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There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific).
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Bae, Yang, Manithody, Rezaie: Engineering a disulfide bond to stabilize the calcium-binding loop of activated protein C eliminates its anticoagulant but not its protective signaling properties. in The Journal of biological chemistry 2007
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Díaz, Yuen, Iizuka, Higashiyama, Courtneidge: Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia. in The Journal of cell biology 2013
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Holscher, Davis, Tappenden: Human milk oligosaccharides influence maturation of human intestinal Caco-2Bbe and HT-29 cell lines. in The Journal of nutrition 2014
Manithody, Yang, Rezaie: Identification of exosite residues of factor Xa involved in recognition of PAR-2 on endothelial cells. in Biochemistry 2012
Cacciatore, Leonard, Chasin: The isolation of CHO cells with a site conferring a high and reproducible transgene amplification rate. in Journal of biotechnology 2013
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized.
alkaline phosphatase, tissue-nonspecific isozyme
, tissue non-specific alkaline phosphatase
, tissue-nonspecific alkaline phosphatase
, alkaline phosphatase, liver/bone/kidney
, alkaline phosphatase, tissue-nonspecific isozyme-like
, bacterial alkaline phosphatase
, alkaline phosphatase
, alkaline phosphatase-like