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AMOTL2 belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. 再加上，我们可以发Angiomotin Like 2 抗体 (19) 和 Angiomotin Like 2 蛋白 (4)和数多这个蛋白质的别的产品。
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Amotl2a function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 (显示 YAP1 ELISA试剂盒) and the Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) effector Lef1 (显示 LEF1 ELISA试剂盒).
amotL2 associates to the VE-cadherin adhesion complex where it couples adherens junctions to contractile actin fibres.
We demonstrate that amotl2 knockdown in zebrafish wild-type embryos results in embryonic dorsalization, and this effect can be antagonized by co-knockdown of the dorsal inducer beta-catenin2.
Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells
Amotl2 interacts preferentially with and facilitates translocation of the phosphorylated c-Src (显示 SRC ELISA试剂盒), which may in turn regulate the membrane architecture. These data provide the first evidence that amotl2 is essential for cell movements in vertebrate embryos.
these results provide novel insights into a dual tumor suppressive function of AMOTL2 by targeting both YAP (显示 YAP1 ELISA试剂盒) and AKT (显示 AKT1 ELISA试剂盒) in liver size control and cancer prevention
study reports for the first time that USP9X (显示 USP9X ELISA试剂盒) is a deubiquitinase of Angiomotin-like 2 (AMOTL2) and that AMOTL2 mono-ubiquitination is required for YAP (显示 YAP1 ELISA试剂盒) inhibition
mTORC2 (显示 CRTC2 ELISA试剂盒)-mediated phosphorylation of AMOTL2 blocks its ability to inhibit YAP (显示 YAP1 ELISA试剂盒) signaling.
AmotL2 expression correlates with loss of tissue architecture in tumors from human breast and colon cancer patients.
Scaffold proteins angiomotin (Amot (显示 AMOT ELISA试剂盒)) and angiomotin (显示 AMOT ELISA试剂盒)-related AmotL1 (显示 AMOTL1 ELISA试剂盒) and AmotL2 were recently identified as negative regulators of YAP (显示 YAP1 ELISA试剂盒) and TAZ (显示 TAZ ELISA试剂盒) by preventing their nuclear translocation.
These results collectively suggest that the Hippo pathway negatively regulates the actin-binding activity of Amot (显示 AMOT ELISA试剂盒) family members through direct phosphorylation.
These results demonstrate a role for Amotl2 in synaptic maturation and support the involvement of podosomes in this process.
AMOTL2 interacts with TAZ (显示 TAZ ELISA试剂盒) and modulates transcriptional activity of TAZ (显示 TAZ ELISA试剂盒).
AMOTL2 is as a novel activator of LATS2.
AmotL2 disrupts apical-basal cell polarity and promotes tumor invasion.
Amot (显示 AMOT ELISA试剂盒), Amotl1 (显示 AMOTL1 ELISA试剂盒), and Amotl2 are differentially expressed in uterine cells during the peri (显示 POSTN ELISA试剂盒)-implantation period.
Data show that MUPP1 (显示 MPDZ ELISA试剂盒) interacts with angiomotin (Amot (显示 AMOT ELISA试剂盒)), JEAP (显示 AMOTL1 ELISA试剂盒)/Amot (显示 AMOT ELISA试剂盒)-like 1 and MASCOT/Amot (显示 AMOT ELISA试剂盒)-like 2, and that all the Amot (显示 AMOT ELISA试剂盒)/JEAP (显示 AMOTL1 ELISA试剂盒) family proteins also interacted with Patj (显示 INADL ELISA试剂盒), a close relative of MUPP1 (显示 MPDZ ELISA试剂盒).
Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motins protein family.
angiomotin like 1
, angiomotin-like protein 1
, angiomotin like 2
, angiomotin-like 2a
, angiomotin-like protein 1-like
, angiomotin-like protein 2-like
, Leman coiled-coil protein
, angiomotin-like protein 2