蛋白简介

The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DAZL

  • deleted in azoospermia like (DAZL) 抗体
  • deleted in azoospermia-like (DAZL) 抗体
  • deleted in azoospermia-like (dazl) 抗体
  • deleted in azoospermia-like (Dazl) 抗体
  • deleted in azoospermia-like L homeolog (dazl.L) 抗体
  • deleted in azoospermia like (dazl) 抗体
  • deleted in azoospermia like (Dazl) 抗体
  • Daz-like 抗体
  • Dazh 抗体
  • DAZL 抗体
  • dazl-a 抗体
  • dazl-B 抗体
  • Dazl1 抗体
  • Dazla 抗体
  • spgyla 抗体
  • Tpx-2 抗体
  • Tpx2 抗体
  • Xdazl 抗体

Protein level used designations for DAZL

DAZ homolog , DAZ-like autosomal , SPGY-like-autosomal , deleted in azoospermia-like 1 , germline specific RNA binding protein , spermatogenesis gene on the Y-like autosomal , deleted in azoospermia-like , DAZ-like protein , deleted in azoospermia-like protein , deleted in azoospermia protein 3 , xtdazl , DAZ-like protein A , DAZ-like protein B , Deleted in azoospermia-like-B , deleted in azoospermia-like-A , xDazl-A , xDazl-B , Deleted in azoospermia-like 1

GENE ID SPECIES
1618 Homo sapiens
460209 Pan troglodytes
695763 Macaca mulatta
58039 Danio rerio
477055 Canis lupus familiaris
530116 Bos taurus
680486 Rattus norvegicus
394676 Xenopus (Silurana) tropicalis
374054 Gallus gallus
398041 Xenopus laevis
13164 Mus musculus
100410648 Callithrix jacchus
100453294 Pongo abelii
100484743 Ailuropoda melanoleuca
100542379 Meleagris gallopavo
100556590 Anolis carolinensis
100579498 Nomascus leucogenys
100625706 Sus scrofa
100722319 Cavia porcellus
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