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Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase 蛋白

(Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB))
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T- cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. {ECO:0000269|PubMed:10646608, ECO:0000269|PubMed:10646609, ECO:0000269|PubMed:11070165, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:12771181, ECO:0000269|PubMed:15308098}.
Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 1-982) protein (GST tag) Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 1-982) protein (GST tag) Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 1-982) protein (GST tag) (ABIN1348172)

CBLB 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 39-426) protein (His tag) Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 39-426) protein (His tag) Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 39-426) protein (His tag) (ABIN7122186)

CBLB 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 21-129) protein (GST tag) Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 21-129) protein (GST tag) Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 21-129) protein (GST tag) (ABIN1348174)

CBLB 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase 蛋白 by Grade

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Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase 蛋白 by Origin

Find Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase 蛋白 for a variety of species such as anti-Human Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase, anti-Mouse Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase. The species listed below are among those available. Click on a link to go to the corresponding products.

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase 蛋白 by Source

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Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase 蛋白 by 蛋白类型

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Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase 蛋白 by 应用范围

Find Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase 蛋白 validated for a specific application such as ELISA, WB, AP, AA. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1348172
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122186
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1348174
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3134985
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3090503
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2713255
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase 蛋白

Gruber, Hinterleitner, Hermann-Kleiter, Meisel, Kleiter, Wang, Viola, Pfeifhofer-Obermair, Baier: "Cbl-b mediates TGF? sensitivity by downregulating inhibitory SMAD7 in primary T cells." in: Journal of molecular cell biology, Vol. 5, Issue 6, pp. 358-68, (2013) (PubMed).

Aliases for Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase 蛋白

Cbl proto-oncogene B, E3 ubiquitin protein ligase S homeolog (cblb.S) 蛋白
Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog (cblb.L) 蛋白
Casitas B-lineage lymphoma b (Cblb) 蛋白
Cbl proto-oncogene B (Cblb) 蛋白
Cbl proto-oncogene B (CBLB) 蛋白
AI429560 蛋白
AI851073 蛋白
Cbl-b 蛋白
cblb 蛋白
rnf56 蛋白
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