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The protein encoded by ABCG4 is included in the superfamily of ATP-binding cassette (ABC) transporters. 再加上，我们可以发ABCG4 蛋白 (4) 和 和数多这个蛋白质的别的产品。
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Human Polyclonal ABCG4 Primary Antibody for IF (p), IHC (p) - ABIN733568
Matsumoto, Chiba, Fujihara, Kubo, Sakamoto, Ueno: Immunohistochemical analysis of transporters related to clearance of amyloid-? peptides through blood-cerebrospinal fluid barrier in human brain. in Histochemistry and cell biology 2015
Show all 2 Pubmed References
Dog (Canine) Polyclonal ABCG4 Primary Antibody for ELISA - ABIN451661
Oldfield, Lowry, Ruddick, Lightman: ABCG4: a novel human white family ABC-transporter expressed in the brain and eye. in Biochimica et biophysica acta 2002
Modulation of miR-185-5p expression by EBV-miR-BART6 contributes to developmental differences in ABCG4 gene expression in human megakaryocytes
ABCG1 and ABCG4 alter the distribution of gamma-secretase on the plasma membrane, leading to the decreased gamma-secretase activity and suppressed Abeta secretion
Both the full-length and the short isoforms of ABCG1 can dimerize with ABCG4, whereas the ABCG2 multidrug transporter is unable to form a heterodimer with ABCG4.
Study suggests that high ABCG4 expression is associated with poor prognosis in patients with non-small-cell lung cancer with advanced stages.
HUWE1 and NEDD4-1 are two E3 ligases that are fundamental enzymes in the post-translational regulation of ABCG1 and ABCG4 protein levels and cellular cholesterol export activity
These results suggest that ABCA1, ABCG1, and ABCG4 are localized to distinct membrane meso-domains and disturb the meso-domain structures by reorganizing lipids on the plasma membrane
This study demonstreated that Abcg4 acts in concert with Abcg2 to efflux Abeta from the brain across the blood-brain barrier.
Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4: maps to human chromosome 11, is expressed abundantly in brain, and has alternatively-spliced isoforms
ABCG4 is expressed specifically in the brain and the eye.
ABCG1 and ABCG4 act in concert with ABCA1 to maximize the removal of excess cholesterol from cells and to generate cholesterol-rich lipoprotein particles
ABCG4 is highly expressed in microglia on alzheimer disease brain.
Human ABC transporters ABCG2 (BCRP) and ABCG4
ABCG4 may be involved in macrophage lipid homeostasis.
transplantation of bone marrow deficient in ABCG4, a transporter of unknown function, into Ldlr(-/-) mice resulted in thrombocytosis, accelerated thrombosis and atherosclerosis
The loss of ABCG1 and/or ABCG4 from the CNS results in changes in metabolic pathways and in behavior.
ABCG1 and ABCG4 promote cholesterol efflux from cells to HDL
based on the results, we propose that ABCG1 and ABCG4 mediate the intracellular vesicular transport of cholesterol/sterols within both neurons and astrocytes to regulate cholesterol transport in the brain
a role for Abcg4 in sterastrocyol efflux in the brain, Abcg4 promotes efflux of cholesterol, desmosterol, and possibly other sterol biosynthetic intermediates to HDL.
The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined.
ATP-binding cassette sub-family G member 4
, ATP-binding cassette, subfamily G, member 4
, putative ABC transporter
, ATP-binding cassette, sub-family G (WHITE), member 4
, ATP-binding cassette, subfamily G, member 4-like
, ATP-binding cassette sub-family G member 4-like
, ATP-binding cassette, sub-family G (WHITE), member 4b