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The product of BDP1 is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription.
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Data indicate the crystal structure of a Brf2 (显示 ZFP36L2 抗体)-TBP (显示 TBP 抗体)-Bdp1 (显示 PTPN18 抗体) complex bound to a DNA promoter.
Linkage study and exome sequencing identify a BDP1 (显示 PTPN18 抗体) mutation associated with hereditary hearing loss.
Human BDP1 (显示 PTPN18 抗体) protein represents essential components of TFIIIC1 and TFIIIC1-like activities.
Maf1 occupancy of Pol III genes is inversely correlated with that of the initiation factor TFIIIB (subunit Bdp1) and Pol III
PTEN (显示 PTEN 抗体) represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex
Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss.
The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription.
RNA polymerase III transcription initiation factor B''
, TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1
, transcription factor IIIB 150
, transcription factor TFIIIB component B'' homolog
, transcription factor-like nuclear regulator