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CNKSR1 is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target.
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CNKSR1 expression is increased in pancreatic cancer specimens and was found to be an independent prognostic marker of overall survival.
Data indicate connector enhancer of kinase suppressor of Ras 1 protein (CNK1) as a molecular platform that controls c-raf (显示 RAF1 蛋白) protein (RAF (显示 RAF1 蛋白)) and c-akt (显示 AKT1 蛋白) protein (AKT (显示 AKT1 蛋白)) signalling and determines cell fate decisions in a cell type- and cell stage-dependent manner.
The findings reveal SAM (显示 TTN 蛋白) domain-dependent oligomerization by AKT (显示 AKT1 蛋白) as a switch for CNK1 activation.
tyrosine phosphorylation is an important mechanism to control the subcellular localization of CNK1 and its distinct biological functions.
CNK1 mediates ephrinB1 (显示 EFNB1 蛋白) signaling that promotes cell migration through RhoA (显示 RHOA 蛋白) and JNK (显示 MAPK8 蛋白) activity.
Studies indicate that CNK1-driven proliferation relies on Akt (显示 AKT1 蛋白)-dependent phosphorylation and inactivation of FoxO (显示 FOXO3 蛋白) proteins.
These findings identify CNK1 as a new positive regulator of insulin (显示 INS 蛋白) signaling.
Thus, CNK1 is an essential mediator of an oncogenic pathway involved in invasion of breast and cervical cancer cells and is therefore a putative target for cancer therapy.
CNK1 promotes oncogenic signalling through Akt (显示 AKT1 蛋白) in breast cancer cell lines and tumours.
hCNK1 associates with Rhophilin (显示 RHPN1 蛋白) and RalGDS (显示 RALGDS 蛋白), Rho and Ras effector molecules, respectively, suggesting that it acts as a scaffold protein (显示 HOMER1 蛋白) to mediate cross talk between the two pathways
This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.
connector enhancer of kinase suppressor of ras 1
, connector enhancer of kinase suppressor of Ras 1
, connector enhancer of kinase suppressor of ras 1-like
, CNK homolog protein 1
, connector enhancer of KSR 1