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May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. 再加上，我们可以发Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kDa, tau Variant 蛋白 (4) 和 和数多这个蛋白质的别的产品。
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Cstf2t Polyadenylation Gene Plays a Sex-Specific Role in Learning Behaviors in Mice
This demonstrates that tauCstF-64 is an important stage-specific regulator of Crem (显示 CREM 抗体) mRNA processing that modulates the spatial and temporal expression of downstream stage-specific genes necessary for the proper development of sperm in mice.
The results suggest that tauCstF-64 plays a role in 3' end determination and transcription termination for a large range of germ cell-expressed genes.
tauCstF-64 is required not only for expression of genes involved in morphological differentiation of spermatids but also for genes having products that function during interaction of motile spermatozoa with eggs.
physiologically increased levels of CstF-64 (显示 CSTF2 抗体) observed in LPS (显示 TLR4 抗体)-stimulated RAW macrophages contribute to the changes in expression and alternative polyadenylation of a number of genes
These results suggest the hypothesis that tauCstF-64 mRNA is regulated at the translational or post-translational level.
tauCstF-64 promotes germ-cell-specific patterns of polyadenylation by binding to different downstream sequence elements.
Targeted disruption of Cstf2t in mice causes aberrant spermatogenesis, specifically disrupting meiotic and postmeiotic development, resulting in male infertility resembling oligoasthenoteratozoospermia.
The Cstf2t protein contributes to proteomic diversity by regulating alternative polyadenylation of neural mRNAs.
Studied expression levels of CstF-64 (显示 CSTF2 抗体) in EV71-infected cells; showed reduction of CstF-64 (显示 CSTF2 抗体) during virus infection correlated with production of viral 3C(pro). CstF-64 (显示 CSTF2 抗体) was cleaved in vitro by 3C(pro) not by mutant 3C(pro) variants.
Radiation hybrid mapping places the human tauCstF-64 gene at 10q22-q23, which is the site of a translocation that has been associated with human neurological problems and male infertility.
structure of the RNA-binding domain of CstF-64 (显示 CSTF2 抗体) containing an RNA recognition motif (RRM) augmented by N- and C-terminal helices
upstream element in human papillomavirus type 16 interacted specifically with CstF-64 (显示 CSTF2 抗体), hnRNP C1/C2 (显示 HNRNPC 抗体) & polypyrimidine tract binding protein (显示 PTBP1 抗体), suggesting these factors were enhancing or regulating polyadenylation at the HPV-16 early polyadenylation signal
May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs.
CF-1 64 kDa subunit tau
, CF-1 64 kDa subunit, tau
, CSTF 64 kDa subunit tau
, CSTF 64 kDa subunit, tau
, cleavage stimulation factor 64 kDa subunit tau
, cleavage stimulation factor 64 kDa subunit, tau
, cleavage stimulation factor subunit 2 tau
, cleavage stimulation factor subunit 2 tau variant
, cleavage stimulation factor, 3' pre-RNA subunit 2, 64 kDa, tau
, cleavage stimulation factor, 3' pre-RNA subunit 2, tau