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The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. 再加上，我们可以发Chloride Channel 4 抗体 (47)和数多这个蛋白质的别的产品。
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In Mus (显示 TRPV6 蛋白) spretus, the chloride channel 4 gene Clcn4-2 is X-linked and dosage compensated by X up-regulation and X inactivation, while in the closely related mouse species Mus (显示 TRPV6 蛋白) musculus, Clcn4-2 has been translocated to chromosome 7.
This study performed whole exome sequencing demonistrated that the true de novo variants represent mutations in genes (KCNH5 (显示 KCNH5 蛋白), CLCN4, and ARHGEF15 (显示 ARHGEF15 蛋白)) not previously associated with epilepsies in humans.
the voltage dependence of uncoupled ClC-4 by protons and anions
CLCN4 is a novel driver of colon cancer progression.
Studies showed that three novel CLC-5 (显示 CLCN5 蛋白) mutations were identified, and mutations in OCRL1 (显示 OCRL 蛋白), CLC-4 and cofilin (显示 CFL1 蛋白) excluded in causing Dent's disease.
ClC-4 is an intracellular chloride channel (显示 CLCA1 蛋白) that stimulates copper incorporation into ceruloplasmin (显示 CP 蛋白), probably by improving the efficiency of the ATP7B (显示 ATP7B 蛋白) copper pump.
coupled Cl-/H+ transport of ClC-4 and ClC-5 (显示 CLCN5 蛋白) is of significant magnitude in vivo
crystal structure: CLIC4 (显示 CLIC4 蛋白) appears to be able to form a redox-regulated ion channel in the absence of any partner proteins
The proposed mechanism results in anion-dependent conversion of ClC (显示 CLC 蛋白)-type exchanger into an anion channel with typical attributes of ClC (显示 CLC 蛋白) anion channels.
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins.
chloride channel 4
, H(+)/Cl(-) exchange transporter 4
, chloride channel protein 4
, chloride transporter ClC-4
, voltage-gated chloride channel ClC-4A
, chloride channel 4-2
, putative chloride channel (similar to Mm Clcn4-2)
, putative chloride channel 4-2