anti-Cartilage Oligomeric Matrix Protein (COMP) 抗体

The protein encoded by COMP is a noncollagenous extracellular matrix (ECM) protein. 再加上,我们可以发COMP 试剂盒 (81)COMP 蛋白 (22)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
COMP 25304 P35444
COMP 1311 P49747
COMP 12845 Q9R0G6
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antibodies-online.cn销售最多的anti-COMP 抗体

Showing 10 out of 128 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 FACS, IHC (p), WB Western blot analysis of COMP Antibody (Center) (ABIN390893) in Jurkat cell line lysates (35 µg/lane). COMP (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with COMP Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10至11个工作日
$335.50
详细
非结合性 EIA, WB 0.4 mL Log in to see 6至8个工作日
$390.50
详细
小鼠 非结合性 ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Rat Heart Tissue; Lane2: Mouse Heart Tissue. 100 μg Log in to see 15至18个工作日
$288.00
详细
Cow 非结合性 WB Host:  Rabbit  Target Name:  COMP  Sample Type:  786-0 Whole Cell lysates  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2至3个工作日
$289.00
详细
小鼠 非结合性 IHC, IHC (p), WB Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) 100 μg Log in to see 11至14个工作日
$639.83
详细
非结合性 WB Raji cell lysates probed with Rabbit Anti-COMP Polyclonal Antibody, Unconjugated (ABIN2559644) at 1:300 in 4˚C. Followed by conjugation to secondary antibody at 1:5000 for 90min at 37˚C. 100 μL Log in to see 3至7个工作日
$306.90
详细
小鼠 非结合性 ICC, IHC, WB Figure.DAB staining on IHC-P. Samples: Mouse Tissue 100 μg Log in to see 13至16个工作日
$288.00
详细
小鼠 非结合性 ICC, IHC, WB Figure.DAB staining on IHC-P. Samples: Mouse Tissue 100 μg Log in to see 13至16个工作日
$288.00
详细
非结合性 ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Human Cartilage Tissue; Lane2: Mouse Cartilage Tissue. 100 μg Log in to see 13至16个工作日
$332.00
详细
大鼠 非结合性 ICC, IHC, WB Figure.DAB staining on IHC-P. Samples: Rat Tissue 100 μg Log in to see 13至16个工作日
$362.00
详细

引用最多的anti-COMP 抗体

  1. Human Polyclonal COMP Primary Antibody for WB - ABIN947722 : Clement, Aphkhazava, Nieves, Callaway, Olszewski, Rotzschke, Santambrogio: Protein expression profiles of human lymph and plasma mapped by 2D-DIGE and 1D SDS-PAGE coupled with nanoLC-ESI-MS/MS bottom-up proteomics. in Journal of proteomics 2013 (PubMed)

更多抗COMP的相互作用对抗体

Horse (Equine) Cartilage Oligomeric Matrix Protein (COMP) interaction partners

  1. The aims of this study were to investigate the proteomic composition of injured tendons during early and late disease stages to identify disease-specific cleavage patterns of the extracellular matrix protein cartilage oligomeric matrix protein (COMP).

  2. The present results suggest that not only type III collagen (显示 COL3A1 抗体) but also cartilage oligomeric matrix protein is involved in the repair and remodeling processes of the digital flexor tendon.

  3. Within the limitations of the study design, production of COMP during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 (显示 TGFB1 抗体) concentrations.

  4. COMP concentrations in digital flexor tendon sheath synovial fluid were significantly greater than those in normal horses with noninfected tenosynovitis caused by intrathecal tendon/ligament tearing, but not by other lesions.

  5. The present study indicates that dynamic in vivo compression at high load and frequency lowers matrix content of COMP in the articular cartilage of the third carpal bone.

Human Cartilage Oligomeric Matrix Protein (COMP) interaction partners

  1. Higher serum COMP levels in knee osteoarthritis reflect knee structural damage.

  2. COMP (and C-reactive protein (显示 CRP 抗体)) serum levels were both associated with the incidence of knee osteoarthritis.

  3. Data indicate cartilage oligomeric matrix protein (COMP) homozygote missense variant [c.1423G>A; p.(D475N)] in 2 severely affected pseudoachondroplasia individuals.

  4. The serum COMP is a promising biomarker in rheumatoid arthritis which reflects disease activity and damage to the articular cartilage.

  5. the novel mutation of COMP may result in intracellular accumulation of the mutant protein. Decreased plasma COMP and increased plasma CTX (显示 CYP27A1 抗体)-II may potentially serve as diagnostic markers of PSACH but may not be applicable in the presymptomatic carrier.

  6. COMP promoted colon cancer cell proliferation partially through the activation of PI3K (显示 PIK3CA 抗体)/ Akt (显示 AKT1 抗体)/ mTOR (显示 FRAP1 抗体)/ p70S6K (显示 RPS6KB1 抗体) pathway.

  7. The findings suggest that upregulation of ADAMTS-7 (显示 ADAMTS7 抗体) and down regulation of COMP are associated with human AA.

  8. Data show that a rare missense variant in the COMP gene (cartilage oligomeric matrix protein) and a frameshift variant in the CHADL gene (chondroadherin-like protein) strongly associate with osteoarthritis total hip replacement.

  9. COMP is a novel biomarker in breast cancer, which contributes to the severity of the disease by metabolic switching and increasing invasiveness and tumor cell viability, leading to reduced survival in animal models and human patients.

  10. The average sCOMP level was highest among the controls and lowest among the infected children. In the juvenile idiopathic arthritis patients, the level of sCOMP was not associated with the level of CRP (显示 CRP 抗体) or with clinical signs of disease activity.

Mouse (Murine) Cartilage Oligomeric Matrix Protein (COMP) interaction partners

  1. COMP could normally have a protective role against PASMC phenotype switching

  2. these findings revealed the essential role of COMP in retarding the development of vascular aging and vascular smooth muscle cell senescence.

  3. COMP deficiency drove macrophages toward the atherogenic phenotype and thereby aggravated atherosclerotic calcification.

  4. COMP forms a complex with collagens intracellularly that is a prerequisite for collagen secretion.

  5. COMP-Ang1 (显示 ANGPT1 抗体) can enhance BMP2 (显示 BMP2 抗体)-induced cranial bone regeneration with increased pericyte recruitment. Combined delivery of the proteins might be a therapeutic strategy to repair cranial bone damage.

  6. COMP deficiency shortened tail-bleeding and clotting time and accelerated ferric-chloride-induced thrombosis. COMP specifically inhibited thrombin-induced platelet aggregation, activation, and retraction and the thrombin-mediated cleavage of fibrinogen.

  7. COMP immunoreactivity was observed in about half of the investigated plaques from the ApoE (显示 APOE 抗体) null mice, mainly located along the intima-medial border. Plaques in the brachiocephalic artery from ApoE (显示 APOE 抗体) mice lacking COMP were increased in size with 54%.

  8. study will facilitate better awareness of the differential diagnoses that might be associated with the PSACH/MED spectrum and subsequent care of PSACH/MED patients

  9. The lack of arthritis, together with high levels of COMP-specific antibodies, in COMP-deficient mice indicates that susceptibility to arthritis is COMP specific and that endogenous expression of COMP in wild-type mice tolerizes B cells in vivo.

  10. results imply that COMP is not a key upstream mediator of the anabolic effects of ML on the skeleton.

Cow (Bovine) Cartilage Oligomeric Matrix Protein (COMP) interaction partners

  1. COMP synthesis is differentially regulated by TGFbeta1 (显示 TGFB1 抗体) in the surface and middle zones of bovine articular cartilage.

  2. role for proteinases other than MMPs in the degradation of COMP in cartilage

  3. COMP mutant expression in tendon fibroblasts leads to increased apoptotic cell death irrespective of the secretory characteristics of mutant COMP

  4. COMP mRNA expression level was markedly increased by ball oscillation.

  5. COMP acts as a catalyst in collagen fibrillogenesis.

COMP 抗原简介

蛋白简介

The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).

Gene names and symbols associated with COMP

  • cartilage oligomeric matrix protein (COMP) 抗体
  • cartilage oligomeric matrix protein (sce3551) 抗体
  • cartilage oligomeric matrix protein (CJA_1292) 抗体
  • cartilage oligomeric matrix protein (Comp) 抗体
  • COMP 抗体
  • EDM1 抗体
  • EPD1 抗体
  • MED 抗体
  • PSACH 抗体
  • THBS5 抗体
  • TSP5 抗体

Protein level used designations for COMP

cartilage oligomeric matrix protein , TSP5 , cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) , cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple) , pseudoachondroplasia (epiphyseal dysplasia 1, multiple) , thrombospondin-5 , putative cartilage oligomeric matrix protein

GENE ID SPECIES
469068 Pan troglodytes
5808591 Sorangium cellulosum So ce56
6415089 Cellvibrio japonicus Ueda107
100033911 Equus caballus
25304 Rattus norvegicus
1311 Homo sapiens
12845 Mus musculus
281088 Bos taurus
100720040 Cavia porcellus
396554 Sus scrofa
476665 Canis lupus familiaris
420120 Gallus gallus
101107864 Ovis aries
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