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CPSF3 encodes a member of the metallo-beta-lactamase family. 再加上，我们可以发CPSF3 蛋白 (5)和数多这个蛋白质的别的产品。
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Human Polyclonal CPSF3 Primary Antibody for WB - ABIN526863
Johansson, Somberg, Li, Backström Winquist, Fay, Ryan, Pim, Banks, Schwartz: HPV-16 E2 contributes to induction of HPV-16 late gene expression by inhibiting early polyadenylation. in The EMBO journal 2012
the molecular mechanism that recruits the CPSF73 endonuclease to histone pre-mRNAs
The data support a model where Star-PAP binds to the pre-mRNA, recruits the CPSF complex to the 3'-end of pre-mRNA and then defines cleavage by CPSF 73 and subsequent polyadenylation of its target mRNAs.
up-regulated by HIV-1 TAT protein; this could represent a novel mechanism by which HIV increases mRNA processing, causing an increase in both cell and viral gene expression.
crystal structures of human CPSF-73 at 2.1 A resolution, complexed with zinc ions and a sulphate that might mimic the phosphate group of the substrate; CPSF-73 is the pre-mRNA 3'-end-processing endonuclease
this study identifies CPSF-73 as an important regulatory protein that represses the basal transcriptional activity of the HIV-1 LTR promoter
Conserved residues in CPSF-73 and CPSF2 are required for assembly of the endonuclease activity that cleaves histone pre-mRNAs.
CSR1 appears to induce cell death through a novel mechanism by hijacking a critical RNA processing enzyme CPSF3.
Degradation of the downstream cleavage product (DCP) does not depend on the Xrn2 5' exonuclease, suggesting that CPSF-73 degrades the DCP both in vitro and in vivo.
The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors.
This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing.
cleavage and polyadenylation specificity factor 73 kDa subunit
, cleavage and polyadenylation specificity factor subunit 3
, cleavage and polyadenylation specificity factor 3
, cleavage and polyadenylation specific factor 3, 73kDa
, cleavage and polyadenylation specificity factor subunit 3-like
, mRNA 3'-end-processing endonuclease CPSF-73
, CPSF 73 kDa subunit