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The protein encoded by CHRNA5 is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. 再加上，我们可以发CHRNA5 蛋白 (6) 和 CHRNA5 试剂盒 (5)和数多这个蛋白质的别的产品。
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Frequency of the cholinergic receptor nicotinic alpha 5 (CHRNA5) rs16969968-A allele and cholinergic receptor nicotinic alpha 3 (CHRNA3) rs1051730-T allele were significantly higher in lung cancer than in normal controls.
The rs13180 (IREB2 (显示 IREB2 抗体)), rs16969968 (CHRNA5) and rs1051730 (CHRNA3 (显示 CHRNA3 抗体)) were significantly associated with Chronic obstructive pulmonary disease (COPD (显示 ARCN1 抗体)) in additive model [Padj =0.00001, odds ratio (OR)=0.64; Padj =0.0001, OR=1.41 and Padj =0.0001, OR=1.47]. The C-G haplotype by rs13180 and rs1051730 was a protective factor for COPD (显示 ARCN1 抗体) in our population (Padj =0.0005, OR=0.61).
Our present study suggested that rs667282 in CHRNA5-A3 may modify the prognosis of patients with advanced non-small cell lung cancer
our results show that a genomic region with functionally related genes, such as the CHRNA5/CHRNA3/CHRNB4 cluster, is under coordinated regulatory control.
The minor allele increased the risk of COPD (显示 ARCN1 抗体) when compared to the population at large. Homozygosity for the risk allele was associated in both cohorts with all-cause mortality, with any type of cancer among the COPD (显示 ARCN1 抗体) patients and with the number of pack-years among the male smokers.
The data replicate previous result suggesting CHRNA5 as a candidate gene for chronic obstructive pulmonary disease (COPD (显示 ARCN1 抗体)) and rs8040868 as a risk variant for the development of COPD (显示 ARCN1 抗体) in the Swedish population.
The results of this study suggests a pleiotropic role of Chr15q25 CHRNA5-CHRNA3-CHRNB4 gene cluster with complex influences in ADHD, tobacco smoking and cognitive performance.
Polymorphisms in the CHRNA5 and NRXN1 (显示 NRXN1 抗体) genes, influenced greater consumption of cigarettes in a Mexican Mestizo population.
RP11 (显示 PRPF31 抗体)-650L12.2 rs149941240 polymorphism was associated with the risk of colorectal cancer.
We determined that the other patients harbored mutations in genes that have not previously been linked to RTT or other neurodevelopmental syndromes, such as the ankyrin repeat containing protein (显示 EHMT2 抗体) ANKRD31 or the neuronal acetylcholine receptor subunit alpha-5 (CHRNA5).
The findings reveal a proaddiction adaptive response to chronic nicotine in which nitric oxide and SST (显示 SST 抗体) are released by a specific CHRNA5-expressing neuronal population to provide retrograde inhibition of the habenula- interpeduncular nucleus circuit and thereby enhance the motivational properties of nicotine.
Genetic deletion of alpha5 nAChR (显示 CHRNA4 抗体) subunits leads to a behavioural phenotype that exactly matches that observed after antagonizing dopamine receptors.
Chrna5 KO mice did not exhibit high responses to novelty but showed decreased novelty-induced rearing behaviour together with high anxiety. Exposure to high doses of nicotine rescued these phenotypes. Results suggest that altered alpha5*-nAChR (显示 CHRNA4 抗体) cholinergic signalling contributes to emotional/behavioural impairments that may be alleviated by nicotine consumption.
These results highlight the involvement of the alpha5 nAChR (显示 CHRNA4 抗体) subunit in the development of hyperalgesia, allodynia and inflammation associated with chronic neuropathic and inflammatory pain models.
Overexpression of the genomic cluster CHRNA5/A3/B4 in mice increases somatic signs associated with morphine withdrawal and Knockout of alpha5 gene reduced somatic signs in morphine-treated mice
Data reveal a highly regulated temporal-spatial pattern of alpha5 nAChR (显示 CHRNA4 抗体) subunit expression during important periods of lung morphogenesis by FoxA2 (显示 FOXA2 抗体).
increased nicotine intake in mice with a null mutation in Chrna5
Polymorphisms located within the Chrna5-Chrna3-Chrnb4 cluster on mouse chromosome 9 were found to co-segregate with alcohol preference, with high-drinking F(2) mice carrying B6 alleles and low-drinking F(2) mice carrying D2 alleles.
The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).
neuronal acetylcholine receptor subunit alpha-5
, cholinergic receptor, nicotinic, alpha polypeptide 5
, Cholinergic receptor, neuronal nicotinic, alpha polypeptide-5
, acetylcholine receptor, nicotinic, alpha 5 (neuronal)
, neuronal nicotinic acetylcholine receptor, alpha5 subunit
, acetylcholine receptor alpha 5
, cholinergic receptor neuronal nicotinic alpha protein 5
, nicotinic acetylcholine receptor alpha5 subunit