anti-Dedicator of Cytokinesis 8 (DOCK8) 抗体

DOCK8 encodes a member of the DOCK180 family of guanine nucleotide exchange factors. 再加上,我们可以发和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
DOCK8 81704 Q8NF50
DOCK8 76088 Q8C147
DOCK8 499337  
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Showing 10 out of 45 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
小鼠 非结合性 IF, WB 100 μL Log in to see 11至14个工作日
$507.83
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非结合性 ELISA, IHC (p), WB   0.1 mg Log in to see 2至3个工作日
$360.00
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小鼠 非结合性 IHC, IHC (p), WB   100 μL Log in to see 11至14个工作日
$507.83
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小鼠 非结合性 WB   100 μL Log in to see 11至14个工作日
$507.83
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小鼠 非结合性 IHC, IHC (p), WB   100 μL Log in to see 11至14个工作日
$507.83
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非结合性 WB Western blot analysis of extracts of THP-1 cells, using DOCK8 antibody (ABIN5972908). 100 μL Log in to see 11至16个工作日
$412.19
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非结合性 ELISA, WB   100 μg Log in to see 15至19个工作日
$527.03
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小鼠 非结合性 IHC, IHC (p)   100 μL Log in to see 11至14个工作日
$507.83
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小鼠 非结合性 IHC, WB Immunohistochemistry: dedicator of cytokinesis 8 Antibody (12D7) [NBP2-46470] - Analysis of Human liver tissue. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min) Western Blot: dedicator of cytokinesis 8 Antibody (12D7) [NBP2-46470] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY cytokinesis 8. 0.1 mL Log in to see 8至11个工作日
$516.98
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小鼠 非结合性 IHC Immunohistochemistry: dedicator of cytokinesis 8 Antibody (4F3) [NBP2-46469] - Analysis of Carcinoma of Human thyroid tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Immunohistochemistry: dedicator of cytokinesis 8 Antibody (4F3) [NBP2-46469] - Analysis of Human pancreas tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) 0.1 mL Log in to see 8至11个工作日
$516.98
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更多抗DOCK8的相互作用对抗体

Human Dedicator of Cytokinesis 8 (DOCK8) interaction partners

  1. Combined DOCK8 and CLEC7A mutations causing immunodeficiency in 3 brothers with diarrhea, eczema, and infections.

  2. a novel mechanism for Dock8 regulation of BCR signaling by regulating cd19 transcription

  3. EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction in CD4thorn T cells.

  4. A novel DOCK8 sequence insertion caused primary immunodeficiency in two siblings from a consanguineous family.

  5. DOCK8 deficiency may present severe immune dysregulation with features that may overlap with those of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and other IPEX-like disorders

  6. Recent advances in the understanding of DOCK8 function are summarized, paying particular attention to an emerging role as a signaling intermediate to promote immune responses to diverse external stimuli. [Review]

  7. In severe atopic eczema the dermatologist should initially suspect and document a mutation of DOCK8.

  8. Our results suggest that decreased expression of DOCK8 in response to CRH might disturb the immunosuppressive function of Tregs and contribute to stress-induced aggravation of AD symptoms.

  9. Sequence analysis identified two copies of missense mutation, c.4346C > T, in the coding region of the DOCK8 gene in a family with 3 patients with autosomal recessive Hyper-IgE syndrome.

  10. Our results showed that DOCK8-deficient patients have a profound defect in TH17 differentiation related to decreased STAT3 phosphorylation, translocation to the nucleus, and transcriptional activity

  11. The CD4+ T-cell compartment is greatly altered in the absence of DOCK8. Specifically, DOCK8-deficient patients have increased TH2 cells and defects in TH1 and TH17 cell differentiation

  12. comparative study provides a long-term observation of DOCK8- and STAT3-hyper-IgE syndrome patients with regard to clinical and laboratory findings, and assesses the activation and cytokine secretion of lymphocytes after in vitro stimulation

  13. mutations in Chinese patients with hyper-IgE syndrome

  14. Letter/Case Report: DOCK8 homozygous mutation leading to primary immune deficiency.

  15. DOCK8 deficiency is likely in patients with severe viral infections, allergies, and/or low IgM levels.

  16. CD147 has a role in promoting Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells

  17. DOCK8-regulated shape integrity of lymphocytes prevents cytothripsis and promotes antiviral immunity in the skin.

  18. Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells

  19. Mutations of DOCK8 in three children, two of whom developed sclerosing cholangitis, are reported.

  20. Hyper-IgE syndromes and atopic dermatitis patients showed different sensitization pattern of serum IgE corresponding to the allergic disease manifestations and Th-cell subset data, suggesting a key role of DOCK8 in the development of food allergy

Mouse (Murine) Dedicator of Cytokinesis 8 (DOCK8) interaction partners

  1. DOCK8 and WASp are in the same signaling pathway that links T-cell receptors (TCRs) to the actin cytoskeleton in TCR-driven actin assembly.

  2. LRCH1 as a novel effector to restrain PKCalpha-DOCK8-Cdc42 module-induced T cell migration and ameliorate experimental autoimmune encephalomyelitis (EAE).

  3. found that DOCK8 associated with LRAP35a, an adaptor molecule that binds to the Cdc42 effector myotonic dystrophy kinase-related Cdc42-binding kinase, and facilitated its activity to phosphorylate myosin II regulatory light chain

  4. DOCK8-deficient mice have poor control of primary cutaneous herpes simplex lesions and this is associated with increased virus loads. Furthermore, DOCK8-deficient mice showed a lack of CD4(+) T-cell infiltration into HSV-infected skin.

  5. DOCK8 expression in the haematopoietic compartment is required for protective immunity and its deficiency results in drastic reduction of RORgammat+ innate lymphoid cells in the GI tract

  6. conclude that DOCK8 is an important regulator of DC migration during an immune response and is prone to mutations that disrupt its crucial function

  7. DOCK8-regulated shape integrity of lymphocytes prevents cytothripsis and promotes antiviral immunity in the skin.

  8. DOCK8 is required for the development and survival of mature NKT cells.

  9. DOCK8 regulates interstitial DC migration by controlling Cdc42 activity spatially.

  10. Characterisation of the DOCK8-deficient mouse revealed T-cell lymphopenia, with increased T-cell turnover and decreased survival.

  11. These findings highlight a key role for DOCK8 in the survival and function of human and mouse CD8 T cells.

  12. Mutation of the DOCK8 protein in mice has profound effects on humoral immunity with a failure to sustain the antibody response and failure of germinal center B cell persistence. (Review)

  13. Humoral immunodeficiency due to Dock8 mutation provides evidence that organization of the immunological synapse is critical for signaling the survival of B cell subsets required for long-lasting immunity.

DOCK8 抗原简介

蛋白简介

This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with DOCK8

  • dedicator of cytokinesis 8 (dock8) 抗体
  • dedicator of cytokinesis 8 (DOCK8) 抗体
  • dedicator of cytokinesis 8 (Dock8) 抗体
  • 1200017A24Rik 抗体
  • 5830472H07Rik 抗体
  • A130095G14Rik 抗体
  • AI461977 抗体
  • im:7154406 抗体
  • MRD2 抗体
  • si:dkey-91m11.1 抗体
  • ZIR8 抗体

Protein level used designations for DOCK8

dedicator of cytokinesis 8 , dedicator of cytokinesis protein 8-like , 1200017A24Rik , dedicator of cytokinesis protein 8

GENE ID SPECIES
403040 Danio rerio
427348 Gallus gallus
473156 Pan troglodytes
476333 Canis lupus familiaris
100050677 Equus caballus
100225500 Taeniopygia guttata
100295817 Bos taurus
100354750 Oryctolagus cuniculus
100393468 Callithrix jacchus
100463658 Ailuropoda melanoleuca
100153522 Sus scrofa
100565160 Anolis carolinensis
81704 Homo sapiens
76088 Mus musculus
499337 Rattus norvegicus
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