anti-Cholinergic Receptor, Nicotinic, alpha 5 (Neuronal) (CHRNA5) 抗体

The protein encoded by CHRNA5 is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. 再加上,我们可以发CHRNA5 蛋白 (6)CHRNA5 试剂盒 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
CHRNA5 1138 P30532
CHRNA5 25102  
CHRNA5 110835 Q2MKA5
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产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 IHC (p), WB Western blot analysis of CHRNA5 using anti-CHRNA5 antibody .   Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.    Lane 1: rat skeletal muscle tissue lysates,  Lane 2: HEPG2 whole cell lysates.   After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-CHRNA5 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for CHRNA5 at approximately 53KD. The expected band size for CHRNA5 is at 53KD. IHC analysis of CHRNA5 using anti-CHRNA5 antibody .  CHRNA5 was detected in paraffin-embedded section of mouse intestine tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-FBXL4 Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. 100 μg Log in to see 4至6个工作日
$280.00
详细
Cow 非结合性 WB WB Suggested Anti-CHRNA5 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Human Spleen 100 μL Log in to see 2至3个工作日
$289.00
详细
Cow 非结合性 WB WB Suggested Anti-CHRNA5 Antibody Titration:  1.0ug/ml  ELISA Titer:  1:12500  Positive Control:  Jurkat cell lysate 100 μL Log in to see 2至3个工作日
$229.00
详细
小鸡 非结合性 WB Western blot analysis of CHRNA5 expression in HeLa (A), Jurkat (B), mouse brain (C), rat brain (D) whole cell lysates. 200 μL Log in to see 13至14个工作日
$487.50
详细
非结合性 WB CHRNA5 Antibody (Center)  western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the CHRNA5 antibody detected the CHRNA5 protein (arrow). CHRNA5 Antibody (Center)  western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the CHRNA5 antibody detected the CHRNA5 protein (arrow). 400 μL Log in to see 10至11个工作日
$335.50
详细
山羊 非结合性 ELISA, WB 0.1 mg Log in to see 2至3个工作日
$481.25
详细
山羊 非结合性 ELISA, IHC, IHC (p), WB 50 μg Log in to see 11至14个工作日
$484.00
详细
Cow 非结合性 WB 100 μg Log in to see 7至9个工作日
$493.17
详细
Cow 非结合性 WB 50 μg Log in to see 7至9个工作日
$551.83
详细
小鼠 非结合性 ELISA, FACS, WB Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Western blot analysis using CHRNA5 mAb against human CHRNA5 (AA: 23-254) recombinant protein. (Expected MW is 52.5 kDa) 100 μg Log in to see 2至3个工作日
$430.10
详细

更多抗CHRNA5的相互作用对抗体

Human Cholinergic Receptor, Nicotinic, alpha 5 (Neuronal) (CHRNA5) interaction partners

  1. Frequency of the cholinergic receptor nicotinic alpha 5 (CHRNA5) rs16969968-A allele and cholinergic receptor nicotinic alpha 3 (CHRNA3) rs1051730-T allele were significantly higher in lung cancer than in normal controls.

  2. The rs13180 (IREB2 (显示 IREB2 抗体)), rs16969968 (CHRNA5) and rs1051730 (CHRNA3 (显示 CHRNA3 抗体)) were significantly associated with Chronic obstructive pulmonary disease (COPD (显示 ARCN1 抗体)) in additive model [Padj =0.00001, odds ratio (OR)=0.64; Padj =0.0001, OR=1.41 and Padj =0.0001, OR=1.47]. The C-G haplotype by rs13180 and rs1051730 was a protective factor for COPD (显示 ARCN1 抗体) in our population (Padj =0.0005, OR=0.61).

  3. Our present study suggested that rs667282 in CHRNA5-A3 may modify the prognosis of patients with advanced non-small cell lung cancer

  4. our results show that a genomic region with functionally related genes, such as the CHRNA5/CHRNA3/CHRNB4 cluster, is under coordinated regulatory control.

  5. The minor allele increased the risk of COPD (显示 ARCN1 抗体) when compared to the population at large. Homozygosity for the risk allele was associated in both cohorts with all-cause mortality, with any type of cancer among the COPD (显示 ARCN1 抗体) patients and with the number of pack-years among the male smokers.

  6. The data replicate previous result suggesting CHRNA5 as a candidate gene for chronic obstructive pulmonary disease (COPD (显示 ARCN1 抗体)) and rs8040868 as a risk variant for the development of COPD (显示 ARCN1 抗体) in the Swedish population.

  7. The results of this study suggests a pleiotropic role of Chr15q25 CHRNA5-CHRNA3-CHRNB4 gene cluster with complex influences in ADHD, tobacco smoking and cognitive performance.

  8. Polymorphisms in the CHRNA5 and NRXN1 (显示 NRXN1 抗体) genes, influenced greater consumption of cigarettes in a Mexican Mestizo population.

  9. RP11 (显示 PRPF31 抗体)-650L12.2 rs149941240 polymorphism was associated with the risk of colorectal cancer.

  10. We determined that the other patients harbored mutations in genes that have not previously been linked to RTT or other neurodevelopmental syndromes, such as the ankyrin repeat containing protein (显示 EHMT2 抗体) ANKRD31 or the neuronal acetylcholine receptor subunit alpha-5 (CHRNA5).

Mouse (Murine) Cholinergic Receptor, Nicotinic, alpha 5 (Neuronal) (CHRNA5) interaction partners

  1. The findings reveal a proaddiction adaptive response to chronic nicotine in which nitric oxide and SST (显示 SST 抗体) are released by a specific CHRNA5-expressing neuronal population to provide retrograde inhibition of the habenula- interpeduncular nucleus circuit and thereby enhance the motivational properties of nicotine.

  2. Genetic deletion of alpha5 nAChR (显示 CHRNA4 抗体) subunits leads to a behavioural phenotype that exactly matches that observed after antagonizing dopamine receptors.

  3. Chrna5 KO mice did not exhibit high responses to novelty but showed decreased novelty-induced rearing behaviour together with high anxiety. Exposure to high doses of nicotine rescued these phenotypes. Results suggest that altered alpha5*-nAChR (显示 CHRNA4 抗体) cholinergic signalling contributes to emotional/behavioural impairments that may be alleviated by nicotine consumption.

  4. These results highlight the involvement of the alpha5 nAChR (显示 CHRNA4 抗体) subunit in the development of hyperalgesia, allodynia and inflammation associated with chronic neuropathic and inflammatory pain models.

  5. Overexpression of the genomic cluster CHRNA5/A3/B4 in mice increases somatic signs associated with morphine withdrawal and Knockout of alpha5 gene reduced somatic signs in morphine-treated mice

  6. Data reveal a highly regulated temporal-spatial pattern of alpha5 nAChR (显示 CHRNA4 抗体) subunit expression during important periods of lung morphogenesis by FoxA2 (显示 FOXA2 抗体).

  7. increased nicotine intake in mice with a null mutation in Chrna5

  8. Polymorphisms located within the Chrna5-Chrna3-Chrnb4 cluster on mouse chromosome 9 were found to co-segregate with alcohol preference, with high-drinking F(2) mice carrying B6 alleles and low-drinking F(2) mice carrying D2 alleles.

CHRNA5 抗原简介

蛋白简介

The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).

Gene names and symbols associated with CHRNA5

  • cholinergic receptor, nicotinic, alpha 5 (chrna5) 抗体
  • cholinergic receptor nicotinic alpha 5 subunit (CHRNA5) 抗体
  • cholinergic receptor nicotinic alpha 5 subunit L homeolog (chrna5.L) 抗体
  • cholinergic receptor nicotinic alpha 5 subunit (Chrna5) 抗体
  • cholinergic receptor, nicotinic, alpha polypeptide 5 (Chrna5) 抗体
  • Acra-5 抗体
  • Acra5 抗体
  • LNCR2 抗体
  • zgc:110642 抗体

Protein level used designations for CHRNA5

neuronal acetylcholine receptor subunit alpha-5 , cholinergic receptor, nicotinic, alpha polypeptide 5 , Cholinergic receptor, neuronal nicotinic, alpha polypeptide-5 , acetylcholine receptor, nicotinic, alpha 5 (neuronal) , neuronal nicotinic acetylcholine receptor, alpha5 subunit , acetylcholine receptor alpha 5 , cholinergic receptor neuronal nicotinic alpha protein 5 , nicotinic acetylcholine receptor alpha5 subunit

GENE ID SPECIES
550584 Danio rerio
282177 Bos taurus
1138 Homo sapiens
446384 Xenopus laevis
386577 Gallus gallus
482112 Canis lupus familiaris
25102 Rattus norvegicus
619369 Pan troglodytes
110835 Mus musculus
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