Cathepsin C 蛋白 (CTSC)

The protein encoded by CTSC, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. 再加上,我们可以发Cathepsin C 抗体 (101)Cathepsin C 试剂盒 (38)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
CTSC 1075 P53634
CTSC 13032 P97821
CTSC 25423 P80067
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
人细胞 His tag 10 μg Log in to see 14至16个工作日
$250.80
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大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
$5,370.21
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大肠杆菌(E. Coli) 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
$5,370.21
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
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大肠杆菌(E. Coli) His tag 100 μg Log in to see 15至18个工作日
$752.00
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大肠杆菌(E. Coli) 小鼠 His tag 100 μg Log in to see 15至18个工作日
$768.00
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$888.80
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人细胞 His tag   50 μg Log in to see 4 Days
$385.00
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
$340.00
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CTSC 蛋白 by Origin and Source

Origin 在表达 标记
Human , , , ,
, ,
Mouse (Murine) ,

Rat (Rattus)

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Human Cathepsin C (CTSC) interaction partners

  1. expression markedly increased in the maternal vascular endothelium in subjects with preeclampsia compared with normal pregnant controls

  2. A compound mutation consisting of a large deletion and a nonsense mutation, which provides a new insight in the mutation type of CTSC gene.

  3. CTSC gene missense mutation is responsible for Papillo- Lefevre syndrome in a Turkish family.

  4. analysis of fluorescent substrates provides a detailed S' specificity study of cathepsin C

  5. Mutation screening of the CTSC gene from the two patients revealed the presence of the same homozygous nonsense mutation in Papillon-Lefevre syndrome and Haim-Munk syndromes. Phenotypic variants of the same rare disease caused by mutations of the cathepsin C (CTSC) gene.

  6. Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases.

  7. CTSC was associated with albuminuria in type 2 diabetes patients.

  8. Homozygous mutation 901G>A in exon 7 of CTSC gene is associated with Papillon-Lefevre syndrome.

  9. Results identify a missense mutation in CTSC gene that segregate within a family with Papillon-Lefevre syndrome.

  10. Papillon-Lefevre syndrome cause by homozygous nonsense mutation of cathepsin C gene.

  11. CatC has a role in the selective tuning of innate and adaptive immune responses, relevant to a chronic immune disease, such as atherosclerosis.

  12. cathepsin C in GCF does not seem to have an effect on the pathogenesis of periodontal diseases.

  13. The present account of the 148.621 kb homozygous deletion on chromosome 11 is the first report of a mutational mechanism encompassing the whole CTSC gene.

  14. CTSC mutations in 5 Iranian families with Papillon-Lefevre syndrome (PLS)analyzed; modeled the protein for mutations found in 2 of them; presence of this mutation provides evidence for founder CTSC mutations in PLS; this P35delL mutation leads to loss of a leucine residue; results indicate the phenotypes in these 2 patients likely due to CTSC mutations

  15. Report novel deletion mutation in CTSC gene in Hungarian family with Papillon-Lefevre syndrome.

  16. Cathepsin C gene 5'-untranslated region mutation in papillon-lefevre syndrome in 4 unrelated families in Slovenia

  17. The novel loss-of function mutation of CTSC gene (c.203 T > G) found in Papillon-Lefevre Syndrome patients correlated with their diminished enzymatic activity.

  18. present a catalytic model derived from the relative rates of the acylation vs deacylation half-reactions of cathepsin C.

  19. The Cathepsin C releases the glycosidases from complexes formed with cathepsin A, and reinstates their activity.

  20. Two Indian siblings present with Haim Munk syndrome (HMS) and its cardinal features including palmoplantar keratoderma, periodontitis. arachnodactyly, acroosteolysis, onychogryphosis, osteopenia as well as allelic mutation of cathepsin C exon 6 codon.

Mouse (Murine) Cathepsin C (CTSC) interaction partners

  1. During the active remyelinating phase, both CysF knockdown (CysFKD) and microglial-selective CatC overexpression (CatCOE) showed a worsening of the demyelination in Plp(4e/-) transgenic mice. Conversely, during the chronic demyelinating phase, CatC knockdown (CatCKD) ameliorated the demyelination. Our results suggest that the balance between CatC and CysF expression controls the demyelination and remyelination process.

  2. Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases.

  3. A proteolytic cascade, involving cathepsins C and D, controls LLOMe-mediated necrosis.

  4. Double immunofluorescence analysis showed that CTLA-2alpha was co-localized with cathepsin L, cathepsin C, and TINAGL1 in placenta.

  5. CatC has a role in the selective tuning of innate and adaptive immune responses, relevant to a chronic immune disease, such as atherosclerosis.

  6. Data indicate that all-trans retinoic acid (ATRA), which induces miR-23a expression, decreases cathepsin C (CTSC) expression and granzyme B activity leading to impaired NK cell cytotoxicity.

  7. These results establish that DPPI is a major determinant of survival following Klebsiella pneumoniae lung infection and suggest that the survival disadvantage in DPPI(+/+) mice is in part due to processing of surfactant protein D by DPPI.

  8. found no significant role for CtsC during mammary carcinogenesis but revealed squamous carcinogenesis to be functionally dependent on CtsC

  9. Late stage cathepsin C, CXCL13 and Ki-67 overexpression correlate with regional neuropathology in a bovine spongiform encephalopathy transgenic murine model.

  10. Proinflammatory cytokines induce expression and release of cathepsin C in microglial cells during neuroinflammatory progression.

  11. The production of IL-1beta by macrophages, neutrophils, and mast cells in vitro is dependent on caspase-1 but not on cathepsin C.

  12. NADPH oxidase in antimicrobial host defense against A. fumigatus and B. cepacia, whereas the proteases neutrophil elastase, cathepsin G, and lysosomal cysteine protease cathepsin C/ dipeptidyl peptidase I are dispensable

  13. CatC is involved in limiting MCMV replication; however, this effect is independent of its role in promoting effector cytolytic activity.

  14. Results indicate that mast cell dipeptidyl peptidase I (DPPI) harms the septic host and that DPPI is a novel potential therapeutic target for treatment of sepsis.

  15. DPPI regulates a critical step in the development of collagen-induced arthritis that is independent of T cell and B cell functions.

  16. Overall, our results indicate that although cathepsin C clearly generates the majority of granzyme B activity, some is still generated in its absence, pointing to alternative mechanisms for granzyme B processing and activation.

  17. These findings suggest that DPPI and/or granule-associated serine proteases are necessary for neutrophil recruitment into the diseased aorta and that these proteases act to amplify vascular wall inflammation that leads to abdominal aortic aneurysms.

  18. Role of DPPI and TIMP-3 in development of pulmonary fibrosis in early inflammation following bleomycin instillation.

  19. DPPI is involved in recruitment of neutrophils following respiratory viral infection; absence of neutrophil-derived DPPI diminishes the acute inflammatory response and mucous cell metaplasia of the chronic asthma that follows Sendai virus infection.

  20. Results indicate that DPPI cannot functionally compensate for the loss of TPPI.

蛋白简介Cathepsin C (CTSC)

蛋白简介

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Cathepsin C 蛋白 (CTSC)

  • cathepsin C (CTSC)
  • cathepsin C L homeolog (ctsc.L)
  • cathepsin C (ctsc)
  • cathepsin C (TP03_0357)
  • cathepsin C (CMU_003360)
  • cathepsin CPC1 (CPC1)
  • cathepsin C (NAEGRDRAFT_80477)
  • cathepsin C (NAEGRDRAFT_37577)
  • cathepsin C (Ctsc)
  • cathepsin C (Smp_183330)
  • AI047818 蛋白
  • CATC 蛋白
  • cb912 蛋白
  • CPPI 蛋白
  • DPP-I 蛋白
  • DPP1 蛋白
  • DPPI 蛋白
  • HMS 蛋白
  • ik:tdsubc_1h2 蛋白
  • JP 蛋白
  • JPD 蛋白
  • MGC69126 蛋白
  • MGC107782 蛋白
  • PALS 蛋白
  • PDON1 蛋白
  • PLS 蛋白
  • sb:cb146 蛋白
  • wu:fb34g12 蛋白
  • wu:fj58d01 蛋白

Protein level used designations for Cathepsin C 蛋白 (CTSC)

cathepsin J , dipeptidyl peptidase 1 , dipeptidyl peptidase I , dipeptidyl transferase , dipeptidyl-peptidase I , cathepsin C , dipeptidyl peptidase 1 isoform a preproprotein , DPPI , DPP-I , Dipeptidyl-peptidase 1 , dipeptidyl-peptidase 1 , dipeptidylpeptidase 1

GENE ID SPECIES
1075 Homo sapiens
380203 Xenopus laevis
407938 Xenopus (Silurana) tropicalis
419014 Gallus gallus
451469 Pan troglodytes
705320 Macaca mulatta
3500364 Theileria parva strain Muguga
6997925 Cryptosporidium muris RN66
7899372 Toxoplasma gondii ME49
8851692 Naegleria gruberi strain NEG-M
8855504 Naegleria gruberi strain NEG-M
100172530 Pongo abelii
13032 Mus musculus
25423 Rattus norvegicus
352958 Bos taurus
403458 Canis lupus familiaris
100101594 Oryctolagus cuniculus
100714387 Cavia porcellus
101112686 Ovis aries
8346758 Schistosoma mansoni
368704 Danio rerio
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