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May be involved in sphingolipid synthesis or its regulation (By similarity).. 再加上，我们可以发Ceramide Synthase 6 蛋白 (7) 和 Ceramide Synthase 6 试剂盒 (4)和数多这个蛋白质的别的产品。
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Human Polyclonal CERS6 Primary Antibody for ELISA, WB - ABIN566978
Senkal, Ponnusamy, Rossi, Bialewski, Sinha, Jiang, Jazwinski, Hannun, Ogretmen: Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas. in Molecular cancer therapeutics 2007
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Human Monoclonal CERS6 Primary Antibody for IHC (p), ELISA - ABIN566979
: in 1970
Show all 7 Pubmed References
ceramide synthase (CerS)6 was specifically up-regulated in zone 3 hepatocytes in alcoholic steatosis
This study has shown that by direct transcriptional activation of CerS6, p53 (显示 TP53 抗体) can regulate specific ceramide biosynthesis, which contributes to the pro-apoptotic cellular response.
silencing of CerS6 induced the increased expression of GLUT1 (显示 SLC2A1 抗体), which downregulated the expression of WNT5A (显示 WNT5A 抗体) and enhanced the invasion and proliferation of melanoma cells.
Identification of CerS6 and ceramide pathways as a novel Methotrexate target.
stichoposide D inhibits growth of experimental leukemia by activating Fas (显示 FAS 抗体)/ceramide synthase 6/p38 (显示 CRK 抗体) kinase in lipid rafts
CERS6-dependent ceramide synthesis and maintenance of ceramide in the cellular membrane are essential for lamellipodia formation and metastasis.
Data indicate that ceramide synthase 6 (CerS6) expression is upregulated in leukocytes from multiple sclerosis (MS) patients.
On the basis of its pivotal role in regulating cell death upon COX (显示 COX8A 抗体) dysfunction, CerS6 might potentially represent a novel target for therapeutic intervention in mitochondrial diseases caused by COX (显示 COX8A 抗体) dysfunction.
Taken together, these results suggest that increased expression of CerS6 can mediate transcriptional activation of acid ceramidase (显示 ASAH1 抗体) in a JNK (显示 MAPK8 抗体)-dependent manner that is independent of CerS6 activity.
CerS6 as a novel epithelial-mesenchymal transition-regulated gene that has a pivotal role in the regulation of cell migration.
ceramide synthase (CerS)6 was specifically up-regulated in experimental alcoholic steatosis in vivo and in vitro
CerS1 (显示 CERS1 抗体), -2, and -6 are hyperacetylated in the mitochondria of SIRT3 (显示 SIRT3 抗体)-null mice.
CerS6 deletion increases energy expenditure and improves glucose tolerance, not only in CerS6(Delta/Delta) mice, but also in brown adipose tissue- (CerS6(DeltaBAT)) and liver-specific (CerS6(DeltaLIVER)) CerS6 knockout mice.
Data show that ceramide synthase 6 knockout (CerS6KO) experimental autoimmune encephalomyelitis (EAE) mice exhibit exacerbated progression of clinical symptoms.
Data indicate that oxidized phospholipids (OxPLs)-induced ceramide synthases (CerS1 (显示 CERS1 抗体)-Cers6) activity in macrophages is responsible for the accumulation of ceramide.
CerS6 protein is N-glycosylated and expressed in several tissues of mice, mainly kidney, small and large intestine, and brain.
An important role is revealed for C16:0-Cer (显示 CBLN1 抗体) (ceramide synthase 6) in the inflammatory process and subsequently in the induction of experimental autoimmune encephalitis.
Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6 (显示 ATF6 抗体)-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2 (显示 CA2 抗体)+ and ER/Golgi membrane network
May be involved in sphingolipid synthesis or its regulation (By similarity).
LAG1 homolog, ceramide synthase 6
, longevity assurance homolog 6
, LAG1 longevity assurance homolog 6