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DHX58 抗体

(DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))
Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.
DHX58 抗体  (AA 479-678) DHX58 抗体  (AA 479-678) DHX58 抗体 (AA 479-678) (ABIN5542450)

DHX58 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 3E11F1 unconjugated

DHX58 抗体  (AA 479-678) DHX58 抗体  (AA 479-678) DHX58 抗体 (AA 479-678) (ABIN5542451)

DHX58 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 6A6A3 unconjugated

DHX58 抗体  (AA 389-678) DHX58 抗体  (AA 389-678) DHX58 抗体 (AA 389-678) (ABIN7164384)

DHX58 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

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Popular DHX58 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC, FACS, ICC
Validations
  • (4)
Cat. No. ABIN5542450
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, FACS, ICC
Validations
  • (4)
Cat. No. ABIN5542451
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN7164384
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN263162
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Rat
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7247327
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IP
Validations
  • (2)
Cat. No. ABIN949631
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF, ICC
Validations
  • (2)
Cat. No. ABIN6262957
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (2)
Cat. No. ABIN6139609
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN528898
Quantity 50 μg
Datasheet Datasheet
Reactivity Bat, Guinea Pig, Horse, Human, Monkey, Pig
Application WB
Validations
  • (1)
Cat. No. ABIN6742693
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN651621
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA
Validations
Cat. No. ABIN6390203
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IP
Validations
Cat. No. ABIN7113458
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA
Validations
Cat. No. ABIN6990807
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA
Validations
Cat. No. ABIN6990806
Quantity 0.1 mg
Datasheet Datasheet

Latest Publications for our DHX58 抗体

Szymura, Bernal, Wu, Zhang, Crawley, Voce, Campbell, Ranoa, Weichselbaum, Yamini: "DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy." in: BMC biology, Vol. 18, Issue 1, pp. 32, (2020) (PubMed).

Ranoa, Parekh, Pitroda, Huang, Darga, Wong, Huang, Andrade, Staley, Satoh, Akira, Weichselbaum, Khodarev: "Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs." in: Oncotarget, Vol. 7, Issue 18, pp. 26496-515, (2018) (PubMed).

Sanchez David, Combredet, Sismeiro, Dillies, Jagla, Coppée, Mura, Guerbois Galla, Despres, Tangy, Komarova: "Comparative analysis of viral RNA signatures on different RIG-I-like receptors." in: eLife, Vol. 5, pp. e11275, (2016) (PubMed).

Saito, Hirai, Loo, Owen, Johnson, Sinha, Akira, Fujita, Gale: "Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 2, pp. 582-7, (2007) (PubMed).

Akira, Uematsu, Takeuchi: "Pathogen recognition and innate immunity." in: Cell, Vol. 124, Issue 4, pp. 783-801, (2006) (PubMed).

Andrejeva, Childs, Young, Carlos, Stock, Goodbourn, Randall: "The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 49, pp. 17264-9, (2004) (PubMed).

Iwasaki, Medzhitov: "Toll-like receptor control of the adaptive immune responses." in: Nature immunology, Vol. 5, Issue 10, pp. 987-95, (2004) (PubMed).

Aliases for DHX58 抗体

DEXH-box helicase 58 L homeolog (dhx58.L) 抗体
DExH-box helicase 58 (DHX58) 抗体
DExH-box helicase 58 (dhx58) 抗体
probable ATP-dependent RNA helicase DHX58 (LOC100566102) 抗体
DEXH (Asp-Glu-X-His) box polypeptide 58 (dhx58) 抗体
DEXH (Asp-Glu-X-His) box polypeptide 58 (Dhx58) 抗体
DEXH-box helicase 58 (Dhx58) 抗体
B430001I08Rik 抗体
D11LGP2 抗体
D11lgp2e 抗体
D11Lgp2e 抗体
DHX58 抗体
lgp2 抗体
LGP2 抗体
Lgp2 抗体
LPG2 抗体
MGC82787 抗体
RGD1310093 抗体
RLR-3 抗体
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