Collagen, Type X, alpha 1 蛋白 (COL10A1)

COL10A1 encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. 再加上,我们可以发Collagen, Type X, alpha 1 抗体 (29)Collagen, Type X, alpha 1 试剂盒 (18)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
COL10A1 12813 Q05306
COL10A1 1300 Q03692
大鼠 COL10A1 COL10A1 25681  
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COL10A1 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine)

Human

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Mouse (Murine) Collagen, Type X, alpha 1 (COL10A1) interaction partners

  1. Metaphyseal chondrodysplasia Schmid type disease severity in mice is increased by ATF6alpha ablation and decreased by ATF6beta ablation triggered by mutations in collagen X.

  2. Results indicate that Cox-2 promotes Col10a1 expression and chondrocyte hypertrophy in vitro.

  3. In a model of instability-induced osteoarthritis, Col X was overexpressed in articular chondrocytes and osteophyte-forming cells in LOX-1(+)/(+) mice and was significantly downregulated in articular chondrocytes and osteophyte-forming cells in LOX-1(-)/(-) mice.

  4. Col10 expression was seen in the hypertrophic zone at and below the tidemark of the mandibular condyle cartilage.

  5. These data support a Cox-2-containing, Runx2-centered Col10a1 regulatory mechanism, during chondrocyte hypertrophic differentiation.

  6. Data indicate Indian hedgehog (Ihh) induces collagen type X COL10A1 expression and promotes its transcription through Runx2/Smad1 interactions on a specific promoter region.

  7. these results show that increased Col10a1 expression in Phex-deficient osteoblasts is not a major cause of the XLHR phenotype, which was an important issue to address based on the previous findings

  8. Downregulation of carbonic anhydrase IX promotes Col10a1 expression in chondrocytes.

  9. Annexins and collagen X may rather fulfill functions in growth plate cartilage not directly linked to the mineralization process.

  10. Runx2 directly interacts with murine Col10a1 cis-enhancer.

  11. SOX9 directly represses Col10a1 expression in immature/proliferating chondrocytes of the growth plate

  12. Studies indicate that Col10a1 is highly expressed in hypertrophic chondrocytes and commonly used as a gene marker for this cell population.

  13. cartilaginous regeneration is due to the expression of chondrogenic factors, such as Sox 9 and type II and X collagens

  14. endochondral ossification-specific collagen X contributes to the establishment of a hematopoietic niche at the chondro-osseous junction

  15. we have uncovered a novel molecular mechanism linking GADD45beta via the MTK1/MKK3/6/p38 axis to C/EBPbeta-TAD4 activation of Col10a1 transcription in terminally differentiating chondrocytes

  16. demonstration of sleketal defects and altered marrow and hematopoiesis in all Tg mice with dominant interference mutations for collagen X

  17. These data suggest that alpha1(X) collagen (Col10a1) is a direct transcriptional target of Runx2 during chondrogenesis.

  18. The 4.6 kb promoter is able to drive specific expression of Col10a1 in hypertrophic cartilage.

  19. the triple-helical region of collagen X contains a specific DDR2 binding site that is capable of receptor activation

  20. TSG is an important modulator of BMP-regulated induced collagen II and X expression and cartilage development and chondrocyte differentiation

Human Collagen, Type X, alpha 1 (COL10A1) interaction partners

  1. Plasma samples from lung cancer patients and healthy heavy-smokers controls were tested for levels of COL11A1 and COL10A1 (n = 57 each) and SPARC (n = 90 each). Higher plasma levels of COL10A1 were detected in patients (p

  2. All affected individuals are heterozygous for the missense mutation collagen type X alpha 1 chain (COL10A1) rs111033552.

  3. increased expression of stromal colXalpha1 and low TILs correlate with poor pathologic response in ER+/HER2+ breast tumors. Further studies are needed to confirm their predictive value and impact on long-term outcomes, and to determine whether this collagen exerts a protective effect on the cancer cells or simply reflects other factors within the tumor microenvironment

  4. a novel sequence variation involving an unusual mutational site of the COL10A1 gene can cause mild metaphyseal chondrodysplasia

  5. COL10A1 mutation 2005delC in a Chinese pedigree with Schmid type metaphyseal chondrodysplasia is close to the C-terminus of the protein sequence and may result in genetic heterogeneity of the Chinese population

  6. Concentration of serum collagen type X levels correlated with cartilage degradation in osteoarthritis patients.

  7. The results show that COL10A1 is a tumor biomarker upregulated in a wide variety of tumors including those of the breast, colon, bladder, stomach, esophagus, lung, testis, ovary and pancreas.

  8. Yiqi Huayu Bushen Recipe increased the expression of aggrecan, decreased the expression of type X collagen, and promoted cell proliferation in cells from degenerated human intervertebral discs.

  9. Genetic variation near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.

  10. MCDS is a rare genetic skeletal disorder caused by a collagen type X defect. Though much is known about the molecular pathology of the causative COL10A1 mutations, causal therapy of the disease is not yet available

  11. a frameshift mutation leading to elongation of the deduced alpha1(X) chain associated with Metaphyseal Chondrodysplasia type Schmid

  12. The effect of parathyroid hormone on expression of COL10 and COL2 in mesenchymal stem cells from osteoarthritic patients and analyzed the potential mechanisms related to its effect, was investigated.

  13. These results indicate that nitrogen-rich plasma polymerized surfaces inhibit COL10A1 expression via the suppression of COX-1.

  14. speculate that complete loss of mutant transcripts yields COL10A1 haploinsufficiency and late clinical presentation while incomplete loss of mutant transcripts yields dominant-negative effects with early clinical presentation

  15. The total expression of type X collagen in the concave side growth plates of the lower end vertebrae was higher than that in the same side growth plates of apex.

  16. methylation-based COL10A1 gene silencing is established in cartilage tissue and human articular chondrocytes during chondrogenesis.

  17. chains harboring Schmid metaphyseal chondrodysplasia NC1 domain mutations are selectively retained and degraded in stably transfected cells

  18. The crystal structure at 2.0 A resolution of the human collagen X NC1 domain reveals an intimate trimeric assembly strengthened by a buried cluster of calcium ions.

  19. The 4.6 kb promoter is able to drive specific expression of Col10a1 in hypertrophic cartilage.

  20. exposure of the NC1 thiol may trigger the recognition and degradation of mutant collagen X chains

Cow (Bovine) Collagen, Type X, alpha 1 (COL10A1) interaction partners

  1. The 4.6 kb promoter is able to drive specific expression of Col10a1 in hypertrophic cartilage.

  2. TSG is an important modulator of BMP-regulated induced collagen II and X expression and cartilage development and chondrocyte differentiation

蛋白简介Collagen, Type X, alpha 1 (COL10A1)

蛋白简介

This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD).

Gene names and symbols associated with COL10A1

  • collagen, type X, alpha 1 (Col10a1)
  • collagen type X alpha 1 chain (COL10A1)
  • collagen, type X, alpha 1 (COL10A1)
  • collagen type X alpha 1 chain (Col10a1)
  • Col10 蛋白
  • Col10a-1 蛋白

Protein level used designations for COL10A1

collagen alpha-1(X) chain , procollagen, type X, alpha 1 , Schmid metaphyseal chondrodysplasia , collagen X, alpha-1 polypeptide , collagen, type X, alpha 1 (Schmid metaphyseal chondrodysplasia) , collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia) , type X collagen alpha 1 , LOW QUALITY PROTEIN: collagen alpha-1(X) chain , collagen, type X, alpha 1

GENE ID SPECIES
12813 Mus musculus
1300 Homo sapiens
282416 Bos taurus
100858979 Gallus gallus
25681 Rattus norvegicus
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