D-2-Hydroxyglutarate Dehydrogenase 蛋白 (D2HGDH)

D2HGDH encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. 再加上,我们可以发D2HGDH 抗体 (24)D2HGDH 试剂盒 (7)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
D2HGDH 98314 Q8CIM3
D2HGDH 301624  
D2HGDH 728294 Q8N465
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
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大肠杆菌(E. Coli) REACT_Acidaminococcus fermentans 非结合性   50 μg Log in to see 2至3个工作日
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
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酵母菌 斑马鱼 His tag   500 μg Log in to see 60至71个工作日
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酵母菌 大鼠 His tag   1 mg Log in to see 60至71个工作日
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大肠杆菌(E. Coli) S tag,His tag 100 μg Log in to see 15至18个工作日
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D2HGDH 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine)

Rat (Rattus)

Human , ,
, ,

更多D-2-Hydroxyglutarate Dehydrogenase (D2HGDH)互动伙伴

Human D-2-Hydroxyglutarate Dehydrogenase (D2HGDH) interaction partners

  1. D2HGDH-GAL3ST2 (显示 GAL3ST2 蛋白) is more frequently seen in prostate cancer samples, and seems to be enriched in African Americans.

  2. D2HGDH elevates alpha-KG levels via IDH2 (显示 IDH2 蛋白) expression modulation, influencing histone and DNA methylation (显示 HELLS 蛋白), and HIF1alpha (显示 HIF1A 蛋白) hydroxylation. D2HGDH mutants found in diffuse large B-cell lymphoma are enzymatically inert.

  3. D2HGDH mutation is not associated with glioblastoma.

  4. We did not find evidence for mutations in the genes D2HGDH and L2HGDH (显示 L2HGDH 蛋白) as an alternative mechanism for raised 2-hydroxyglutarate levels in brain tumours

  5. Two novel pathogenic mutations in D-2-hydroxyglutarate dehydrogenase gene in patient with a mild presentation and asymptomatic siblings with D-2-hydroxyglutaric aciduria with a splice error (IVS4-2A-->G) and a missense mutation (c.1315A-->G;p.Asn439Asp).

  6. This enzyme assay will have utility in differentiating patients with 2-hydroxyglutaric aciduria and in assessing the residual activities linked to pathogenic mutations in the D2HGDH gene

蛋白简介D2HGDH

蛋白简介

This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features.

Gene names and symbols associated with D2HGDH

  • D-2-hydroxyglutarate dehydrogenase (D2hgdh)
  • D-2-hydroxyglutarate dehydrogenase (D2HGDH)
  • D-2-hydroxyglutarate dehydrogenase (d2hgdh)
  • AA408776 蛋白
  • AA408778 蛋白
  • AI325464 蛋白
  • D2HGD 蛋白
  • RGD1307976 蛋白
  • zgc:158661 蛋白

Protein level used designations for D2HGDH

D-2-hydroxyglutarate dehydrogenase, mitochondrial

GENE ID SPECIES
98314 Mus musculus
301624 Rattus norvegicus
728294 Homo sapiens
533003 Bos taurus
565889 Danio rerio
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