ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) ELISA试剂盒

ADAMTS5 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. 再加上,我们可以发ADAMTS5 抗体 (119)ADAMTS5 蛋白 (9)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
ADAMTS5 23794 Q9R001
ADAMTS5 11096 Q9UNA0
ADAMTS5 304135  
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0.112 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests Log in to see 13至16个工作日
$736.84
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大鼠 0.118 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests Log in to see 13至16个工作日
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小鼠 0.156 ng/mL 0.625-40 ng/mL Typical standard curve 96 Tests Log in to see 15至18个工作日
$910.56
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Cow 0.156 ng/mL 0.625-40 ng/mL Typical standard curve 96 Tests Log in to see 15至18个工作日
$1,026.67
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0.1 ng/mL 0.5-10 ng/mL   96 Tests Log in to see 15至18个工作日
$707.14
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0.1 ng/mL 0.5-10 ng/mL   96 Tests Log in to see 15至18个工作日
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豚鼠 0.1 ng/mL 0.5-10 ng/mL   96 Tests Log in to see 15至18个工作日
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0.1 ng/mL 0.5-10 ng/mL   96 Tests Log in to see 15至18个工作日
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引用最多的ADAMTS5 ELISA试剂盒

  1. Human ADAMTS5 ELISA Kit for Sandwich ELISA - ABIN649163 : Mern, Fontana, Beierfuß, Thomé, Hegewald et al.: A combinatorial relative mass value evaluation of endogenous bioactive proteins in three-dimensional cultured nucleus pulposus cells of herniated intervertebral discs: identification of potential ... in PLoS ONE 2013 (PubMed)
    Show all 7 Pubmed References

  2. Human ADAMTS5 ELISA Kit for Sandwich ELISA - ABIN827174 : Huang, Song, Li, Xiao, Chen, Gong, Zeng, Yang, Chen: Pellet coculture of osteoarthritic chondrocytes and infrapatellar fat pad-derived mesenchymal stem cells with chitosan/hyaluronic acid nanoparticles promotes chondrogenic differentiation. in Stem cell research & therapy 2018 (PubMed)
    Show all 2 Pubmed References

适于 ADAMTS5 相互作用对的更多 ELISA 试剂盒

Mouse (Murine) ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) interaction partners

  1. Energy expenditure and thermogenesis were not significantly different between KO and WT ADAMTS5-J mice (in contrast to somewhat enhanced levels in ADAMTS5-P mice). Insulin (显示 INS ELISA试剂盒) sensitivity was improved in the ADAMTS5-J KO mice, and they were protected against non-alcoholic steatohepatitis in the DIO model

  2. Adamts5(-/-) mice were protected from hepatic mitochondrial dysfunction, as indicated by increased mitochondrial respiratory chain complex activity, higher ATP levels and higher expression of antioxidant enzymes. Absence of ADAMTS5 preserves liver integrity in a diet-induced obesity model.

  3. research emphasises the importance of ADAMTS5 expression in the control of influenza virus infection and highlights the potential for development of ADAMTS5-based therapeutic strategies to reduce morbidity and mortality

  4. TS5 protein functions to suppress glucose uptake in adipose-derived stromal cells and thereby inhibits the synthesis, and promotes the intracellular degradation of Acan (显示 ACAN ELISA试剂盒) and Vcan (显示 Vcan ELISA试剂盒) by an ADAMTS (显示 ADAMTS1 ELISA试剂盒) other than TS5.

  5. Data suggest that ADAMTS-5 oligomerization is required for full aggrecanase (显示 ADAMTS4 ELISA试剂盒) activity in vitro and in situ (as seen in knee joint of mouse model of inflammatory arthritis); thus, blocking oligomerization inhibits ADAMTS-5 activity.

  6. aggrecan (显示 ACAN ELISA试剂盒) and brevican (显示 BCAN ELISA试剂盒) proteolysis is compensated in Adamts4 (显示 ADAMTS4 ELISA试剂盒)-/- or Adamts5-/- mice by ADAMTS (显示 ADAMTS1 ELISA试剂盒) proteoglycanase (显示 MMP3 ELISA试剂盒) family members but a threshold of versican (显示 Vcan ELISA试剂盒) proteolysis is sensitive to the loss of a single ADAMTS (显示 ADAMTS1 ELISA试剂盒) proteoglycanase (显示 MMP3 ELISA试剂盒) during spinal cord injury

  7. The present study reveals ADAMT-5 expression by mast cells(MCs (显示 SMCP ELISA试剂盒)) and that MC activation regulates the expression of the protease, thus implicating the ADAMT-5 of protease in MC function.

  8. Western blot analyses indicated that aggrecanase (显示 ADAMTS4 ELISA试剂盒)-generated proteoglycan (显示 Vcan ELISA试剂盒) fragments are produced after SCI.

  9. RelA/p65 (显示 NFkBP65 ELISA试剂盒) is a potent transcriptional activator of ADAMTS5 in chondrocytes during osteoarthritis development.

  10. Repair of biomechanically compromised tendons exhibiting midsubstance chondroid accumulation requires ADAMTS5.

Human ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) interaction partners

  1. Data suggest that 3prime untranslated region of ADAMTS5 mRNA contains 'seedmatched-sequence' for hsa (显示 CD24 ELISA试剂盒)-miR (显示 MLXIP ELISA试剂盒)-140-3p (microRNA-140-3p); in chondrocytes from articular cartilage of patients with knee osteoarthritis, interleukin-1beta up-regulates expression of ADAMTS5 and down-regulates expression of hsa (显示 CD24 ELISA试剂盒)-miR (显示 MLXIP ELISA试剂盒)-140-3p. (ADAMTS5 = ADAM metallopeptidase with thrombospondin type 1 motif 5 A)

  2. A novel genetic variant in ADAMTS5 is associated with bicuspid aortic valve disease.

  3. expression by synovial cells induced by hemoglobin at low doses, suggesting a possible role for hemoglobin in cartilage damage after intra-articular hemorrhage

  4. The SNPs rs1337185 in COL11A1 (显示 COL11A1 ELISA试剂盒) and rs162509 in ADAMTS5 are associated with susceptibility to lumbar disc degeneration. The C allele of rs1337185 is risky for patients who are affected by lumbar pathologies such as disc herniation, stenosis and spondylolisthesis. The G allele of rs16250 represents a risk factor for the development of disc herniation.

  5. ADAMTS5 is hypermethylated and inhibits cancer cells invasion and migration in colorectal cancer, and correlates with OS and DFS (显示 FST ELISA试剂盒).

  6. Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1 (显示 LRP1 ELISA试剂盒).

  7. MMP-13 (显示 MMP13 ELISA试剂盒) may play a role on physiological turnover of cartilage extracellular matrix and that LRP1 (显示 LRP1 ELISA试剂盒) is a key modulator of extracellular levels of MMP-13 (显示 MMP13 ELISA试剂盒) and its internalization is independent of the levels of ADAMTS-4 (显示 ADAMTS4 ELISA试剂盒), -5 and TIMP-3 (显示 TIMP3 ELISA试剂盒).

  8. The IL1B (显示 IL1B ELISA试剂盒)/AP-1 (显示 FOSB ELISA试剂盒)/miR (显示 MLXIP ELISA试剂盒)-30a/ADAMTS-5 axis regulates cartilage matrix degradation in osteoarthritis.

  9. The findings suggest that miR (显示 MLXIP ELISA试剂盒)-140 suppresses colorectal cancer progression and metastasis, possibly through downregulating ADAMTS5 and IGFBP5 (显示 IGFBP5 ELISA试剂盒).

  10. Results provide direct evidence indicating that Fibulin-2 (显示 FBLN2 ELISA试剂盒) is a novel substrate of ADAMTS-5 and that this proteolysis could alter the cellular microenvironment affecting the balance between protumor and antitumor effects associated to both Fibulin-2 (显示 FBLN2 ELISA试剂盒) and the ADAMTSs metalloproteases.

Cow (Bovine) ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) interaction partners

  1. The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (aggrecanase (显示 ADAMTS4 ELISA试剂盒)) explains the minor contribution of the MMP enzymes to aggrecan (显示 ACAN ELISA试剂盒) catabolism in vivo.

  2. ADAMTS4 (显示 ADAMTS4 ELISA试剂盒) and ADAMTS5 are inhibited by alpha2-macroglobulin (显示 A2M ELISA试剂盒)

  3. identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 (显示 ADAMTS4 ELISA试剂盒) and ADAMTS-5

  4. Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production.

ADAMTS5 抗原简介

Antigen Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.

Gene names and symbols associated with ADAMTS5

  • ADAM metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS5) 抗体
  • ADAM metallopeptidase with thrombospondin type 1 motif 5 (adamts5) 抗体
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) (Adamts5) 抗体
  • ADAM metallopeptidase with thrombospondin type 1 motif, 5 (Adamts5) 抗体
  • 9530092O11Rik 抗体
  • ADAM-TS5 抗体
  • ADAM-TS 5 抗体
  • ADAM-TS 11 抗体
  • ADAMTS-5 抗体
  • ADAMTS-11 抗体
  • ADAMTS1 抗体
  • ADAMTS11 抗体
  • ADMP-2 抗体
  • AI481094 抗体
  • ASMP-2 抗体

Protein level used designations for ADAMTS5

ADAM metallopeptidase with thrombospondin type 1 motif, 5 , a disintegrin and metalloproteinase with thrombospondin motifs 5-like , A disintegrin and metalloproteinase with thrombospondin motifs 5 , ADAM-TS 5 , ADAMTS-5 , ADMP-2 , aggrecanase-2 , implantin , a disintegrin and metalloproteinase with thrombospondin motifs 11 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) , ADAM-TS5 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)

GENE ID SPECIES
100091913 Ornithorhynchus anatinus
100441162 Pongo abelii
100488158 Xenopus (Silurana) tropicalis
100552915 Anolis carolinensis
23794 Mus musculus
11096 Homo sapiens
100522952 Sus scrofa
286805 Bos taurus
304135 Rattus norvegicus
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