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Aup1 encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes.
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Human Polyclonal Ancient Ubiquitous Protein 1 Primary Antibody for IHC, IHC (p) - ABIN4280472
Hartman, Liu, Zehmer, Luby-Phelps, Jo, Anderson, DeBose-Boyd: Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets. in The Journal of biological chemistry 2010
AUP1 may be a crucial factor in hepatic apoB100 (显示 APOB 抗体) quality control, determining the rate at which apoB100 (显示 APOB 抗体) is degraded or lipidated to enable VLDL particle assembly and secretion.
Monoubiquitinated AUP1 on the lipid droplet surface specifically induces clustering.
A novel role for Aup1 in maintenance of intracellular cholesterol homeostasis via mediation of the endoplasmic reticulum associated degradation of HMG-CoA reductase (显示 HMGCR 抗体).
AUP1 targeting signals
Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control.
The presence of the AUP1-Ube2g2 (显示 UBE2G2 抗体) complex at LDs provides a direct molecular link between LDs and the cellular ubiquitination machinery.
binding of Aup1 plays a crucial role in the alpha(IIb)beta(3) inside-out signaling
This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.
ancient ubiquitous protein 1