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The protein encoded by ABCG1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. 再加上，我们可以发ABCG1 试剂盒 (33) 和 ABCG1 蛋白 (9)和数多这个蛋白质的别的产品。
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Chinese Hamster Polyclonal ABCG1 Primary Antibody for ICC, IF - ABIN152900
Hu, Abe-Dohmae, Tsujita, Iwamoto, Ogikubo, Otsuka, Kumon, Yokoyama: Biogenesis of HDL by SAA is dependent on ABCA1 in the liver in vivo. in Journal of lipid research 2008
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Human Polyclonal ABCG1 Primary Antibody for IF (p), IHC (p) - ABIN673719
Jia, Song, Yang, Ma, Li, Lu, Cao, Zhang, Zhu, Wang, Leng, Cao, Du, Xu: Effects of Tanshinone IIA on the modulation of miR‑33a and the SREBP‑2/Pcsk9 signaling pathway in hyperlipidemic rats. in Molecular medicine reports 2016
Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI (显示 SCARB1 抗体) or ABCG1 but not ABCA1 (显示 ABCA1 抗体).
ABCG1 regulates pulmonary surfactant metabolism
Hepatic free cholesterol content was significantly increased in NASH (显示 SAMSN1 抗体) as compared to non-NASH (显示 SAMSN1 抗体) subjects, while ABCA1 (显示 ABCA1 抗体) and ABCG1 protein levels significantly decreased with NASH (显示 SAMSN1 抗体) and fibrosis progression. The relative expression of miR (显示 MLXIP 抗体)-33a and miR (显示 MLXIP 抗体)-144 correlated inversely with ABCA1 (显示 ABCA1 抗体) but not with ABCG1 protein levels. miR (显示 MLXIP 抗体)-33a/144 and their target gene ABCA1 (显示 ABCA1 抗体) may contribute to the pathogenesis of NASH (显示 SAMSN1 抗体) in morbidly obese subjects.
Understanding the relationship between cholesterol and inflammation in the lung, and the role that ABC (显示 ABCB6 抗体) transporters play in this may illuminate new pathways to target for the treatment of inflammatory lung diseases
Findings suggest that the ABCG1-mediated efflux of cholesterol, but not of 7-ketocholesterol, shows specificity for structural domains of apoA-I (显示 APOA1 抗体) bound to reconstituted HDL (显示 HSD11B1 抗体). Although the mid region alone of apoA-I (显示 APOA1 抗体) associated to rHDL can promote ABCG1-mediated cholesterol efflux, deletion of carboxyl-terminal region 185-243 from full-length apoA-I (显示 APOA1 抗体) diminishes ABCG1-mediated cholesterol efflux.
ABCG1 regulates T cell differentiation into Tregs, highlighting a pathway by which cholesterol accumulation can influence T cell homeostasis in atherosclerosis
Data show that ELOVL7 (显示 ELOVL7 抗体), SOCS3 (显示 SOCS3 抗体), ACSL4 (显示 ACSL4 抗体) and CLU (显示 CLU 抗体) were upregulated while PRKAR1A (显示 PRKAR1A 抗体) and ABCG1 were downregulated in the phlegm-dampness group.
ABCG1 and ABCG4 (显示 ABCG4 抗体) alter the distribution of gamma-secretase on the plasma membrane, leading to the decreased gamma-secretase activity and suppressed Abeta (显示 APP 抗体) secretion
Both the full-length and the short isoforms of ABCG1 can dimerize with ABCG4 (显示 ABCG4 抗体), whereas the ABCG2 (显示 ABCG2 抗体) multidrug transporter is unable to form a heterodimer with ABCG4 (显示 ABCG4 抗体).
DNA methylation (显示 HELLS 抗体) at the ABCG1 locus cg06500161 in blood DNA was associated with an increased risk for future type2 diabetes.
we have newly identified a haplotype-tagging SNP, rs225396, in ABCG1 to be associated with PCV and nAMD in Chinese and Japanese cohorts. This provides new evidence to support ABCG1 as a susceptibility gene for PCV and nAMD.
Our data indicate that a combination of vildagliptin and pravastatin significantly induces the expression of LXR (显示 NR1H3 抗体)-ABCA1 (显示 ABCA1 抗体)/ABCG1 cascade and improves cholesterol efflux (P > 0.05) in adipocytes. Our data may explain, at least in part, the improvement in HDL (显示 HSD11B1 抗体)-C levels observed in patients receiving both medications
ABCG1 may play a protective role in early-stage atherosclerosis by reducing endothelial activation induced by oscillatory shear stress via suppressing the inflammatory response.
Endothelial cholesterol efflux pathways mediated by ABCA1 (显示 ABCA1 抗体) and ABCG1 are nonredundant and atheroprotective, reflecting preservation of endothelial NO synthase (显示 NOS 抗体) activity and suppression of endothelial inflammation, especially in regions of disturbed arterial blood flow.
ABCG1, irrespective of either a leucine or proline at position 550, is an intracellular protein (显示 CKAP2 抗体) that localizes to vesicles of the endosomal pathway where it functions to mobilize sterols away from the endoplasmic reticulum and out of the cell.
our study suggests that MEK1 (显示 MAP2K1 抗体)/2 inhibitors activate macrophage ABCG1 expression/RCT (显示 FOXE3 抗体), and inhibit foam cell formation and lesion development by multiple mechanisms, supporting the concept that ERK1/2 (显示 MAPK1/3 抗体) inhibition is anti-atherogenic
miR-33 augments macrophage lipid rafts and enhances proinflammatory cytokine induction and NF-kappaB activation by LPS. This occurs through an ABCA1- and ABCG1-dependent mechanism and is reversible by interventions upon raft cholesterol and by ABC transporter-inducing liver X receptor agonists.
ABCG1 expression was down-regulated by TLR4 (显示 TLR4 抗体), which induces inflammation and lipid accumulation in vascular smooth muscle cells via PPARgamma (显示 PPARG 抗体)/LXRalpha (显示 NR1H3 抗体) signaling.
Visfatin (显示 NAMPT 抗体) upregulated CD36 (显示 CD36 抗体) and SRA (显示 MSR1 抗体) expression and downregulated ABCA1 (显示 ABCA1 抗体) and ABCG1 expression, subsequently increased ox-LDL uptake and decreased cholesterol efflux, and finally promoted foam cell formation via the PI3K- and ERK (显示 EPHB2 抗体)-dependent pathways.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified.
ATP-binding cassette sub-family G member 1
, ATP-binding cassette, sub-family G (WHITE), member 1
, ATP-binding cassette sub-family G member 1-like
, ABC transporter 8
, ATP-binding cassette transporter 8
, ATP-binding cassette transporter member 1 of subfamily G
, homolog of Drosophila white
, white protein homolog (ATP-binding cassette transporter 8)
, ATP-binding cassette 8
, ATP-binding cassette, subfamily G, member 1
, white protein homolog