anti-Ankylosis, Progressive Homolog (Mouse) (ANKH) 抗体

ANKH encodes a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. 再加上,我们可以发ANKH 蛋白 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
ANKH 56172 Q9HCJ1
ANKH 114506 P58366
ANKH 11732 Q9JHZ2
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Showing 10 out of 40 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-ANKH Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  THP-1 cell lysate 100 μL Log in to see 2至3个工作日
$319.00
详细
非结合性 FACS, IHC (p), WB Western blot analysis of ANKH Antibody (C-term) (ABIN653697) in mouse cerebellum tissue lysates (35 µg/lane). ANKH (arrow) was detected using the purified polyclonal antibody. ANKH Antibody (C-term) (ABIN653697) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10至11个工作日
$385.00
详细
Bat 非结合性 WB 50 μg Log in to see 11至14个工作日
$551.83
详细
非结合性 IHC, WB Immunohistochemistry of paraffin-embedded human prostate using ANKH antibody at dilution of 1:100 (x40 lens). 100 μL Log in to see 16 Days
$366.77
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非结合性 WB Western Blot: ANKH Antibody [NBP1-59748] - Titration: 0.2-1 ug/ml, Positive Control: THP-1 cell lysate. 100 μL Log in to see 8至11个工作日
$488.73
详细
非结合性 FACS, IHC, IHC (p), WB Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-ANKH / ANK antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 200 μL Log in to see 11至14个工作日
$484.00
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非结合性 FACS, IHC (p), WB Flow Cytometry: ANKH Antibody [NBP2-29950] - Flow cytometric analysis of K562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Immunohistochemistry-Paraffin: ANKH Antibody [NBP2-29950] - IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 10至13个工作日
$516.98
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非结合性 FACS, IHC (p), WB   0.4 mL Log in to see 2至3个工作日
$522.50
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非结合性 ELISA, WB   100 μg Log in to see 11至14个工作日
$449.17
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非结合性 ELISA, WB   100 μg Log in to see 11至14个工作日
$449.17
详细

引用最多的anti-ANKH 抗体

  1. Human Polyclonal ANKH Primary Antibody for IHC - ABIN965554 : Ho, Johnson, Kingsley: Role of the mouse ank gene in control of tissue calcification and arthritis. in Science (New York, N.Y.) 2000 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal ANKH Primary Antibody for IHC - ABIN965553 : Williams: Familial calcium pyrophosphate dihydrate deposition disease and the ANKH gene. in Current opinion in rheumatology 2003 (PubMed)
    Show all 3 Pubmed References

更多抗ANKH的相互作用对抗体

Human Ankylosis, Progressive Homolog (Mouse) (ANKH) interaction partners

  1. Craniometaphyseal dysplasia mutations in ANKH diminish hiPSC differentiation into osteoclasts in vitro.

  2. our findings demonstrate that the miR-20a/ANKH axis mediates the stiff matrix- promoted CEP calcification, suggesting that miR-20a and ANKH are potential targets in restraining the progression of IDD.

  3. Results show that ANK localizes to the trans-Golgi network (TGN), clathrin-coated vesicles and the plasma membrane, and is required for endosomal function and endocytosis

  4. This study validates the association between a functional polymorphism in the 5' UTR of ANKH and Chondrocalcinosis

  5. Polymorphisms in ALP, ENPP1 and ANKH are important genetic risk factors contributing to Pseudoxanthoma elasticum

  6. ANK was concentrated around crystal deposits and correlated with markers of chondrocyte hypertrophy. These findings support a role for ANK in CPPD crystal formation in cartilage.

  7. expression levels of type II collagen, aggrecan, and ANK in endplate chondrocytes of experimental group were lower than that of control group and phosphorylation level of JNK in the experimental group which was higher than that in the control group

  8. Exploratory tympanotomy might improve the hearing outcome in patients with this syndrome and therefore surgery has a limited audiometric benefit in general

  9. Analysis of the present CMD family suggested the presence of a maternal mosaicism in an ANKH mutation, and the mother who was mosaic for the ANKH mutation had no apparent clinical or radiological features of CMD.

  10. The aim of this study was to investigate two mineralization-related genes TNAP and ANKH polymorphisms associated with ankylosing spondylitis (AS) in the North Chinese Han population.

  11. Neither ANKH nor ENPP1 mutations are the cause of chondrocalcinosis in these Slovakian families.

  12. TNF-activated NF-kappaB promotes inflammation-accelerated vascular calcification by inhibiting ankylosis protein homolog expression and consequent pyrophosphate secretion.

  13. We report a novel mutation, not previously described, in ANKH exon 1, wherein serine replaces proline, in a case of early-onset severe calcium pyrophosphate disease associated with metabolic abnormalities, with similar findings in the proband's father

  14. These results confirm data in white Europeans that ANKH is probably not a major determinant of susceptibility to ankylosing spondylitis.

  15. in a cohort study of candidate genes and BMD, a few modest associations were observed between SNPs in or near ALPL and several bone traits, but no association was observed with ANKH

  16. Two novel 18 and 12 base pair in-frame deletions are the largest ANKH mutations causing craniometaphyseal dysplasia identified to date.

  17. the relationship between the type of temporomandibular disorders (TMD) and ANKH polymorphisms

  18. Phe377del mutation in ANK causes impaired osteoblastogenesis and osteoclastogenesis resulting in hypomineralization and a high bone mass phenotype.

  19. The ANKH gene was associated with all four studied obesity-related traits, body mass index (BMI), the waist-hip ratio (WHR), the epidermal growth factor receptor (EGFR), and leptin (P<0.0184), and its effects were modulated by sex.

  20. We describe the first human progressive ankylosis phenotype and our results indicate that ANK influences articular soft tissues commonly involved in degenerative joint disorders. also, we provide the first direct evidence for a role of ANK in the CNS.

Pig (Porcine) Ankylosis, Progressive Homolog (Mouse) (ANKH) interaction partners

  1. Data indicate that ankylosis gene product ANK siRNA suppressed basal and hypotonically-stressed ATP levels.

Mouse (Murine) Ankylosis, Progressive Homolog (Mouse) (ANKH) interaction partners

  1. our study provides evidence that ANK plays a critical role in the adipogenic/osteogenic fate decision of adult mesenchymal precursor cells

  2. regulates the transport of inorganic pyrophosphate, and Ank knock-out mice feature a rapidly forming and thick cementum and increased cementum regeneration

  3. Loss of Ank alters cementoblast gene expression and cervical cementum extracellular matrix composition.

  4. the relationship between the type of temporomandibular disorders (TMD) and ANKH polymorphisms

  5. Phe377del mutation in ANK causes impaired osteoblastogenesis and osteoclastogenesis resulting in hypomineralization and a high bone mass phenotype.

  6. ANK is a positive regulator of osteoblastic and osteoclastic differentiation events toward a mature osteoblastic and osteoclastic phenotype.

  7. Analyses on mineralized tissues showed no decrease in mineralization between ank/ank cementum vs. WT controls. Nanoindentation on enamel, dentin or cementum of ank/ank vs. WT molars revealed no significant difference in hardness and elastic modulus.

  8. endogenous expression of ANKH mRNA and protein in whole mouse kidney as well as mouse renal epithelial cell lines and a osteoblast cell line.

  9. Linked regulatory effects on extracellular PP(i) and OPN expression mediate the ability of PC-1 and ANK to regulate calcification.

  10. intra-renal and subcellular localisation of ANK is consistent with pyrophosphate export from collecting duct cells and supports a role for ANK in limiting intra-renal calcium-crystal formation

  11. These results revealed a novel function of ANKH in the promotion of early erythroid differentiation and that ank/ank mice have lower serum levels of Epo than the normal littermates, and this is the likely cause of microcytosis in these mutant mice.

  12. ANK is a positive regulator of differentiation events towards a mature osteoblastic phenotype.

  13. Introduction of a Phe377del mutation in ANK creates a mouse model for craniometaphyseal dysplasia.

  14. ANK expression and function in vitro and in vivo are repressed in hypoxic environments and that the effect is regulated by HIF-1.

ANKH 抗原简介

蛋白简介

This gene encodes a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals. Mutations in this gene have been associated with autosomal dominant craniometaphyseal dysplasia.

Gene names and symbols associated with ANKH

  • ANKH inorganic pyrophosphate transport regulator (ANKH) 抗体
  • ANKH inorganic pyrophosphate transport regulator (Ankh) 抗体
  • progressive ankylosis (Ank) 抗体
  • ANKH inorganic pyrophosphate transport regulator b (ankhb) 抗体
  • ANKH inorganic pyrophosphate transport regulator S homeolog (ankh.S) 抗体
  • ANKH inorganic pyrophosphate transport regulator a (ankha) 抗体
  • ank 抗体
  • ankh 抗体
  • CCAL2 抗体
  • CMDJ 抗体
  • CPPDD 抗体
  • D15Ertd221e 抗体
  • HANK 抗体
  • MANK 抗体
  • mKIAA1581 抗体
  • wu:fc08d03 抗体
  • wu:fj64g09 抗体
  • zgc:110290 抗体

Protein level used designations for ANKH

ankylosis, progressive homolog , progressive ankylosis protein homolog , progressive ankylosis homolog , progressive ankylosis protein , ankylosis, progressive homolog (mouse) , progressive ankylosis protein homolog-like , fn54 protein , ANK-B , progressive ankylosis protein homolog B , progressive ankylosis-like protein , ankylosis, progressive homolog a

GENE ID SPECIES
56172 Homo sapiens
114506 Rattus norvegicus
420917 Gallus gallus
491486 Canis lupus familiaris
511800 Bos taurus
100020529 Monodelphis domestica
100090061 Ornithorhynchus anatinus
100343978 Oryctolagus cuniculus
100400360 Callithrix jacchus
100459252 Pongo abelii
100470006 Ailuropoda melanoleuca
471459 Pan troglodytes
100070193 Equus caballus
100550536 Meleagris gallopavo
100600686 Nomascus leucogenys
100624458 Sus scrofa
11732 Mus musculus
323738 Danio rerio
399193 Xenopus laevis
100719766 Cavia porcellus
571148 Danio rerio
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