Chromosome 11open Reading Frame 9 蛋白 (C11orf9)

Transcription regulator required for expression of CNS myelin genes such as Mbp and Mog, thereby playing a central role in oligodendrocyte maturation and central nervous system (CNS) myelination. 再加上,我们可以发Chromosome 11open Reading Frame 9 抗体 (21)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
C11orf9 745 Q9Y2G1
C11orf9 225908 Q3UR85
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C11orf9 蛋白 by Origin and Source

Origin 在表达 标记
Human
,
Mouse (Murine)
,

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Human Chromosome 11open Reading Frame 9 (C11orf9) interaction partners

  1. The relative scarcity of oligodendrocyte lineage cells expressing MYRF in demyelinated MS lesions demonstrates, for the first time, that chronic lesions lack oligodendrocytes that express this necessary transcription factor for remyelination and supports the notion that a failure to fully differentiate underlies remyelination failure.

  2. molecular mechanisms underlying the homo-trimerization of Myrf N-terminal fragments and the homo-trimeric DNA binding of Myrf N-terminal fragments

  3. A Bacteriophage tailspike domain promotes self-cleavage of a human membrane-bound transcription factor, the myelin regulatory factor MYRF.

Mouse (Murine) Chromosome 11open Reading Frame 9 (C11orf9) interaction partners

  1. Purification, crystallization and X-ray analysis of DNA-binding domain of MRF has been reported.

  2. molecular mechanisms underlying the homo-trimerization of Myrf N-terminal fragments and the homo-trimeric DNA binding of Myrf N-terminal fragments

  3. mutant huntingtin (显示 HTT 蛋白) binds abnormally to MYRF and affects its transcription activity

  4. Here we identify Myrf as an oligodendrocyte-specific target of Sox10 (显示 SOX10 蛋白) and map a Sox10 (显示 SOX10 蛋白) responsive enhancer to an evolutionarily conserved element in intron 1 of the Myrf gene

  5. Expression of MRF within the adult central nervous system (CNS) is critical to maintain oligodendrocyte identity and integrity of CNS myelin.

  6. NPC1 (显示 NPC1 蛋白) protein was expressed in oligodendrocytes and the amount of myelin protein was generally decreased in all parts of the brain and spinal cord in NPC1 (显示 NPC1 蛋白)-mutant mice

  7. Study identifies gene model 98, which we have named myelin gene regulatory factor (MRF), as a transcriptional regulator required for CNS myelination.

蛋白简介Chromosome 11open Reading Frame 9 (C11orf9)

蛋白简介

Transcription regulator required for expression of CNS myelin genes such as Mbp and Mog, thereby playing a central role in oligodendrocyte maturation and central nervous system (CNS) myelination. Probably acts as a transcription factor that directly binds DNA and activates expression of CNS myelin genes.

Gene names and symbols associated with C11orf9

  • chromosome 5 open reading frame, human C11orf9 (C5H11ORF9)
  • myelin regulatory factor L homeolog (myrf.L)
  • myelin regulatory factor (MYRF)
  • myelin regulatory factor (Myrf)
  • 6030439E18 蛋白
  • c11orf9 蛋白
  • Gm98 蛋白
  • Gm1804 蛋白
  • Mrf 蛋白
  • Ndt80 蛋白
  • pqn-47 蛋白

Protein level used designations for C11orf9

myelin gene regulatory factor

GENE ID SPECIES
422966 Gallus gallus
447583 Xenopus laevis
745 Homo sapiens
225908 Mus musculus
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