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COL10A1 encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification.
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Results indicate that Cox-2 promotes Col10a1 expression and chondrocyte hypertrophy in vitro.
In a model of instability-induced osteoarthritis, Col (显示 HDAC1 蛋白) X was overexpressed in articular chondrocytes and osteophyte-forming cells in LOX-1 (显示 OLR1 蛋白)(+)/(+) mice and was significantly downregulated in articular chondrocytes and osteophyte-forming cells in LOX-1 (显示 OLR1 蛋白)(-)/(-) mice.
Col10 expression was seen in the hypertrophic zone at and below the tidemark of the mandibular condyle cartilage.
These data support a Cox-2-containing, Runx2 (显示 RUNX2 蛋白)-centered Col10a1 regulatory mechanism, during chondrocyte hypertrophic differentiation.
Data indicate Indian hedgehog (Ihh (显示 IHH 蛋白)) induces collagen type X COL10A1 expression and promotes its transcription through Runx2 (显示 RUNX2 蛋白)/Smad1 (显示 SMAD1 蛋白) interactions on a specific promoter region.
these results show that increased Col10a1 expression in Phex (显示 PHEX 蛋白)-deficient osteoblasts is not a major cause of the XLHR phenotype, which was an important issue to address based on the previous findings
Downregulation of carbonic anhydrase IX (显示 CA9 蛋白) promotes Col10a1 expression in chondrocytes.
Runx2 (显示 RUNX2 蛋白) directly interacts with murine Col10a1 cis (显示 CISH 蛋白)-enhancer.
SOX9 (显示 SOX9 蛋白) directly represses Col10a1 expression in immature/proliferating chondrocytes of the growth plate
Studies indicate that Col10a1 is highly expressed in hypertrophic chondrocytes and commonly used as a gene marker for this cell population.
increased expression of stromal colXalpha1 and low TILs correlate with poor pathologic response in ER+/HER2 (显示 ERBB2 蛋白)+ breast tumors. Further studies are needed to confirm their predictive value and impact on long-term outcomes, and to determine whether this collagen exerts a protective effect on the cancer cells or simply reflects other factors within the tumor microenvironment
a novel sequence variation involving an unusual mutational site of the COL10A1 gene can cause mild metaphyseal chondrodysplasia (显示 COL11A1 蛋白)
COL10A1 mutation 2005delC in a Chinese pedigree with Schmid type metaphyseal chondrodysplasia (显示 COL11A1 蛋白) is close to the C-terminus of the protein sequence and may result in genetic heterogeneity of the Chinese population
The results show that COL10A1 is a tumor biomarker upregulated in a wide variety of tumors including those of the breast, colon, bladder, stomach, esophagus, lung, testis, ovary and pancreas.
Yiqi Huayu Bushen Recipe increased the expression of aggrecan (显示 ACAN 蛋白), decreased the expression of type X collagen, and promoted cell proliferation in cells from degenerated human intervertebral discs.
Genetic variation near FRK (显示 FRK 蛋白)/COL10A1 and VEGFA (显示 VEGFA 蛋白) are associated with advanced age-related macular degeneration.
MCDS is a rare genetic skeletal disorder caused by a collagen type X defect. Though much is known about the molecular pathology of the causative COL10A1 mutations, causal therapy of the disease is not yet available
a frameshift mutation leading to elongation of the deduced alpha1(X) chain associated with Metaphyseal Chondrodysplasia (显示 COL11A1 蛋白) type Schmid
The effect of parathyroid hormone on expression of COL10 and COL2 in mesenchymal stem cells from osteoarthritic patients and analyzed the potential mechanisms related to its effect, was investigated.
These results indicate that nitrogen-rich plasma polymerized surfaces inhibit COL10A1 expression via the suppression of COX-1.
The 4.6 kb promoter is able to drive specific expression of Col10a1 in hypertrophic cartilage.
TSG is an important modulator of BMP-regulated induced collagen II and X expression and cartilage development and chondrocyte differentiation
This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD).
collagen alpha-1(X) chain
, procollagen, type X, alpha 1
, Schmid metaphyseal chondrodysplasia
, collagen X, alpha-1 polypeptide
, collagen, type X, alpha 1 (Schmid metaphyseal chondrodysplasia)
, collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia)
, type X collagen alpha 1
, LOW QUALITY PROTEIN: collagen alpha-1(X) chain
, collagen, type X, alpha 1