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Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. 再加上，我们可以发APEX2 抗体 (59) 和 APEX2 蛋白 (3)和数多这个蛋白质的别的产品。
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Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2.
Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III
Ape2 exhibits strong 3'-5' exonuclease and 3'-phosphodiesterase activities and has only a very weak AP-endonuclease activity.
Ape2 may be involved in repair of oxidative DNA damage and PCNA-dependent repair synthesis.
Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
APE2 associates with Chk1; a serine residue (S86) in the Chk1-binding motif of APE2 is essential for Chk1 phosphorylation, indicating a Claspin-like but distinct role for APE2 in ATR-Chk1 signaling.
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
AP endonuclease 2
, AP endonuclease XTH2
, DNA-(apurinic or apyrimidinic site) lyase 2
, apurinic/apyrimidinic endonuclease-like 2
, APEX nuclease 2
, apurinic-apyrimidinic endonuclease 2
, APEX nuclease (apurinic/apyrimidinic endonuclease) 2
, DNA-(apurinic or apyrimidinic site) lyase 2-like