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CPSF3 encodes a member of the metallo-beta-lactamase family.
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Human Polyclonal CPSF3 Primary Antibody for WB - ABIN526863
Johansson, Somberg, Li, Backström Winquist, Fay, Ryan, Pim, Banks, Schwartz: HPV-16 E2 contributes to induction of HPV-16 late gene expression by inhibiting early polyadenylation. in The EMBO journal 2012
the molecular mechanism that recruits the CPSF73 endonuclease to histone pre-mRNAs
The data support a model where Star-PAP (显示 TUT1 抗体) binds to the pre-mRNA, recruits the CPSF complex to the 3'-end of pre-mRNA and then defines cleavage by CPSF 73 and subsequent polyadenylation of its target mRNAs.
up-regulated by HIV-1 TAT (显示 TAT 抗体) protein; this could represent a novel mechanism by which HIV increases mRNA processing, causing an increase in both cell and viral gene expression.
crystal structures of human CPSF-73 at 2.1 A resolution, complexed with zinc ions and a sulphate that might mimic the phosphate group of the substrate; CPSF-73 is the pre-mRNA 3'-end-processing endonuclease
this study identifies CPSF-73 as an important regulatory protein that represses the basal transcriptional activity of the HIV-1 LTR promoter
Conserved residues in CPSF-73 and CPSF2 (显示 CPSF2 抗体) are required for assembly of the endonuclease activity that cleaves histone pre-mRNAs.
CSR1 (显示 SCARA3 抗体) appears to induce cell death through a novel mechanism by hijacking a critical RNA processing enzyme CPSF3.
Degradation of the downstream cleavage product (DCP (显示 ACE 抗体)) does not depend on the Xrn2 (显示 XRN2 抗体) 5' exonuclease (显示 EXO1 抗体), suggesting that CPSF-73 degrades the DCP (显示 ACE 抗体) both in vitro and in vivo.
The tumor suppressor Cdc73 (显示 CDC73 抗体) functionally associates with CPSF and CstF 3 (显示 CSTF3 抗体)' mRNA processing factors.
This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing.
cleavage and polyadenylation specificity factor 73 kDa subunit
, cleavage and polyadenylation specificity factor subunit 3
, cleavage and polyadenylation specificity factor 3
, cleavage and polyadenylation specific factor 3, 73kDa
, cleavage and polyadenylation specificity factor subunit 3-like
, mRNA 3'-end-processing endonuclease CPSF-73
, CPSF 73 kDa subunit