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AMOTL2 belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. 再加上，我们可以发Angiomotin Like 2 蛋白 (4) 和 Angiomotin Like 2 试剂盒 (2)和数多这个蛋白质的别的产品。
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Human Polyclonal AMOTL2 Primary Antibody for WB - ABIN652806
Bratt, Wilson, Troyanovsky, Aase, Kessler, Van Meir, Holmgren, Meir: Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains. in Gene 2002
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Amotl2a function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 (显示 YAP1 抗体) and the Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) effector Lef1 (显示 LEF1 抗体).
amotL2 associates to the VE-cadherin adhesion complex where it couples adherens junctions to contractile actin fibres.
We demonstrate that amotl2 knockdown in zebrafish wild-type embryos results in embryonic dorsalization, and this effect can be antagonized by co-knockdown of the dorsal inducer beta-catenin2.
Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells
Amotl2 interacts preferentially with and facilitates translocation of the phosphorylated c-Src (显示 SRC 抗体), which may in turn regulate the membrane architecture. These data provide the first evidence that amotl2 is essential for cell movements in vertebrate embryos.
these results provide novel insights into a dual tumor suppressive function of AMOTL2 by targeting both YAP (显示 YAP1 抗体) and AKT (显示 AKT1 抗体) in liver size control and cancer prevention
study reports for the first time that USP9X (显示 USP9X 抗体) is a deubiquitinase of Angiomotin-like 2 (AMOTL2) and that AMOTL2 mono-ubiquitination is required for YAP (显示 YAP1 抗体) inhibition
mTORC2 (显示 CRTC2 抗体)-mediated phosphorylation of AMOTL2 blocks its ability to inhibit YAP (显示 YAP1 抗体) signaling.
AmotL2 expression correlates with loss of tissue architecture in tumors from human breast and colon cancer patients.
Scaffold proteins angiomotin (Amot (显示 AMOT 抗体)) and angiomotin (显示 AMOT 抗体)-related AmotL1 (显示 AMOTL1 抗体) and AmotL2 were recently identified as negative regulators of YAP (显示 YAP1 抗体) and TAZ (显示 TAZ 抗体) by preventing their nuclear translocation.
These results collectively suggest that the Hippo pathway negatively regulates the actin-binding activity of Amot (显示 AMOT 抗体) family members through direct phosphorylation.
These results demonstrate a role for Amotl2 in synaptic maturation and support the involvement of podosomes in this process.
AMOTL2 interacts with TAZ (显示 TAZ 抗体) and modulates transcriptional activity of TAZ (显示 TAZ 抗体).
AMOTL2 is as a novel activator of LATS2 (显示 LATS2 抗体).
AmotL2 disrupts apical-basal cell polarity and promotes tumor invasion.
Amot (显示 AMOT 抗体), Amotl1 (显示 AMOTL1 抗体), and Amotl2 are differentially expressed in uterine cells during the peri (显示 POSTN 抗体)-implantation period.
Data show that MUPP1 (显示 MPDZ 抗体) interacts with angiomotin (Amot (显示 AMOT 抗体)), JEAP (显示 AMOTL1 抗体)/Amot (显示 AMOT 抗体)-like 1 and MASCOT/Amot (显示 AMOT 抗体)-like 2, and that all the Amot (显示 AMOT 抗体)/JEAP (显示 AMOTL1 抗体) family proteins also interacted with Patj (显示 INADL 抗体), a close relative of MUPP1 (显示 MPDZ 抗体).
Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motins protein family.
Leman coiled-coil protein
, angiomotin-like protein 2
, angiomotin like 2
, angiomotin-like 2a
, angiomotin-like protein 2-like