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Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. 再加上，我们可以发TNNC1 抗体 (101) 和 TNNC1 试剂盒 (12)和数多这个蛋白质的别的产品。
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Rationally engineered TnC constructs corrected the abnormal Ca(2+) sensitivities of the thin filament, reconstituted actomyosin ATPase activity
Molecular effects of cardiac troponin C mutations present in hypertrophic cardiomyopathy on calcium sensitivity and myofilament activation have been reported.
Study shows that over-expression of MFAP5 (显示 MFAP5 蛋白) and TNNC1 is correlated with cervical lymph node metastasis (CLNM), metastasis relapse-free survival and overall survival. These results propose that MFAP5 (显示 MFAP5 蛋白) and TNNC1 may be potential markers for predicting occult cervical lymphatic metastasis and prognosis of oral tongue carcinoma.
Our results (i) confirm that genetic backgrounds of hypertrophic cardiomyopathy and restrictive cardiomyopathy overlap and (ii) indicate that TNNC1 is a likely novel gene for autosomal recessive restrictive cardiomyopathy.
Data suggest that modulation of structural dynamics far from the regulatory Ca2 (显示 CA2 蛋白)+-binding site is the underlying molecular mechanism for many TNNC1 mutations in patients with hypertrophic cardiomyopathies or familial hypertrophic cardiomyopathies; many mutations affect balance between open and closed conformations; troponin I switch peptide [TnI (显示 TNNI2 蛋白)(SW)] switch peptide binds to TNNC1 and stabilizes the open TNNC1 conformation.
Data suggest that mutations in troponin C (TnC (显示 TNNC2 蛋白)) found in patients with hypertrophic cardiomyopathy (A8V, C84Y, and D145E) stabilize the active state of regulated actin (the actin-tropomyosin (显示 TPM2 蛋白)-troponin complex) to various extents; at a saturating Ca2 (显示 CA2 蛋白)+ concentration, all TnC (显示 TNC 蛋白) mutants investigated increase the level of active M state compared to the wild type.
There was no difference in the test characteristics of the HEART Pathway whether using cTnI or hs-cTnI, with both achieving 100% sensitivity and NPV. Use of hs-cTnT with the HEART Pathway was associated with one missed major adverse cardiac events.
contractility is constantly above normal in hearts made hypertrophic by TnC (显示 TNC 蛋白) with the A8V mutation
We used nuclear magnetic resonance and circular dichroism to solve the structure and characterize the backbone dynamics and stability of the regulatory domain of cTnC with the L29Q mutation.
conclusive evidence that TNNC1 is an uncommon but definitive HCM-susceptibility gene
Results suggest that tnnc1a is required both for the function and structural integrity of the contractile machinery in cardiomyocytes, helping to clarify potential mechanisms of troponin C-mediated cardiomyopathy.
Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle.
A region in cTnC associated with increased Ca(2+) sensitivity in skinned fibers was identified, an the F27W reporter mutation affected Ca(2+) sensitivity, maximal force, and ATPase activation of some mutants.
Overexpression of sTnC (显示 TNNC2 蛋白) polypeptide in muscle cells is controlled by its rapid degradation.
These results demonstrate that the L29Q mutation enhances the Ca(2+)-binding characteristics of cTnC and that when incorporated into cardiac myocytes, this mutant alters myocyte contractility.
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase\; TnT, which contains the binding site for tropomyosin\; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z.
cardiac troponin C
, slow twitch skeletal/cardiac muscle troponin C
, troponin C, slow skeletal and cardiac muscles
, troponin C1, slow
, troponin C type 1 (slow)
, troponin C, slow
, Troponin C, slow skeletal and cardiac muscles
, troponin C, cardiac/slow skeletal
, troponin C type 1 slow