Chloride Channel 4 蛋白 (CLCN4)

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. 再加上,我们可以发Chloride Channel 4 抗体 (50)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
CLCN4 12727 Q61418
CLCN4 1183 P51793
大鼠 CLCN4 CLCN4 60586  
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大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
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大肠杆菌(E. Coli) 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
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Insect Cells 小鼠 rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 60至65个工作日
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Insect Cells rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 60至65个工作日
$10,888.92
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CLCN4 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine) ,
,
Human ,
,

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Mouse (Murine) Chloride Channel 4 (CLCN4) interaction partners

  1. In Mus (显示 TRPV6 蛋白) spretus, the chloride channel 4 gene Clcn4-2 is X-linked and dosage compensated by X up-regulation and X inactivation, while in the closely related mouse species Mus (显示 TRPV6 蛋白) musculus, Clcn4-2 has been translocated to chromosome 7.

Human Chloride Channel 4 (CLCN4) interaction partners

  1. This study performed whole exome sequencing demonistrated that the true de novo variants represent mutations in genes (KCNH5 (显示 KCNH5 蛋白), CLCN4, and ARHGEF15 (显示 ARHGEF15 蛋白)) not previously associated with epilepsies in humans.

  2. the voltage dependence of uncoupled ClC-4 by protons and anions

  3. CLCN4 is a novel driver of colon cancer progression.

  4. Studies showed that three novel CLC-5 (显示 CLCN5 蛋白) mutations were identified, and mutations in OCRL1 (显示 OCRL 蛋白), CLC-4 and cofilin (显示 CFL1 蛋白) excluded in causing Dent's disease.

  5. ClC-4 is an intracellular chloride channel (显示 CLCA1 蛋白) that stimulates copper incorporation into ceruloplasmin (显示 CP 蛋白), probably by improving the efficiency of the ATP7B (显示 ATP7B 蛋白) copper pump.

  6. coupled Cl-/H+ transport of ClC-4 and ClC-5 (显示 CLCN5 蛋白) is of significant magnitude in vivo

  7. crystal structure: CLIC4 (显示 CLIC4 蛋白) appears to be able to form a redox-regulated ion channel in the absence of any partner proteins

  8. The proposed mechanism results in anion-dependent conversion of ClC (显示 CLC 蛋白)-type exchanger into an anion channel with typical attributes of ClC (显示 CLC 蛋白) anion channels.

蛋白简介Chloride Channel 4 (CLCN4)

蛋白简介

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins.

Gene names and symbols associated with Chloride Channel 4 蛋白 (CLCN4)

  • chloride voltage-gated channel 4 (CLCN4)
  • chloride channel, voltage-sensitive 4 (clcn4)
  • chloride channel, voltage-sensitive 4 (Clcn4)
  • chloride voltage-gated channel 4 (Clcn4)
  • ClC-4 蛋白
  • ClC-4A 蛋白
  • CLC4 蛋白
  • Clc4-2 蛋白
  • Clcn4 蛋白
  • Clcn4-2 蛋白

Protein level used designations for Chloride Channel 4 蛋白 (CLCN4)

chloride channel 4 , H(+)/Cl(-) exchange transporter 4 , chloride channel protein 4 , chloride transporter ClC-4 , clC-4 , voltage-gated chloride channel ClC-4A , chloride channel 4-2 , putative chloride channel (similar to Mm Clcn4-2) , putative chloride channel 4-2

GENE ID SPECIES
428005 Gallus gallus
491736 Canis lupus familiaris
511699 Bos taurus
100145074 Xenopus (Silurana) tropicalis
12727 Mus musculus
1183 Homo sapiens
60586 Rattus norvegicus
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