APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) ELISA试剂盒

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases.

list all ELISA KIts 基因 基因ID UniProt
 APEX2 APEX2 27301 Q9UBZ4
小鼠 APEX2 APEX2 77622 Q68G58
大鼠 APEX2 APEX2 317628  
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< 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests Log in to see 11至18个工作日
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适于 APEX2 相互作用对的更多 ELISA 试剂盒

Human APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. Determinants in nuclease specificity of Ape1 (显示 APEX1 ELISA试剂盒) and Ape2, human homologues of Escherichia coli exonuclease (显示 EXO1 ELISA试剂盒) III

  2. Ape2 exhibits strong 3'-5' exonuclease and 3'-phosphodiesterase activities and has only a very weak AP-endonuclease activity.

  3. Ape2 may be involved in repair of oxidative DNA damage and PCNA (显示 PCNA ELISA试剂盒)-dependent repair synthesis.

Xenopus laevis APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. APE2 associates with Chk1 (显示 CHEK1 ELISA试剂盒); a serine residue (S86) in the Chk1 (显示 CHEK1 ELISA试剂盒)-binding motif of APE2 is essential for Chk1 (显示 CHEK1 ELISA试剂盒) phosphorylation, indicating a Claspin (显示 CLSPN ELISA试剂盒)-like but distinct role for APE2 in ATR-Chk1 (显示 CHEK1 ELISA试剂盒) signaling.

Mouse (Murine) APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. expression of Apex 2 in chondrocytes appears to be associated with the degeneration of articular cartilage in osteoarthritis.

  2. Results indicate a role for apurinic/apyrimidinic endonuclease (APE) 2 (Apex2) in the protection of germinal center (GC) cells from activation-induced cytidine deaminase (显示 AICDA ELISA试剂盒) (AID)-independent damage.

  3. data provide new insight into error-prone repair of AID-induced lesions, which we propose is facilitated by down-regulation of APE1 (显示 APEX1 ELISA试剂盒) and up-regulation of APE2 expression in germinal center B cells.

  4. Extensive analysis of bone marrow hematopoiesis in APE2-deficient mice finds inhibition of the pro-B to pre-B lymphocyte (显示 AKAP17A ELISA试剂盒) transition, due to a p53 (显示 TP53 ELISA试剂盒)-dependent DNA damage response, independent from its ubiquitous and essential homolog APE1 (显示 APEX1 ELISA试剂盒).

  5. APEX2 is required for proper cell cycle progression of proliferating lymphocytes.

  6. Both APE1 (显示 APEX1 ELISA试剂盒) and APE2 function in antibody switch recomibination, resulting in double stranded breaks necesary for this recombination.

  7. The present study clearly demonstrates that APEX2-null lymphocytes have a higher frequency of DNA breaks, indicating that APEX2 may play an important role(s) during their generation and/or repair.

  8. Apex2 is required for efficient somatic hypermutation of immunoglobulin genes.

APEX2 抗原简介

Antigen Summary

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with APEX2

  • apurinic/apyrimidinic endodeoxyribonuclease 2 (APEX2) 抗体
  • apurinic/apyrimidinic endodeoxyribonuclease 2 (apex2) 抗体
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (apex2) 抗体
  • apurinic/apyrimidinic endodeoxyribonuclease 2 L homeolog (apex2.L) 抗体
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (APEX2) 抗体
  • apurinic/apyrimidinic endonuclease 2 (Apex2) 抗体
  • apurinic/apyrimidinic endodeoxyribonuclease 2 (Apex2) 抗体
  • ape2 抗体
  • apexl2 抗体
  • C430040P13Rik 抗体
  • xth2 抗体
  • zgc:55889 抗体

Protein level used designations for APEX2

AP endonuclease 2 , AP endonuclease XTH2 , DNA-(apurinic or apyrimidinic site) lyase 2 , apurinic/apyrimidinic endonuclease-like 2 , APEX nuclease 2 , apurinic-apyrimidinic endonuclease 2 , APEX nuclease (apurinic/apyrimidinic endonuclease) 2 , DNA-(apurinic or apyrimidinic site) lyase 2-like

GENE ID SPECIES
27301 Homo sapiens
448512 Xenopus (Silurana) tropicalis
393115 Danio rerio
446614 Xenopus laevis
491499 Canis lupus familiaris
511790 Bos taurus
702084 Macaca mulatta
100410557 Callithrix jacchus
100434759 Pongo abelii
77622 Mus musculus
317628 Rattus norvegicus
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