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CORT encodes a neuropeptide that is structurally similar to somatostatin. 再加上，我们可以发CST 试剂盒 (34) 和 CST 蛋白 (4)和数多这个蛋白质的别的产品。
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Human Polyclonal CST Primary Antibody for WB - ABIN611194
Greene, Bahn, Masson, Rabbitts: The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH 3T3 cells but represses its expression in mouse spleen development. in Molecular and cellular biology 1998
Show all 2 Pubmed References
Human Polyclonal CST Primary Antibody for WB - ABIN929265
DeVries, Holbrook, Winters, Jawor: Non-breeding gonadal testosterone production of male and female northern cardinals (Cardinalis cardinalis) following GnRH challenge. in General and comparative endocrinology 2011
Patients with newly diagnosed type 2 diabetes mellitus had lower plasma levels of vortistatin (CST) than healthy controls, and plasma CST was associated with glucose metabolism and insulin resistance.
There is a relationship between plamsa CST and BCKDK in sepsis patients.
Cortistatin emerges as a natural endogenous regulator of smooth muscle cells under pathological conditions and an attractive candidate for the pharmacological management of vascular diseases that course with neointimal lesion formation.
Identifies post-translational cleavage products of the homologous rat protein.
The cortistatin expression in the temporal lobe of Alzheimer's disease patients is decressed.
Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans.
first extensive study demonstrating that lymphoid tissues and immune cells express different levels of CST mRNA and that its expression can be regulated; hypothesize a role as an endogenous ligand of at least the sst2 receptor in the immune system
study demonstrates for the first time a selective and inducible expression of the recently discovered cortistatin, as well as somatostatin receptor 2, in human monocyte-derived cells
cortistatin-14 shown to be a high affinity ligand for G protein coupled receptor MrgX2 which is expressed in dorsal root ganglion
Cortistatin plays a role in the auto/paracrine regulation of the endocrine pancreas
Intravitreous somatostatin-like immunoreactivity deficit occurs in ptients with proliferative diabetic retinopathy.
Human immune cells produce CST, whereas macrophage lineage and activated endothelium express sst2, and human lymphocytes express sst3. The human thymus expresses sst1, 2, 3, MrgX2 and almost all immune cells express GHS-R. [review]
A lower expression of CST exists in diabetic retinas and it is associated with retinal neurodegeneration.
Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice.
Endogenous SST and CORT distinctly impact on DMBA-induced mammary gland tumorigenesis , in a manner that is strongly dependent on the metabolic/endocrine milieu (lean vs. obese status).
This study demonistrated that Cortistatin attenuates inflammatory pain via spinal and peripheral actions.
endogenous CORT is essential for the obesity-induced changes in insulin expression/secretion observed in mice
the role of endogenous CST is different from SST; CST exerted an unexpected stimulatory role on prolactin secretion
Regulation of cortistatin-expressing interneurons by activity-dependent BDNF expression may contribute to regulation of sleep behavior.
Cortistatin mRNA concentration in the hippocampus and dentate gyrus is significantly increased in aged non-transgenic (Tg) mice compared with young non-Tg mice.
GHRL, LEP, ADIP, INS and CORT concentrations were measured using radioimmunoassay
This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739.
, cortistatin preproprotein-like