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Metallocarboxypeptidase that mediates tubulin deglutamylation.
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Mouse (Murine) Polyclonal AGBL5 Primary Antibody for ELISA, WB - ABIN4278660
Rogowski, van Dijk, Magiera, Bosc, Deloulme, Bosson, Peris, Gold, Lacroix, Bosch Grau, Bec, Larroque, Desagher, Holzer, Andrieux, Moutin, Janke: A family of protein-deglutamylating enzymes associated with neurodegeneration. in Cell 2010
Human Polyclonal AGBL5 Primary Antibody for ICC, IF - ABIN4278659
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
Ccp5 is the principal tubulin (显示 TUBB 抗体) deglutamylase that maintains functional levels of cilia tubulin (显示 TUBB 抗体) glutamylation.
These data suggest that CCP1 (显示 AGTPBP1 抗体) and CCP5 play important roles in developmental processes, particularly the development and functioning of cilia.
Homology models indicated destabilization of AGBL5 due to the p.Arg281Cys change.
Our study expands the clinical and allelic spectrum of known Retinal dystrophies genes, and reveals AGBL5, CDH16, and DNAJC17 as novel disease candidates.
The identification of AGBL5 and TTLL5 (显示 TTLL5 抗体), a previously described RP-associated gene encoding the tubulin tyrosine ligase (显示 TTLL1 抗体)-like family, member 5 protein, highlights the importance of poly- and deglutamylation in retinal homeostasis.
Due to the characteristic Retinitis Pigmentosa phenotype in patients carrying the AGBL5 missense mutation we suggest this gene as a candidate for a new form of autosomal recessively inherited RP
CCP5 (显示 GZMD 抗体) functions as a dual-functional deglutamylase cleaving both alpha- and gamma-linked glutamate (显示 GRIN1 抗体) from tubulin (显示 TUBB 抗体).
Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post- translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains (By similarity).
ATP/GTP-binding protein-like 5
, cytosolic carboxypeptidase-like protein 5
, ATP/GTP binding protein-like 5
, cytosolic carboxypeptidase-like protein 5-like
, carboxypeptidase 5, cytosolic
, Cytosolic carboxypeptidase-like protein 5