Citrate Synthase 蛋白 (CS)

Human Citrate Synthase (CS) interaction partners

1. citrate synthase and ACSS1 (显示 ACSS1 蛋白) have tumorigenic functions in hepatocellular carcinoma

2. Citrate synthase activity was lower in patients with heart failure with preserved ejection fraction compared to controls.

3. mir (显示 MLXIP 蛋白)-122 and its targets G6PC3 (显示 G6PC3 蛋白), ALDOA (显示 ALDOA 蛋白) and CS play roles in the hypoxia responses that regulate glucose and energy metabolism and can serve as hypoxia biomarkers.

4. METTL12 (显示 METTL12 蛋白) methylates CS on Lys (显示 LYZ 蛋白)-395, which is localized in the CS active site. Interestingly, the METTL12 (显示 METTL12 蛋白)-mediated methylation inhibited CS activity and was blocked by the CS substrate oxaloacetate.

5. Data suggest that METTL12 (显示 METTL12 蛋白), localized in mitochondrial matrix, modifies/methylates Lys368 of citrate synthase in external surface region close to its catalytic site; addition/removal of methylation has no effect on citrate synthase activity; Lys368 occurs in highly conserved sequence of amino acid residues of citrate synthase. (METTL12 (显示 METTL12 蛋白) = methyltransferase-like protein 12)

6. Data suggest that downregulation of citrate synthase (CS) expression in 293T cells leads to low level of ATP production, excessive superoxide formation and cell apoptosis, which implies a possible mechanism for hearing loss in A/J mice.

7. Hence, we conclude that SIRT3 (显示 SIRT3 蛋白) exhibits neuroprotection via deacetylating and increasing mitochondrial enzyme activities.

8. The citrate synthase knockdown cells exhibited severe defects in respiratory activity and marked decreases in ATP production, but great increases in glycolytic metabolism.

9. Citrate synthase (CS) is a direct RORalpha target gene and one mechanism by which RORalpha regulates lipid metabolism is via regulation of CS expression.

10. It is likely that enhanced citrate synthase activity contributes to the conversion of glucose to lipids in pancreatic cancer providing substrate for membrane lipids synthesis.

Pig (Porcine) Citrate Synthase (CS) interaction partners

Mouse (Murine) Citrate Synthase (CS) interaction partners

1. The CS activity decreased in the infarcted tissue of wild-type (WT) mice at day 1 post-MI (p<0.05), but this was not observed in the MMP-9 (显示 MMP9 蛋白) null mice, suggesting that MMP-9 (显示 MMP9 蛋白) deletion helps to maintain the mitochondrial activity post-MI

2. Multiple lines of evidence implicate this missense mutation (H55N) as the underlying cause of ahl4-related hearing loss, likely through its effects on mitochondrial adenosine trisphosphate (ATP) and free radical production in cochlear hair cells.

Rabbit Citrate Synthase (CS) interaction partners

1. CS and SERCA (显示 ATP2A3 蛋白) activities were significantly higher in the pubococcygeus (Pc) compared with the ischiocavernosus/bulbospongiosus (Ic/Bs) pelvic floor muscles, whereas the ChAT activity of the Ic/Bs was higher than that of the Pc muscle.