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E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin- conjugating enzyme E2 UBE2L3. 再加上，我们可以发和数多这个蛋白质的别的产品。
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Human Polyclonal ARIH1 Primary Antibody for ELISA, WB - ABIN249753
Moynihan, Ardley, Nuber, Rose, Jones, Markham, Scheffner, Robinson: The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1. in The Journal of biological chemistry 1999
Human Polyclonal ARIH1 Primary Antibody for WB - ABIN4281579
von Stechow, Typas, Carreras Puigvert, Oort, Siddappa, Pines, Vrieling, van de Water, Mullenders, Danen: The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest. in Molecular and cellular biology 2015
ARIH1-mediated mitophagy promotes therapeutic resistance.
Variants in ARIH1 are associated with developing aortic aneurysms.
Crystal structure of HHARI and UbcH7 reveals UbcH7 approximately Ub binding RING1 domain of auto-inhibited HHARI.HHARI UBA-L domain has Ub binding properties.
HHARI prevents spurious discharge of Ub from E2 to lysine residues by harboring structural elements that block E2 ~ Ub from adopting a 'closed' conformation.
DNA damage induces an increase in ARIH1 protein levels and association of ARIH1 with 4EHP. In turn, this causes 4EHP recruitment to the mRNA cap, where it is known to compete with eIF4E.
Determined is the three-dimensional solution structure of the catalytic RING2 domain from HHARI. It shows glimpses of a HECT E3 ligase.
TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.
HHARI is a marker of cellular proliferation associated with nuclear bodies.
Both parkin and HHARI bind the same substrate proteins in cells and induce the formation of aggresomes.
UBCH7 exhibits activity with the RING-in-between-RING (RBR) family of E3s that includes parkin (also known as PARK2) and human homologue of ariadne (HHARI; also known as ARIH1)
the structure of the RING2 from the RING-IBR-RING motif of HHARI and showed that RING2 has a completely distinct topology from classical RINGs
2,3,7,8-tetrachlorodibenzo-p-dioxin promotes the aryl hydrocarbon receptor binding to Ubch7 gene promoter as well as its transactivation, resulting in an induction of UbcH7 levels in the olfactory bulb, ventral midbrain, hippocampus, striatum, cerebral cortex, brain stem, and medulla oblongata.
Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7.
E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin- conjugating enzyme E2 UBE2L3. May play a role in protein translation by mediating polyubiquitination of EIF4E2, leading to its subsequent degradation (By similarity).
ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1
, ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)
, E3 ubiquitin-protein ligase arih1
, Protein ariadne-1 homolog
, E3 ubiquitin-protein ligase ARIH1
, ariadne, Drosophila, homolog of
, monocyte protein 6
, protein ariadne-1 homolog
, ubcH7-binding protein
, ubcM4-interacting protein
, ubiquitin-conjugating enzyme E2-binding protein 1
, UbcH7-binding protein
, UbcM4-interacting protein 77
, ariadne 1