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The protein encoded by AIP is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. 再加上，我们可以发AIP 试剂盒 (18) 和 AIP 蛋白 (11)和数多这个蛋白质的别的产品。
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Human Monoclonal AIP Primary Antibody for ChIP, FACS - ABIN151058
Petrulis, Hord, Perdew: Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2. in The Journal of biological chemistry 2000
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Human Polyclonal AIP Primary Antibody for ELISA, WB - ABIN253295
Vierimaa, Georgitsi, Lehtonen, Vahteristo, Kokko, Raitila, Tuppurainen, Ebeling, Salmela, Paschke, Gündogdu, De Menis, Mäkinen, Launonen, Karhu, Aaltonen: Pituitary adenoma predisposition caused by germline mutations in the AIP gene. in Science (New York, N.Y.) 2006
Therefore, both functional and structural studies reveal that N-terminus mutations in the AIP gene alter protein behaviour significantly and hence can truly be pathogenic in nature.
This study of human fibroblasts bearing endogenous heterozygous AIP mutations and transfected pituitary GH3 cells shows that AIP mutations affect the AIP protein level and alter AhR (显示 AHR 抗体) transcriptional activity in a gene- and tissue-dependent manner.
The expression of PDE4A4 and PDE4A8 in normal pituitary, their increased expression in adenomatous pituitary cells where AIP is meant to participate, and the disruption of the PDE4A4-AIP interaction by AIP mutants may play a role in pituitary tumorigenesis.
The aryl hydrocarbon receptor interacting protein (AIP) founder mutation R304(*) is frequent in Mid Ulster, resulting in numerous acromegaly/gigantism cases.
the well-known interaction between AIP and 2 different isoforms of phosphodiesterases (PDEs), PDE2A3 and PDE4A5, is of particular interest. While the interaction with over-expressed AIP does not seem to affect PDE2A3 function, the reported effect on PDE4A5 is, in contrast, reduced enzymatic activity.
The c.805_825dup allele in AIP, originating from a common ancestor, associates with a severe clinical phenotype of gigantism.
The prevalence of AIP mutations in young Mexican patients with acromegaly is similar to that of European cohorts.
Case Report: truncating AIP mutation, p.W279*, in father/daughter presenting with familial isolated pituitary adenoma.
A modest relationship was found between PPARalpha (显示 PPARA 抗体) and AIP expression, both being significantly higher in the presence of pre-operative somatostatin (显示 SST 抗体) analogues in somatotropinoma patients.
The prevalence of AIP(mut (显示 MUT 抗体)) in Turkish patients was found to be 1 % in sporadic acromegaly in the present study.
Results demonstrated that Aip inactivation promoted somatotroph tumorigenesis and overproduction of growth hormone (显示 GH1 抗体) probably through increased Stat3 (显示 STAT3 抗体) activation.
Results provide novel evidence that AIP has an important role in the regulation of cAMP synthesis.
XAP2 exerts a negative effect on ERalpha (显示 ESR1 抗体) transcriptional activity and may thus prevent ERalpha (显示 ESR1 抗体)-dependent events.
Developmental control of apoptosis by the immunophilin (显示 FKBP1A 抗体) aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin (显示 BIRC5 抗体) protein
Mice with inactivation of aryl hydrocarbon receptor-interacting protein display complete penetrance of pituitary adenomas with aberrant ARNT (显示 ARNT 抗体) expression.
Data show that AIP is not required for the induction of the Cyp1a1 (显示 CYP1A1 抗体) and Cyp1a2 (显示 CYP1A1 抗体) genes.
XAP2 hinders importin beta (显示 KPNB1 抗体) binding to the mAhR complex and represses the transactivation potential of the AhR (显示 AHR 抗体) by stabilizing the receptor complex and/or blocking nucleocytoplasmic shuttling of the AhR (显示 AHR 抗体) complex
PPARalpha (显示 PPARA 抗体) is in a complex with hsp90 (显示 HSP90 抗体) and XAP2, and XAP2 appears to function as a repressor
XAP2 has a role in stabilization of the dioxin receptor (显示 AHR 抗体)
The role of Xap2 and C-terminal hsp-70 (显示 HSP70 抗体) interacting protein on the endogenous Ah receptors expressed in mouse cell lines was determined.
The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus.
aryl hydrocarbon receptor interacting protein
, AH receptor-interacting protein-like
, AH receptor-interacting protein
, HBV X-associated protein 2
, immunophilin homolog ARA9
, aryl-hydrocarbon receptor-interacting protein
, HBV-X associated protein
, immunophilin XAP2