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ANGPTL3 encodes a member of a family of secreted proteins that function in angiogenesis. 再加上，我们可以发ANGPTL3 试剂盒 (72) 和 ANGPTL3 蛋白 (28)和数多这个蛋白质的别的产品。
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Human Polyclonal ANGPTL3 Primary Antibody for ELISA, WB - ABIN1169294
Broxmeyer, Srour, Cooper, Wallace, Hangoc, Youn: Angiopoietin-like-2 and -3 act through their coiled-coil domains to enhance survival and replating capacity of human cord blood hematopoietic progenitors. in Blood cells, molecules & diseases 2012
Human Polyclonal ANGPTL3 Primary Antibody for ELISA - ABIN449832
Jin, Wang, Millar, Quertermous, Rothblat, Glick, Rader: Hepatic proprotein convertases modulate HDL metabolism. in Cell metabolism 2007
Knockdown of Angptl3 decreases liver size in developing zebrafish.
ANGPTL8 has a functional LPL (显示 LCP1 抗体) inhibitory motif, but only inhibits LPL (显示 LCP1 抗体) and increases plasma TG levels in mice in the presence of ANGPTL3
Our findings demonstrate that complete ANGPTL3 deficiency associates with highly reduced postprandial lipemia probably due to faster catabolism of intestinally derived lipoproteins, larger expansion of the postprandial FFA pool, and decreased influx of dietary-derived fatty acids into the liver. These results add information on mechanisms underlying hypolipidemia in familial combined hypolipidemia (FHBL2).
participants with heterozygous loss-of-function variants in ANGPTL3 had significantly lower serum levels of triglycerides, HDL (显示 HSD11B1 抗体) cholesterol, and LDL cholesterol than participants without these variants.
ANGPTL3 deficiency is associated with protection from coronary artery disease.
our data shows that ANGPTL3, 4 and 8 are increased in obesity and type 2 diabetes (T2D). ANGPTL8 associates with ANGPTL3 in the non-diabetic subjects while it associated more with ANGPTL4 (显示 ANGPTL4 抗体) in the obese and T2D subjects.
ANGPTL3 is specifically correlated with HDL (显示 HSD11B1 抗体)-c, apoA-I (显示 APOA1 抗体), SAA (显示 SAA1 抗体) and HDL (显示 HSD11B1 抗体) function in female non-diabetic participants. The decrease of ANGPTL3 level in female T2DM patients might contribute to its weak association to HDL (显示 HSD11B1 抗体) components and function.
The ANGPTL3 gene lies within DOCK7 (显示 DOCK7 抗体), although the variant is within non-coding regions outside of ANGPTL3, within DOCK7 (显示 DOCK7 抗体), suggesting complex long-range regulatory effects on gene expression in coronary artery disease.
ANGPTL3 levels were associated with fasting insulin (显示 INS 抗体) and the homeostasis model assessment of insulin (显示 INS 抗体) resistance in Korean children.
An ANGPTL3-4-8 model was proposed to explain the variations of lipoprotein lipase (LPL (显示 LPL 抗体)) activity during the fed-fast cycle. Feeding induces ANGPTL8, activating the ANGPTL8-ANGPTL3 pathway, which inhibits LPL (显示 LCP1 抗体) in cardiac and skeletal muscles to direct circulating triglycerides (TG) to white adipose tissue; the reverse is true during fasting, which suppresses ANGPTL8 but induces ANGPTL4 (显示 ANGPTL4 抗体), thereby directing TG to muscles.
Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion
ANGPTL8 has a functional LPL (显示 LPL 抗体) inhibitory motif, but only inhibits LPL (显示 LPL 抗体) and increases plasma TG levels in mice in the presence of ANGPTL3
The data suggests that ANGPTL3 is part of the machinery causing dyslipidemia majorily via LPL (显示 LPL 抗体) inhibition in mastitis mice.
Using in vitro ketosis model by glucose starvation, studied inhibition of ketosis by momilactone B. Found momilactone B could regulate the angiopoietin-like-3 (ANGPTL3)-lipoprotein lipase (LPL (显示 LPL 抗体))pathway, and suppressed the expression of HMGCS2 (显示 HMGCS2 抗体) through the increased expression of STAT5b (显示 STAT5B 抗体).
This model suggests a general mechanism by which TAG trafficking is coordinated by lipasin, Angptl3 and Angptl4 (显示 ANGPTL4 抗体) at different nutritional statuses.
The deletion of ANGPTL3 tremendously attenuates proteinuria and protects podocytes from injury in a mouse model of adriamycin-induced nephropathy.
ANGPTL3 has a role in regulating white adipose tissue energy homeostasis but not in liver
Data indicate that expression of Angptl3 in hematopoietic stem cell (HSC (显示 FUT1 抗体)) through lentiviral transduction promoted HSC (显示 FUT1 抗体) expansion.
Angptl3 could induce actin filament rearrangement, mainly in lamellipodia formation, and that this process was mediated by integrin alpha(V)beta-mediated FAK and PI3K phosphorylation and Rac1 activation.
Furin (显示 FURIN 抗体) has a role as the primary in vivo convertase of ANGPTL3 and endothelial lipase (显示 LIPG 抗体) in hepatocytes
First report of molecular cloning and characterization of ANGPTL3 in pigs, which will be helpful for a better understanding of the role of ANGPTLs in lipid metabolism.
This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2.
, WITHDRAWN: zgc:111943
, angiopoietin-related protein 3-like
, angiopoietin 5
, angiopoietin-related protein 3
, angiopoietin-like protein 3