BRSK1 抗体
(BR Serine/threonine Kinase 1 (BRSK1))
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Ser-573'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV- induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C (By similarity). In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1.
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BRSK1 抗体 by 适用
Find BRSK1 抗体 for a variety of species such as anti-Human BRSK1, anti-Mouse BRSK1, anti-Rat BRSK1. The species listed below are among those available. Click on a link to go to the corresponding products.
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Find available monoclonal or polyclonal BRSK1 抗体. Click on a link to go to the corresponding products.
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Popular BRSK1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7169019
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Application
WB
Validations
- (3)
- (1)
Cat. No.
ABIN1881121
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, ICC
Validations
- (2)
Cat. No.
ABIN5066517
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, ICC
Validations
- (2)
Cat. No.
ABIN5066519
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, ICC
Validations
- (2)
Cat. No.
ABIN5066516
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN544979
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IF, ICC
Validations
- (2)
Cat. No.
ABIN6256963
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, ICC
Validations
- (2)
Cat. No.
ABIN5066528
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, ICC
Validations
- (2)
Cat. No.
ABIN5066527
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, ICC
Validations
- (2)
Cat. No.
ABIN5066526
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, ICC
Validations
- (2)
Cat. No.
ABIN5066530
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
Cat. No.
ABIN652432
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p), EIA
Validations
- (2)
Cat. No.
ABIN499499
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Rat
Application
ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
Cat. No.
ABIN873206
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
ELISA, IHC (p), IHC (fro)
Validations
Cat. No.
ABIN885576
Quantity
100 μL
Datasheet
Datasheet
Latest Publications for our BRSK1 抗体
: "Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 36, pp. 11938-50, (2010) (PubMed).: "SADB phosphorylation of gamma-tubulin regulates centrosome duplication." in: Nature cell biology, Vol. 11, Issue 9, pp. 1081-92, (2009) (PubMed).
: "C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest." in: The Journal of biological chemistry, Vol. 284, Issue 1, pp. 77-84, (2008) (PubMed).
: "Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation." in: The Journal of biological chemistry, Vol. 283, Issue 22, pp. 14946-54, (2008) (PubMed).
: "Mammalian SAD kinases are required for neuronal polarization." in: Science (New York, N.Y.), Vol. 307, Issue 5711, pp. 929-32, (2005) (PubMed).
: "Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function." in: The Journal of biological chemistry, Vol. 279, Issue 30, pp. 31164-70, (2004) (PubMed).
: "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1." in: The EMBO journal, Vol. 23, Issue 4, pp. 833-43, (2004) (PubMed).
Aliases for BRSK1 抗体
BR serine/threonine kinase 1 (BRSK1) 抗体BR serine/threonine kinase 1 (Brsk1) 抗体
BRSK1 抗体
Gm1100 抗体
hSAD1 抗体
RGD1563268 抗体
SAD-B 抗体
Sad-b 抗体
SADB 抗体
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