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DACH2 is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. 再加上，我们可以发DACH2 蛋白 (3) 和 DACH2 试剂盒 (2)和数多这个蛋白质的别的产品。
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Mouse (Murine) Polyclonal DACH2 Primary Antibody for ELISA, WB - ABIN314279
Wu, Yang, Wang, Davoli, DAmico, Li, Cveklova, Kozmik, Lisanti, Russell, Cvekl, Pestell: DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. in The Journal of biological chemistry 2003
Human Polyclonal DACH2 Primary Antibody for IHC, IHC (p) - ABIN4304216
Nodin, Fridberg, Uhlén, Jirström: Discovery of dachshund 2 protein as a novel biomarker of poor prognosis in epithelial ovarian cancer. in Journal of ovarian research 2012
Dach2 and Hdac9 (显示 HDAC9 抗体) mediate the effects of muscle activity on muscle reinnervation; Myog (显示 MYOG 抗体) and Gdf5 (显示 GDF5 抗体) appear to stimulate muscle reinnervation through parallel pathways
Unlike Drosophila dachshund mutants that lack eyes and exhibit leg truncations, the eyes and limbs of Dach (显示 DACH1 抗体) double mutants are present, suggesting differences between Dach (显示 DACH1 抗体) and dachshund gene function during embryonic eye and limb formation.
a HDAC (显示 HDAC3 抗体)-Dach2-myogenin (显示 MYOG 抗体) signaling pathway has been identified to decode nerve activity and control muscle gene expression in developing and adult skeletal muscle
HDAC4 (显示 HDAC5 抗体) is a neural activity-regulated deacetylase and a key signaling component that relays neural activity to the muscle transcriptional machinery through Dach2, myogenin (显示 MYOG 抗体), and nAChR (显示 CHRNA4 抗体)
With Dach1 (显示 DACH1 抗体), may redundantly control female reproductive tract formation by regulating expression of target genes required for development of the Mullerian duct.
Exome sequencing in two brothers with distinct phenotype including congenital language disorder, growth retardation, intellectual disability and urinary and fecal incontinence, identifies missense mutations in ABCD1 (显示 ABCD1 抗体) and DACH2.
DACH2 is an independent prognostic marker that can be used at initial diagnosis of urothelial carcinoma of the bladder to identify patients who have a high potential to develop metastasis.
Most X;autosome translocations associated with premature ovarian failure do not interrupt X-linked genes. Only one of the six breakpoints disrupts a gene, DACH2.
This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure. Multiple transcript variants encoding different isoforms have been found for this gene.
dachshund homolog 2
, dachshund homolog 2 (Drosophila)
, dachshund homolog 2-like
, dachshund 2